Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment.

Autor: Ma J; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom.; Ministry of Health Holdings, Singapore 099253, Singapore., Al Moussawi K; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Lou H; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Chan HF; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Wang Y; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom.; Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom., Chadwick J; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Phetsouphanh C; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom.; The Kirby Institute, University of New South Wales, Kensington, NSW 2052, Australia., Slee EA; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Zhong S; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Leissing TM; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Roth A; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom.; Department of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 4E6, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z7, Canada.; Department of Computer Science, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Qin X; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom.; Department of Oncology, Faculty of Medical Sciences, University College London, London WC1E 6BT, United Kingdom., Chen S; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Yin J; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Ratnayaka I; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Hu Y; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Louphrasitthiphol P; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Taylor L; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom., Bettencourt PJG; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom.; Center for Interdisciplinary Research in Health, Faculty of Medicine, Universidade Católica Portuguesa, Lisbon 1649-023, Portugal., Muers M; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Greaves DR; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom., McShane H; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Goldin R; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London W2 1NY, United Kingdom., Soilleux EJ; Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom., Coleman ML; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom., Ratcliffe PJ; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom., Lu X; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Mar 05; Vol. 121 (10), pp. e2309957121. Date of Electronic Publication: 2024 Feb 29.

Venous identity requires BMP signalling through ALK3

Autor: Neal, A., Nornes, S., Payne, S., Wallace, M.D., Fritzsche, M., Louphrasitthiphol, P., Wilkinson, R.N., Chouliaras, K.M., Liu, K., Plant, K., Sholapurkar, R., Ratnayaka, I., Herzog, W., Bond, G., Chico, T., Bou-Gharios, G., De Val, S.

Publikováno v: Nature Communications
Nature communications
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)

Venous endothelial cells are molecularly and functionally distinct from their arterial counterparts. Although veins are often considered the default endothelial state, genetic manipulations can modulate both acquisition and loss of venous fate, sugge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::88511b3ddaee698b5f7e8ba1cd129287
http://europepmc.org/articles/PMC6349860

An intronic Flk1 enhancer directs arterial-specific expression via RBPJ-mediated venous repression

Autor: Becker, PW, Sacilotto, N, Nornes, S, Neal, A, Thomas, MO, Liu, K, Preece, C, Ratnayaka, I, Davies, B, Bou-Gharios, G, De Val, S

Publikováno v: Arteriosclerosis, Thrombosis and Vascular Biology

Objective—The vascular endothelial growth factor (VEGF) receptor Flk1 is essential for vascular development, but the signaling and transcriptional pathways by which its expression is regulated in endothelial cells remain unclear. Although previous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::899d2f31ea0ea661f1456a57ff094669
http://ora.ox.ac.uk/objects/uuid:3a9f9d37-ae63-48ef-8311-3cdb452a8cd6

Maternal Vitamin B12 in Pregnancy and Placental Development.

Autor: Arcot, Amrita¹ (AUTHOR), Walker, Rachel E.¹ (AUTHOR), Gallagher, Kelly² (AUTHOR), Klatt, Kevin C.³ (AUTHOR), Gernand, Alison D.¹ (AUTHOR) adg14@psu.edu, Wu, Qingqing (AUTHOR)

Publikováno v: Journal of Nutrition & Metabolism. 8/8/2024, Vol. 2024, p1-14. 14p.

PHD1-3 oxygen sensors in vivo-lessons learned from gene deletions.

Autor: Jucht AE; Institute of Physiology, University of Zurich, Zurich, 8057, Switzerland., Scholz CC; Institute of Physiology, University Medicine Greifswald, Friedrich-Ludwig-Jahn-Str. 15a, 17475, Greifswald, Germany. carsten.scholz@med.uni-greifswald.de.

Publikováno v: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2024 Sep; Vol. 476 (9), pp. 1307-1337. Date of Electronic Publication: 2024 Mar 21.