Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Raul A. Urrutia"'
KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress
Autor:
Yizeng Yang, Dharmendra Bhargava, Xiao Chen, Taicheng Zhou, Gizem Dursuk, Wenpeng Jiang, Jinshen Wang, Zhen Zong, Sharyn I. Katz, Gwen A. Lomberk, Raul A. Urrutia, Jonathan P. Katz
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-10 (2023)
Abstract In response to stress, cells make a critical decision to arrest or undergo apoptosis, mediated in large part by the tumor suppressor p53. Yet the mechanisms of these cell fate decisions remain largely unknown, particularly in normal cells. H
Externí odkaz:
https://doaj.org/article/ec7f0cfa3b1b4e0b99fa62ec85368f3d
Autor:
Samuel F. Carlson, Mohammed A. Kamalia, Michael T. Zimermann, Raul A. Urrutia, David L. Joyce
Publikováno v:
Heart Vessels and Transplantation, Vol 6, Iss 4, Pp 195-202 (2022)
Heart failure (HF) is a leading cause of morbidity and mortality in the United States. While medical management and mechanical circulatory support have undergone significant advancement in recent years, orthotopic heart transplantation (OHT) remains
Externí odkaz:
https://doaj.org/article/a4d944b50ccc4ef59b7ae0d8edc3101b
Publikováno v:
Pharmacy, Vol 11, Iss 6, p 178 (2023)
(1) Background: This retrospective analysis utilizing electronic medical record (EMR) data from a tertiary integrated health system sought to identify patients and prescribers who would benefit from pharmacogenomic (PGx) testing based on Clinical Pha
Externí odkaz:
https://doaj.org/article/79f47edbc5634bdb99119bf3247f26a2
Autor:
Adebowale O. Bamidele, Phyllis A. Svingen, Mary R. Sagstetter, Olga F. Sarmento, Michelle Gonzalez, Manuel B. Braga Neto, Subra Kugathasan, Gwen Lomberk, Raul A. Urrutia, William A. Faubion, Jr.
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 55-71 (2019)
Background & Aims: Forkhead box protein 3 (FOXP3)+ regulatory T cell (Treg) dysfunction is associated with autoimmune diseases; however, the mechanisms responsible for inflammatory bowel disease pathophysiology are poorly understood. Here, we tested
Externí odkaz:
https://doaj.org/article/5df0aaa0945a4199bd6ad8779e971419
Motor Neuron Generation from iPSCs from Identical Twins Discordant for Amyotrophic Lateral Sclerosis
Autor:
Emily R. Seminary, Stephanie Santarriaga, Lynn Wheeler, Marie Mejaki, Jenica Abrudan, Wendy Demos, Michael T. Zimmermann, Raul A. Urrutia, Dominic Fee, Paul E. Barkhaus, Allison D. Ebert
Publikováno v:
Cells, Vol 9, Iss 3, p 571 (2020)
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder characterized by the loss of the upper and lower motor neurons. Approximately 10% of cases are caused by specific mutations in known genes, with the remaining cases having no
Externí odkaz:
https://doaj.org/article/093317604a7548b89da66bc393e6a3f4
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
A significant number of studies support the idea that inflammatory responses are intimately associated with drug-, noise- and age-related hearing loss (DRHL, NRHL and ARHL). Consequently, several clinical strategies aimed at reducing auditory dysfunc
Externí odkaz:
https://doaj.org/article/739d4f13b5e94c3c98756de076297d0f
Autor:
Michael T. Zimmermann, Raul A. Urrutia, Patrick R. Blackburn, Margot A. Cousin, Nicole J. Boczek, Eric W. Klee, Colleen Macmurdo, Paldeep S. Atwal
Publikováno v:
Case Reports in Genetics, Vol 2017 (2017)
Loeys-Dietz syndrome (LDS) is a connective tissue disorder characterized by vascular findings of aneurysm and/or dissection of cerebral, thoracic, or abdominal arteries and skeletal findings. We report a case of a novel pathogenic variant in TGFBR2 a
Externí odkaz:
https://doaj.org/article/cb1a95c6c1b749a89383dc7dfaf49d3c
Publikováno v:
F1000Research, Vol 5 (2016)
Clinical genomics is now a reality and lies at the heart of individualized medicine efforts. The success of these approaches is evidenced by the increasing volume of publications that report causal links between genomic variants and disease. In spite
Externí odkaz:
https://doaj.org/article/7de43a21305e4c01af6b888e487ff577
Publikováno v:
F1000Research, Vol 5 (2016)
Clinical genomics is now a reality and lies at the heart of individualized medicine efforts. The success of these approaches is evidenced by the increasing volume of publications that report causal links between genomic variants and disease. In spite
Externí odkaz:
https://doaj.org/article/de26dad4b72742e5814cdaadd6461a4c
Autor:
Olga F. Sarmento, Phyllis A. Svingen, Yuning Xiong, Ramnik J. Xavier, Dermot McGovern, Thomas C. Smyrk, Konstantinos A. Papadakis, Raul A. Urrutia, William A. Faubion
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 2, Pp 188-202.e4 (2015)
Background & Aims: Kruppel-like Factor 14 (KLF14) proteins function as epigenetic reprogramming factors during cell differentiation in many cell populations and in engineered induced pluripotent stem cells. In this study, we determined the function o
Externí odkaz:
https://doaj.org/article/869989bc277d4c3392ac867bb72d6e25