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Real-world efficacy of treatment with Benralizumab, Dupilumab, Mepolizumab and Reslizumab for severe asthma: A systematic review and meta-analysis

Autor: Charles, David, Shanley, Jemma, Temple, Sasha-Nicole, Rattu, Anna, Khaleva, Ekaterina, Roberts, Graham

Background: severe asthma is a major cause of morbidity. Some patients may benefit from biological therapies. Most evaluations of these treatments are derived from randomized controlled trials (RCTs), but few patients are eligible for these trials. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______348::880aba3087dc69d3f236e76e7a8b5333
https://eprints.soton.ac.uk/455426/

Patient-centred composite scores as tools for assesment of response to biological therapy for paediatric and adult severe asthma.

Autor: Khaleva E; Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK doctor.khaleva@gmail.com.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Brightling C; Institute for Lung Health, Leicester NIHR BRC, University of Leicester, UK., Eiwegger T; Karl Landsteiner University of Health Sciences, Krems, Austria.; Translational Medicine Program, Research Institute, The Hospital for Sick Children, Toronto, Canada.; Department of Immunology, University of Toronto, Toronto, Canada.; Department of Pediatric and Adolescent Medicine, University Hospital St. Pölten, St. Pölten, Austria., Altraja A; Department of Pulmonology, University of Tartu and Lung Clinic, Tartu University Hospital, Tartu, Estonia., Bégin P; Department of Medicine, CHUM, Montréal. 2. Department of Pediatrics, CHU Ste-Justine, Montréal., Blumchen K; Department of Children and Adolescent Medicine, Division of Pneumology, Allergology and Cystic fibrosis, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany., Bossios A; Karolinska Severe Asthma Center, Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Huddinge, Sweden.; Division for Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Bourdin A; PhyMedExp, University of Montpellier, Montpellier, France., Ten Brinke A; Department of Respiratory Medicine, Medical Centre Leeuwarden, Leeuwarden, the Netherlands., Brusselle G; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Silvia Bumbacea R; Department of Allergology 'Carol Davila', University of Medicine and Pharmacy, Bucharest, Romania, Department of Allergology 'Dr. Carol Davila' Nephrology Clinical Hospital, Bucharest, Romania., Bush A; Centre for Paediatrics and Child Health and National Heart and Lung Institute, Imperial College; Royal Brompton Hospital, London, UK., Casale TB; Division of Allergy/Immunology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA., Clarke GW; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals, R&D, AstraZeneca.; School of Immunology & Microbial Sciences, King's College London, London, UK., Chaudhuri R; School of Infection & Immunity, University of Glasgow, Glasgow, UK., Fan Chung K; National Heart & Lung Institute, Imperial College London, London, UK., Coleman C; European Lung Foundation, Sheffield, UK., Corren J; David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Dahlén SE; Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Huddinge.; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Deschildre A; Univ Lille, CHU Lille, Unité de Pneumologie et Allergologie Pédiatrique, Hôpital Jeanne de Flandre F-59000 Lille, France.; U1019 - UMR 8204 - CIIL - Center for Infection and Immunity of Lille, Lille, France., Djukanovic R; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Eger K; Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Exley A; Adept Biologica Consulting Limited, London, UK., Fleming L; National Heart and Lung Institute, Imperial College, London., Fowler SJ; Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Infection, Immunity & Respiratory Medicine, The University of Manchester, and NIHR Manchester Biomedical Research Unit and Manchester University NHS Foundation Trust, Manchester, UK., Gaillard EA; University of Leicester, Department of Respiratory Sciences, Leicester NIHR Biomedical Research Centre (Respiratory theme), Leicester, UK., Gappa M; Department of Pediatrics, Evangelisches Krankenhaus Düsseldorf, Düsseldorf, Germany., Gupta A; Department of Paediatric Respiratory Medicine, King's College Hospital, London, UK., Michael Haitchi H; Respiratory Medicine Department, University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom.; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom., Hashimoto S; Department of Pediatric Respiratory Medicine and Allergy, Emma Children's Hospital, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Heaney LG; Wellcome-Wolfson Centre for Experimental Medicine School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, UK., Hedlin G; Department of Women's and Children's Health and Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden., Henderson M; European Federation of Allergy and Airways Diseases Patients' Associations, Brussels, Belgium., Hua W; Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, , China., Jackson DJ; King's Centre for Lung Health, King's College London.; Guy's Asthma Centre, Guy's & St Thomas' NHS Trust, London, UK., Karadag B; Marmara University Faculty of Medicine, Division