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Genomic Informational Field Theory (GIFT) to characterize genotypes involved in large phenotypic fluctuations

Autor: Rauch, Cyril, Kyratzi, Panagiota, Paldi, Andras

Based on the normal distribution and its properties, i.e., average and variance, Fisher works have provided a conceptual framework to identify genotype-phenotype associations. While Fisher intuition has proved fruitful over the past century, the curr

Externí odkaz: http://arxiv.org/abs/2307.02287

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Analysis of Genotype-Phenotype Association using Genomic Informational Field Theory (GIFT)

Autor: Wattis, Jonathan, Bray, Sian, Kyratzi, Panagiota, Rauch, Cyril

We show how field- and information theory can be used to quantify the relationship between genotype and phenotype in cases where phenotype is a continuous variable. Given a sample population of phenotype measurements, from various known genotypes, we

Externí odkaz: http://arxiv.org/abs/2202.11989

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Akademický článek

Proton dynamics in cancer

Autor: Pouysségur Jacques, Chiesi Antonio, Wahl Miriam L, Rauch Cyril, Reshkin Stephan J, Harguindey Salvador, De Milito Angelo, Huber Veronica, Gatenby Robert A, Rivoltini Licia, Fais Stefano

Publikováno v: Journal of Translational Medicine, Vol 8, Iss 1, p 57 (2010)

Abstract Cancer remains a leading cause of death in the world today. Despite decades of research to identify novel therapeutic approaches, durable regressions of metastatic disease are still scanty and survival benefits often negligible. While the cu

Externí odkaz: https://doaj.org/article/38819d0dc0a84e84b5b32b724079278b