Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ratneswary, Sutharsan"'
Autor:
Laura M. Rantanen, Maina Bitar, Riikka Lampinen, Romal Stewart, Hazel Quek, Lotta E. Oikari, Carla Cunί-Lόpez, Ratneswary Sutharsan, Gayathri Thillaiyampalam, Jamila Iqbal, Daniel Russell, Elina Penttilä, Heikki Löppönen, Juha-Matti Lehtola, Toni Saari, Sanna Hannonen, Anne M. Koivisto, Larisa M. Haupt, Alan Mackay-Sim, Alexandre S. Cristino, Katja M. Kanninen, Anthony R. White
Publikováno v:
Cells, Vol 11, Iss 20, p 3258 (2022)
An early symptom of Alzheimer’s disease (AD) is an impaired sense of smell, for which the molecular basis remains elusive. Here, we generated human olfactory neurosphere-derived (ONS) cells from people with AD and mild cognitive impairment (MCI), a
Externí odkaz:
https://doaj.org/article/dca05e7e61d14b3aa34487459c0f0668
Autor:
Gautam Wali, Erandhi Liyanage, Nicholas F. Blair, Ratneswary Sutharsan, Jin-Sung Park, Alan Mackay-Sim, Carolyn M. Sue
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Hereditary spastic paraplegia (HSP) is a group of inherited disorders characterized by progressive spasticity and paralysis of the lower limbs. Autosomal dominant mutations in SPAST gene account for ∼40% of adult-onset patients. We have previously
Externí odkaz:
https://doaj.org/article/80b5c527c6884da192ed4da05652fedf
Autor:
Liyu Chen, Ratneswary Sutharsan, Jonathan LF Lee, Esteban Cruz, Blaise Asnicar, Tishila Palliyaguru, Joanna M Wasielewska, Arnaud Gaudin, Jae Song, Gerhard Leinenga, Jürgen Götz
Publikováno v:
Theranostics. 12:1952-1970
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42bf218847d1935afccaed35ffd6b38d
https://doi.org/10.7150/thno.65539
https://doi.org/10.7150/thno.65539
Autor:
Laura M. Rantanen, Maina Bitar, Riikka Lampinen, Romal Stewart, Hazel Quek, Lotta E. Oikari, Carla Cunί-Lόpez, Ratneswary Sutharsan, Gayathri Thillaiyampalam, Jamila Iqbal, Daniel Russell, Elina Penttilä, Heikki Löppönen, Juha-Matti Lehtola, Toni Saari, Sanna Hannonen, Anne M Koivisto, Larisa M. Haupt, Alan Mackay-Sim, Alexandre S. Cristino, Katja M. Kanninen, Anthony R. White
An early symptom of Alzheimer’s disease (AD) is an impaired sense of smell, for which the molecular basis remains elusive. Here, we generated human olfactory neurosphere-derived (ONS) cells from people with AD and mild cognitive impairment (MCI), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::354e428e616eaf06921774d3cad236a1
https://doi.org/10.1101/2022.08.22.504884
https://doi.org/10.1101/2022.08.22.504884
Autor:
Yongjun Fan, Gautam Wali, Ratneswary Sutharsan, Bernadette Bellette, Denis I. Crane, Carolyn M. Sue, Alan Mackay-Sim
Publikováno v:
Biology Open, Vol 3, Iss 6, Pp 494-502 (2014)
Hereditary Spastic Paraplegia (HSP) is a genetically heterogeneous group of disorders, diagnosed by progressive gait disturbances with muscle weakness and spasticity, for which there are no treatments targeted at the underlying pathophysiology. Mutat
Externí odkaz:
https://doaj.org/article/0e25420270d44897989da33cb4a75dfe
Autor:
Greger Abrahamsen, Yongjun Fan, Nicholas Matigian, Gautam Wali, Bernadette Bellette, Ratneswary Sutharsan, Jyothy Raju, Stephen A. Wood, David Veivers, Carolyn M. Sue, Alan Mackay-Sim
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 2, Pp 489-502 (2013)
SUMMARY Hereditary spastic paraplegia (HSP) leads to progressive gait disturbances with lower limb muscle weakness and spasticity. Mutations in SPAST are a major cause of adult-onset, autosomal-dominant HSP. Spastin, the protein encoded by SPAST, is
Externí odkaz:
https://doaj.org/article/7aa64347ec6c4c11a36f50021d7c5f31
Claudin-5 binder enhances focused ultrasound-mediated opening in anin vitroblood-brain barrier model
Autor:
Blaise Asnicar, Tishila Palliyaguru, Gerhard Leinenga, Liyu Chen, Ratneswary Sutharsan, Jürgen Götz, Esteban Cruz, Jonathan Lf Lee
RationaleThe blood-brain barrier (BBB) while functioning as a gatekeeper of the brain, impedes cerebral drug delivery. An emerging technology to overcome this limitation is focused ultrasound (FUS). When FUS interacts with intravenously injected micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eec12422e84d260ca5976a65dc97e576
https://doi.org/10.1101/2021.08.01.454692
https://doi.org/10.1101/2021.08.01.454692
Autor:
Liyu, Chen, Ratneswary, Sutharsan, Jonathan Lf, Lee, Esteban, Cruz, Blaise, Asnicar, Tishila, Palliyaguru, Joanna M, Wasielewska, Arnaud, Gaudin, Jae, Song, Gerhard, Leinenga, Jürgen, Götz
Publikováno v:
Theranostics. 12(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b98c521cc6f7e87ac411d447687755b2
https://pubmed.ncbi.nlm.nih.gov/35265192
https://pubmed.ncbi.nlm.nih.gov/35265192
Autor:
Jin-Sung Park, Ratneswary Sutharsan, Nicholas F. Blair, Carolyn M. Sue, Alan Mackay-Sim, Gautam Wali, Erandhi Liyanage
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Hereditary spastic paraplegia (HSP) is a group of inherited disorders characterized by progressive spasticity and paralysis of the lower limbs. Autosomal dominant mutations in SPAST gene account for ∼40% of adult-onset patients. We have previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639e38d37449a23265a5d7f6bc495460
https://www.frontiersin.org/article/10.3389/fnins.2020.00401/full
https://www.frontiersin.org/article/10.3389/fnins.2020.00401/full
Autor:
Anthony L Cook, Alejandra M Vitale, Sugandha Ravishankar, Nicholas Matigian, Greg T Sutherland, Jiangou Shan, Ratneswary Sutharsan, Chris Perry, Peter A Silburn, George D Mellick, Murray L Whitelaw, Christine A Wells, Alan Mackay-Sim, Stephen A Wood
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21907 (2011)
Without appropriate cellular models the etiology of idiopathic Parkinson's disease remains unknown. We recently reported a novel patient-derived cellular model generated from biopsies of the olfactory mucosa (termed olfactory neurosphere-derived (hON
Externí odkaz:
https://doaj.org/article/eddc72fca9914912b35989eb6f387c41