of Pediatric Pulmonology, Istanbul, Turkey., Helen Katelaris C; Immunology and Allergy Unit Campbelltown Hospital and Western Sydney University Campbelltown, Sydney, Australia., Koh MS; Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore.; Duke- National University Singapore, Singapore., Volkmar Kopp M; University Children's Hospital of Bern, Inselspital, University of Bern, Bern, Switzerland.; Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany., Koppelman GH; University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, the Netherlands., Kull I; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden., Kurukulaaratchy RJ; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton.; NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton.; David Hide Asthma & Allergy Centre, St Mary's Hospital, Newport, Isle of Wight., Lee JH; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Mahler V; Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Division of Allergology, Langen, Germany., Mäkelä M; HUS Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Masoli M; University of Exeter, Royal Devon and Exeter Hospital, Exeter, United Kingdom., Mathioudakis AG; Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, UK.; North West Lung Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Mazon A; Unit of Pediatric Allergy and Pneumology, Health Research Institute La Fe, University and Polytechnic Hospital La Fe, Valencia, Spain., Melén E; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden., Milger K; Department of Medicine V, University Hospital, LMU Munich, Germany.; Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL)., Moeller A; Department of Respiratory Medicine, University Children's Hospital Zurich and Childhood Research Center, Zurich, Switzerland., Murray CS; Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Infection, Immunity and Respiratory Medicine, University of Manchester, NIHR Manchester Biomedical Research Unit, Manchester University NHS Foundation Trust, Manchester, UK., Nagakumar P; Department of Respiratory Medicine, Birmingham Children's Hospital, Steelhouse lane, Birmingham, UK.; Institute of Inflammation and Ageing, University of Birmingham., Nair P; Department of Medicine, Division of Respirology, St Joseph's Healthcare & McMaster University, Hamilton, Ontario, Canada., Negus J; 3TR respiratory working group, Brussels, Belgium., Nieto A; Pediatric Pulmonology & Allergy Unit, Health Reasearch Institute, Hospital la Fe, Valencia, Spain., Papadopoulos NG; Allergy Dpt, 2nd Pediatric Clinic, University of Athens, Athens, Greece.; Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK., Paton J; School of Medicine, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, UK., Pijnenburg MW; Erasmus MC - Sophia Children's Hospital, University Medical Centre Rotterdam, Department of Paediatrics/ Paediatric Respiratory Medicine and Allergology, Rotterdam, The Netherlands., Pike KC; Department of Paediatric Respiratory Medicine, Bristol Royal Hospital for Children, Bristol, UK., Porsbjerg C; Department of Respiratory Medicine, Respiratory Research Unit, Bispebjerg Hospital, Copenhagen, Denmark., Rattu A; Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK., Rupani H; Department of Respiratory Medicine, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Rusconi F; Department of Mother and Child Health, Azienda USL Toscana Nord Ovest, Pisa, Italy., Rutjes NW; Department of Pediatric Respiratory Medicine and Allergy, Emma Children's Hospital, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands., Saglani S; National Heart and Lung Institute, Imperial College London, UK., Seddon P; Respiratory Care, Royal Alexandra Children's Hospital, Brighton, UK., Siddiqui S; Imperial NIHR Biomedical Research Centre, National Lung and Heart Institute, Imperial College London, London, UK., Singer F; Department of Respiratory Medicine, University Children's Hospital Zurich and Childhood Research Center, Zurich, Switzerland.; Division of Paediatric Pulmonology and Allergology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Austria., Tajiri T; Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University School of Medical Sciences, Nagoya, Japan., Turner S; Women and children division, NHS Grampian, Aberdeen, UK; 2. Child Health, University of Aberdeen, Aberdeen, UK., Upham JW; Frazer Institute, The University of Queensland.; Princess Alexandra Hospital, Brisbane, Australia., Vijverberg SJH; Department of Pediatric Respiratory Medicine and Allergy, Emma Children's Hospital, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands.; Pulmonary Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Wark PAB; School of Translational Medicine, Monash University., Wechsler ME; NJH Cohen Family Asthma Institute, Department of Medicine, National Jewish Health, Denver, CO., Yasinska V; Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Huddinge and Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden., Roberts G; Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.; Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospital Foundation Trust, Southampton, UK.

Publikováno v: The European respiratory journal [Eur Respir J] 2024 Nov 21. Date of Electronic Publication: 2024 Nov 21.