The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

Autor: Raul Araya-Secchi, Katrine Bugge, Pernille Seiffert, Amalie Petry, Gitte W Haxholm, Kresten Lindorff-Larsen, Stine Falsig Pedersen, Lise Arleth, Birthe B Kragelund

Publikováno v: eLife, Vol 12 (2023)

Class 1 cytokine receptors transmit signals through the membrane by a single transmembrane helix to an intrinsically disordered cytoplasmic domain that lacks kinase activity. While specific binding to phosphoinositides has been reported for the prola

Externí odkaz: https://doaj.org/article/dfbd0e7ab7e54119a7d5a8fe4a1c6660

Collective mechanical responses of cadherin-based adhesive junctions as predicted by simulations

Autor: Marcos Sotomayor, Raul Araya-Secchi, Sanket Walujkar, Brandon L. Neel, Collin R. Nisler

Publikováno v: Biophys J

Cadherin-based adherens junctions and desmosomes help stabilize cell-cell contacts with additional function in mechano-signaling, while clustered protocadherin junctions are responsible for directing neuronal circuits assembly. Structural models for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886307af2b31bb3b73bbf5f5d6bdc02b
https://doi.org/10.1016/j.bpj.2022.02.008

Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception

Autor: Yoshie Narui, Marcos Sotomayor, Elakkiya Tamilselvan, Pedro De-la-Torre, Carissa F. Klanseck, Conghui Chen, Deepanshu Choudhary, Raul Araya-Secchi, Lahiru N. Wimalasena, Brandon L. Neel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Choudhary, D, Narui, Y, Neel, B L, Wimalasena, L N, Klanseck, C F, De-la-Torre, P, Chen, C, Araya-Secchi, R, Tamilselvan, E & Sotomayor, M 2020, ' Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 40, pp. 24837-24848 . https://doi.org/10.1073/pnas.1920444117

Significance When sound vibrations reach the inner ear, fine protein filaments called “tip links” stretch and open cochlear hair-cell mechanosensitive channels that trigger sensory perception. Similarly, vestibular hair cells use tip links to sen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81055b18958d3660db49ac60fc5f6f0b
https://doi.org/10.1073/pnas.1920444117

Rio de Janeiro global consensus on landmarks, definitions and classifications in barrett’s esophagus: world endoscopy organization Delphi study

Autor: Fabian Emura, Viveksandeep Thoguluva Chandrasekar, Cesare Hassan, David Armstrong, Helmut Messmann, Vitor Arantes, Raul Araya, Oscar Barrera-Leon, Jacques J.G. H.M. Bergman, Pradeep Bandhari, Michael J. Bourke, Cecilio Cerisoli, Philip Wai-Yan Chiu, Madhav Desai, Mário Dinis-Ribeiro, Gary W. Falk, Mitsuhiro Fujishiro, Srinivas Gaddam, Kenichi Goda, Seth Gross, Rehan Haidry, Lawrence Ho, Prasad G. Iyer, Sergey Kashin, Shivangi Kothari, Yeong Yeh Lee, Koji Matsuda, Horst Neuhaus, Tsuneo Oyama, Krish Ragunath, Alessandro Repici, Nicholas Shaheen, Rajvinder Singh, Sergio Sobrino-Cossio, Kenneth K. Wang, Irving Waxman, Prateek Sharma

Publikováno v: Gastroenterology, 163(1), 84-96.e2. W.B. Saunders Ltd

Background & Aims: Despite the significant advances made in the diagnosis and treatment of Barrett's esophagus (BE), there is still a need for standardized definitions, appropriate recognition of endoscopic landmarks, and consistent use of classifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7312cfb7237da33bf8b3cc59a7a358
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/94602

Order and disorder - An integrative structure of the full-length human growth hormone receptor

Autor: Helena Steinocher, Raul Araya-Secchi, Maikel C. Rheinstädter, Yong Wang, Noah Kassem, Martin Cramer Pedersen, Anne S. Ulrich, Katrine Bugge, Jochen Bürck, Abigail Barclay, Birthe B. Kragelund, Aneta J. Lenard, Michael Landreh, Cagla Sahin, Lise Arleth, Kresten Lindorff-Larsen, Per Amstrup Pedersen, Adree Khondker

Publikováno v: 'Science Advances ', vol: 7, pages: eabh3805-1-eabh3805-20 (2021)
Science Advances, 7 (27), Art.-Nr.: eabh3805
Kassem, N, Araya-Secchi, R, Bugge, K, Barclay, A, Steinocher, H, Khondker, A, Wang, Y, Lenard, A J, Bürck, J, Sahin, C, Ulrich, A S, Landreh, M, Pedersen, M C, Rheinstädter, M C, Pedersen, P A, Lindorff-Larsen, K, Arleth, L & Kragelund, B B 2021, ' Order and disorder-An integrative structure of the full-length human growth hormone receptor ', Science Advances, vol. 7, no. 27, eabh3805 . https://doi.org/10.1126/sciadv.abh3805
Science advances 7(27), eabh3805 (1-19) (2021). doi:10.1126/sciadv.abh3805
'Science Advances ', vol: 7, pages: eabh3805-1-eabh3805-19 (2021)
Science Advances

Science advances 7(27), eabh3805 (1-19) (2021). doi:10.1126/sciadv.abh3805
Because of its small size (70 kilodalton) and large content of structural disorder (>50%), the human growth hormone receptor (hGHR) falls between the cracks of convention

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657169a20ecc942385443443830c63df