Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Raul Alba"'
Autor:
Prakrati C. Acharya, Raul Alba, Pajaree Krisanapan, Chirag M. Acharya, Supawadee Suppadungsuk, Eva Csongradi, Michael A. Mao, Iasmina M. Craici, Jing Miao, Charat Thongprayoon, Wisit Cheungpasitporn
Publikováno v:
Diseases, Vol 12, Iss 8, p 185 (2024)
Chronic kidney disease (CKD) patients can benefit from personalized education on lifestyle and nutrition management strategies to enhance healthcare outcomes. The potential use of chatbots, introduced in 2022, as a tool for educating CKD patients has
Externí odkaz:
https://doaj.org/article/de28e5e8318b4a4a99ec1b95755ba598
Autor:
Andrew H. Baker, Alan L. Parker, Angela C. Bradshaw, Stuart A. Nicklin, Iain A. McNeish, Raul Alba, Lynda Coughlan
Publikováno v:
Viruses, Vol 2, Iss 10, Pp 2290-2355 (2010)
Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing goal in the field of clinical gene therapy. To achieve this, platform vectors must combine efficient retargeting strategies with detargeting modifications to
Externí odkaz:
https://doaj.org/article/259cc6d4ac4c4da5a391f457b3764772
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19564 (2011)
We have previously described a new family of mutant adenoviruses carrying different combinations of attB/attP sequences from bacteriophage PhiC31 flanking the Ad5 packaging domain. These novel helper viruses have a significantly delayed viral life cy
Externí odkaz:
https://doaj.org/article/face692722f548ef84b28f4191e0ef99
Autor:
Raul Alba
Publikováno v:
SMPTE 2020 Annual Technical Conference and Exhibition.
The world has changed. Technologies have evolved. People don't consume news content as they used to.-The way many media companies are organized is not suitable for the needs that today's fast-paced news consumption habits impose. Media organizations
Autor:
Ashley M. Miller, Raul Alba, Angela C. Bradshaw, Laura Denby, Alan L. Parker, Nico van Rooijen, Lynda Coughlan, Jenny A. Greig, Simon N. Waddington, Stuart A. Nicklin, Hongjie Wang, Robert A. McDonald, André Lieber, John H. McVey, Andrew H. Baker, Suzanne M. K. Buckley
Publikováno v:
Alba, R, Bradshaw, A C, Coughlan, L, Denby, L, McDonald, R A, Waddington, S N, Buckley, S M K, Greig, J A, Parker, A L, Miller, A M, Wang, H J, Lieber, A, van Rooijen, N, Mcvey, J H, Nicklin, S A & Baker, A H 2010, ' Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors ', Blood, vol. 116, no. 15, pp. 2656-2664 . https://doi.org/10.1182/blood-2009-12-260026
Blood, 116(15), 2656-2664. American Society of Hematology
Blood, 116(15), 2656-2664. American Society of Hematology
A major limitation for adenoviral transduction in vivo is the profound liver tropism of adenovirus type 5 (Ad5). Recently, we demonstrated that coagulation factor X (FX) binds to Ad5-hexon protein at high affinity to mediate hepatocyte transduction a
Autor:
Nico van Rooijen, Ashley M. Miller, Stuart A. Nicklin, Angela C. Bradshaw, Andy Baker, Robert A. McDonald, Raul Alba, Lynda Coughlan, Alan L. Parker
Publikováno v:
Human Gene Therapy. 21:496-506
Autor:
Dan H. Barouch, Nico van Rooijen, Alan L. Parker, Jaap Goudsmit, Stuart A. Nicklin, David Bhella, Simon N. Waddington, Andrew H. Baker, Raul Alba, Jerome Custers, Angela C. Bradshaw, John H. McVey
Publikováno v:
Blood, 114(5), 965-971. American Society of Hematology
Alba, R, Bradshaw, A C, Parker, A L, Bhella, D, Waddington, S N, Nicklin, S A, van Rooijen, N, Custers, J, Goudsmit, J, Barouch, D H, Mcvey, J H & Baker, A H 2009, ' Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer ', Blood, vol. 114, no. 5, pp. 965-971 . https://doi.org/10.1182/blood-2009-03-208835
Alba, R, Bradshaw, A C, Parker, A L, Bhella, D, Waddington, S N, Nicklin, S A, van Rooijen, N, Custers, J, Goudsmit, J, Barouch, D H, Mcvey, J H & Baker, A H 2009, ' Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer ', Blood, vol. 114, no. 5, pp. 965-971 . https://doi.org/10.1182/blood-2009-03-208835
Recent studies have demonstrated the importance of coagulation factor X (FX) in adenovirus (Ad) serotype 5–mediated liver transduction in vivo. FX binds to the adenovirus hexon hypervariable regions (HVRs). Here, we perform a systematic analysis of
Publikováno v:
Virology. 367:51-58
Current strategies to amplify helper-dependent adenovirus, based on excision of the packaging signal, do not routinely reduce helper adenovirus contamination below 1%. Here, we have tested if reducing the efficiency of the packaging process of the he
Publikováno v:
Gene Therapy. 12:S18-S27
Last-generation adenovirus vectors, also called helper-dependent or gutless adenovirus, are very attractive for gene therapy because the associated in vivo immune response is highly reduced compared to first- and second-generation adenovirus vectors,
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1089
Adenoviral vectors hold immense potential for a wide variety of gene therapy based applications; however, their efficacy and toxicity is dictated by "off target" interactions that preclude cell specific targeting to sites of disease. A number of "off