Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Raul A Dulce"'
Autor:
Fakiha Firdaus, Manish Kuchakulla, Rehana Qureshi, Raul Ariel Dulce, Yash Soni, Derek J. Van Booven, Khushi Shah, Thomas Masterson, Omar Joel Rosete, Sanoj Punnen, Joshua M. Hare, Ranjith Ramasamy, Himanshu Arora
Publikováno v:
Cell Death and Disease, Vol 13, Iss 10, Pp 1-13 (2022)
Abstract Sustained oxidative stress in castration-resistant prostate cancer (CRPC) cells potentiates the overall tumor microenvironment (TME). Targeting the TME using colony-stimulating factor 1 receptor (CSF1R) inhibition is a promising therapy for
Externí odkaz:
https://doaj.org/article/e2dd2463f7454636b871a42fa1edf315
S‐Nitrosoglutathione Reductase Deficiency Causes Aberrant Placental S‐Nitrosylation and Preeclampsia
Autor:
Shathiyah Kulandavelu, Raul A. Dulce, Christopher I. Murray, Michael A. Bellio, Julia Fritsch, Rosemeire Kanashiro‐Takeuchi, Himanshu Arora, Ellena Paulino, Daniel Soetkamp, Wayne Balkan, Jenny E. Van Eyk, Joshua M. Hare
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 5 (2022)
Background Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is characterized by an increase in S‐nitrosylated proteins and reactive oxygen species, suggesting a pathophysiologic role for dysregulation in nitrosylation an
Externí odkaz:
https://doaj.org/article/7c58d4a5e22d48efa2ccc96e5a6e59bc
Autor:
Raul A Dulce, Rosemeire M Kanashiro-Takeuchi, Lauro M Takeuchi, Alessandro G Salerno, Amarylis C B A Wanschel, Shathiyah Kulandavelu, Wayne Balkan, Marilia S S R Zuttion, Renzhi Cai, Andrew V Schally, Joshua M Hare
Publikováno v:
Cardiovascular Research. 118:3586-3601
Aims To test the hypothesis that the activation of the growth hormone-releasing hormone (GHRH) receptor signalling pathway within the myocardium both prevents and reverses diastolic dysfunction and pathophysiologic features consistent with heart fail
Autor:
Rosemeire M. Kanashiro-Takeuchi, Lauro M. Takeuchi, Raul A. Dulce, Katarzyna Kazmierczak, Wayne Balkan, Renzhi Cai, Wei Sha, Andrew V. Schally, Joshua M. Hare
Heart failure (HF) with preserved ejection fraction (HFpEF) represents a major unmet medical need owing to its diverse pathophysiology and lack of effective therapies. Potent synthetic, agonists (MR-356 and MR409) of growth hormone-releasing hormone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5eb5724af07ef228e142b868993d34
https://doi.org/10.1101/2022.09.18.508429
https://doi.org/10.1101/2022.09.18.508429
Autor:
Manish Kuchakulla, Fakiha Firdaus, Rehana Qureshi, Yash Soni, Derek J Van Booven, Khushi Shah, Raul Ariel Dulce, Thomas Masterson, Omar Joel Rosete, Joshua M. Hare, Ranjith Ramasamy, Himanshu Arora
During progression of prostate cancer, sustained oxidative overload in cancer cells potentiates the overall tumor microenvironment (TME). Targeting the TME using colony-stimulating factor 1 receptor (CSF1R) inhibition is a promising therapy for castr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf7e612e2090717fbac46b653bb7e639
https://doi.org/10.1101/2022.06.09.495543
https://doi.org/10.1101/2022.06.09.495543
Autor:
Raul A, Dulce, Rosemeire M, Kanashiro-Takeuchi, Lauro M, Takeuchi, Alessandro G, Salerno, Amarylis C B A, Wanschel, Shathiyah, Kulandavelu, Wayne, Balkan, Marilia S S R, Zuttion, Renzhi, Cai, Andrew V, Schally, Joshua M, Hare
Publikováno v:
Cardiovasc Res
To test the hypothesis that the activation of the growth hormone-releasing hormone (GHRH) receptor signaling pathway within the myocardium both prevents and reverses diastolic dysfunction and pathophysiologic features consistent with heart failure wi
Autor:
Álvaro Valdés, Adriana V. Treuer, Guillermo Barrios, Nikol Ponce, Roberto Fuentealba, Raul A. Dulce, Daniel R. González
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2404 (2018)
Cardiac aging is characterized by alterations in contractility and intracellular calcium ([Ca2+]i) homeostasis. It has been suggested that oxidative stress may be involved in this process. We and others have reported that in cardiomyopathies the NADP
Externí odkaz:
https://doaj.org/article/be71a604e9884ab28a5e530547b08711
Autor:
Rosemeire M. Kanashiro-Takeuchi, Alessandro Salerno, Andrew V. Schally, Amarylis C. B. A. Wanschel, Peter Buchwald, Joshua M. Hare, Ivonne Hernandez Schulman, Raul A Dulce, Victoria Florea, Marcos Rosado, Darren Turner, Luiza Bagno, Wayne Balkan, Angela C. Rieger, Jose Rodriguez, Lauro M Takeuchi
Publikováno v:
Proc Natl Acad Sci U S A
Therapies for heart failure with preserved ejection fraction (HFpEF) are lacking. Growth hormone-releasing hormone agonists (GHRH-As) have salutary effects in ischemic and nonischemic heart failure animal models. Accordingly, we hypothesized that GHR
Autor:
Amarylis C. B. A. Wanschel, Raul A Dulce, Alessandro Salerno, Wayne Balkan, Joshua M. Hare, Konstantinos E. Hatzistergos
Publikováno v:
J Cardiovasc Aging
INTRODUCTION: Induced pluripotent stem cells (iPSCs) provide a model of cardiomyocyte (CM) maturation. Nitric oxide signaling promotes CM differentiation and maturation, although the mechanisms remain controversial. AIM: The study tested the hypothes
Autor:
Lauro M Takeuchi, Rosemeire M. Kanashiro-Takeuchi, Raul A Dulce, Renzhi Cai, Andrew V. Schally, Joshua M. Hare, Wayne Balkan, Alessandro Salerno
Publikováno v:
Circulation. 142
Introduction: Heart failure with preserved ejection fraction (HFpEF) accounts for ~50% of heart failure cases and is characterized by impaired relaxation, ventricular stiffening and fibrosis. Growth hormone releasing hormone-agonists (GHRH-As) reduce