Výsledky vyhledávání - "Raul A Maqueda-Alfaro"

Akademický článek

Enhanced BCR signaling inflicts early plasmablast and germinal center B cell death

Autor: Juan Carlos Yam-Puc, Lingling Zhang, Raul A Maqueda-Alfaro, Laura Garcia-Ibanez, Yang Zhang, Jessica Davies, Yotis A Senis, Michael Snaith, Kai-Michael Toellner

Publikováno v: iScience, Vol 24, Iss 2, Pp 102038- (2021)

Summary: It is still not clear how B cell receptor (BCR) signaling intensity affects plasma cell (PC) and germinal center (GC) B cell differentiation. We generated Cγ1Cre/wtPtpn6fl/fl mice where SHP-1, a negative regulator of BCR signaling, is delet

Externí odkaz: https://doaj.org/article/2683f28e2d1c4ba08fa4c42ead60d9c9

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Akademický článek

Elevated levels of enteric IgA in an unimmunised mouse model of Hyper IgM syndrome derived from gut-associated secondary lymph organs even in the absence of germinal centres

Autor: Felipe Hernandez-Cazares, Raul Antonio Maqueda-Alfaro, Catalina Lopez-Saucedo, Jesus Martinez-Barnetche, Juan Carlos Yam-Puc, Sergio Estrada-Parra, Leopoldo Flores-Romo, Teresa Estrada-Garcia

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

IntroductionPatients with Human Hyper IgM syndromes (HIGM) developed pulmonary and gastrointestinal infections since infancy and most patients have mutations in the CD40 ligand (CD40L) gene. Most HIGM patients compared to healthy subjects have higher

Externí odkaz: https://doaj.org/article/90b50441c0d14e6f90602e0da61bc5b8

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