Sub-nanowatt microfluidic single-cell calorimetry

Autor: Sahngki Hong, Edward Dechaumphai, Courtney R. Green, Ratneshwar Lal, Anne N. Murphy, Christian M. Metallo, Renkun Chen

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)

Calorimetrically measuring the heat of single cells is currently not possible due to the sensitivity of existing calorimeters. Here the authors present on-chip single cell calorimetry, with a sensitivity over ten-fold greater than the current gold-st

Externí odkaz: https://doaj.org/article/ddafd2d606444b99a889b410a3046e0e

Multifunctional stimuli responsive polymer-gated iron and gold-embedded silica nano golf balls: Nanoshuttles for targeted on-demand theranostics

Autor: Deependra Kumar Ban, Brian P. Head, Sami Kazmi, Vrinda Sant, Woraphong Janetanakit, Jay Seth, Nirav Patel, Shanshan Wang, Ratneshwar Lal, Joon Lee, Qingqing Yang, Grace Jang, Liping Wang, Gennadi V. Glinsky

Publikováno v: Bone research, vol 5, iss 1
Wang, L; Jang, G; Ban, DK; Sant, V; Seth, J; Kazmi, S; et al.(2017). Multifunctional stimuli responsive polymer-gated iron and gold-embedded silica nano golf balls: Nanoshuttles for targeted on-demand theranostics. BONE RESEARCH, 5. doi: 10.1038/boneres.2017.51. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/61p109x4
Bone Research

Multi-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis, efficient prevention and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19cd8d9eafa25ec298561382dfa6048f
https://doi.org/10.1038/boneres.2017.51

Elasticity and Adhesion Force Mapping Reveals Real-Time Clustering of Growth Factor Receptors and Associated Changes in Local Cellular Rheological Properties

Autor: G. Primbs, Ratneshwar Lal, R. Bhatia, N. Desai, Nils Almqvist, Sanjoy Banerjee

Publikováno v: Biophysical Journal. 86(3):1753-1762

Cell surface macromolecules such as receptors and ion channels serve as the interface link between the cytoplasm and the extracellular region. Their density, distribution, and clustering are key spatial features influencing effective and proper physi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5178cb49ef30128a002751f4ae766507

Imaging real-time aggregation of amyloid beta protein (1–42) by atomic force microscopy

Autor: Hai Lin, Julian Thimm, Ashok N. Parbhu, Ratneshwar Lal

Publikováno v: Peptides. 23:1265-1270

Amyloid beta protein (AbetaP) is the major fibrillar constituent of senile plaques. However, no causative role for AbetaP-fibers in Alzheimer's disease (AD) pathology is established. Globular AbetaPs are continuously released during normal cellular m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5b63e21bbbff5883fb7b70de88c1b3
https://doi.org/10.1016/s0196-9781(02)00061-x

Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology

Autor: Rajinder Bhatia, Ratneshwar Lal, Hai Lin

Publikováno v: The FASEB Journal. 15:2433-2444

Amyloid beta protein (AbetaP) is the major constituent of senile plaques associated with Alzheimer's disease (AD). However, its mechanistic role in AD pathogenesis is poorly understood. Globular and nonfibrillar AbetaPs are continuously released duri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a34e8b78bc9f6878bd869bd5ac2c1c
https://doi.org/10.1096/fj.01-0377com