Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions.

Autor: Robbins CS, Chudnovskiy A, Rauch PJ, Figueiredo JL, Iwamoto Y, Gorbatov R, Etzrodt M, Weber GF, Ueno T, van Rooijen N, Mulligan-Kehoe MJ, Libby P, Nahrendorf M, Pittet MJ, Weissleder R, Swirski FK, Robbins, Clinton S, Chudnovskiy, Aleksey, Rauch, Philipp J, Figueiredo, Jose-Luiz

Publikováno v: Circulation; 1/17/2012, Vol. 125 Issue 2, p364-374, 11p

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Loss-of-function mutations in Dnmt3a and Tet2 lead to accelerated atherosclerosis and concordant macrophage phenotypes.

Autor: Rauch PJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. philipp_rauch@dfci.harvard.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. philipp_rauch@dfci.harvard.edu., Gopakumar J; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Silver AJ; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Nachun D; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Ahmad H; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., McConkey M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Nakao T; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Bosse M; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Rentz T; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Vivanco Gonzalez N; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Greenwald NF; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., McCaffrey EF; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Khair Z; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Gopakumar M; Department of Electrical Engineering, Stanford University, Stanford, CA, USA., Rodrigues KB; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Lin AE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Sinha E; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Fefer M; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Cohen DN; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Vromman A; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Shvartz E; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Sukhova G; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Bendall S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Angelo M; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Libby P; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Ebert BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA., Jaiswal S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. sjaiswal@stanford.edu.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. sjaiswal@stanford.edu.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2023 Sep; Vol. 2 (9), pp. 805-818. Date of Electronic Publication: 2023 Sep 04.

Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts.

Autor: Ellegast JM; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Alexe G; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Bioinformatics Graduate Program, Boston University, Boston, Massachusetts., Hamze A; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Lin S; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Uckelmann HJ; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Rauch PJ; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Pimkin M; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Ross LS; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Dharia NV; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Robichaud AL; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Conway AS; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Khalid D; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Perry JA; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Wunderlich M; Division of Experimental Hematology and Cancer Biology, Cancer and Blood Disease Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Benajiba L; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; Université de Paris, INSERM U944 and CNRS 7212, Institut de Recherche Saint Louis, Hôpital Saint Louis, APHP, Paris, France., Pikman Y; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Nabet B; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington., Gray NS; Department of Chemical and Systems Biology, Chem-H and Stanford Cancer Institute, Stanford Medicine, Stanford University, Stanford, California., Orkin SH; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts., Stegmaier K; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

Publikováno v: Cancer discovery [Cancer Discov] 2022 Jul 06; Vol. 12 (7), pp. 1760-1781.