Výsledky vyhledávání - "Ratna C. Mehta"

1-Benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diols as novel affinity and photoaffinity probes for β-adrenoceptor subtypes

Autor: Dennis R. Feller, Duane D. Miller, Igor M. Rakov, Joseph E. De Los Angeles, LeNe’Sheya Y. Boyd, Ratna C. Mehta, Victor I. Nikulin

Publikováno v: Bioorganic & Medicinal Chemistry. 14:1684-1697

Trimetoquinol (TMQ, 1 ) is a potent non-selective β-adrenoceptor (β-AR) agonist possessing a tetrahydroisoquinoline (THI) structure. The binding site for 1-trimethoxybenzyl group of 1 , which distinguishes it from classical catecholamines, is unkno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d658fe55ac4c2a4204d7801d56d953a6
https://doi.org/10.1016/j.bmc.2005.12.027

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Biochemical and functional characterization of 1-benzyl substituted trimetoquinol affinity analogs on rat and human beta-adrenoceptors

Autor: Paul F. Fraundorfer, Victor I. Nikulin, Dennis R. Feller, Duane D. Miller, Joseph E. De Los Angeles, Ratna C. Mehta, M. Margarita Salazar‐Bookaman, Richard H. Fertel

Publikováno v: Biochemical pharmacology. 59(5)

The site of interaction for the 1-(3',4',5'-trimethoxybenzyl) group of trimetoquinol (TMQ) with beta-adrenoceptors (beta-ARs) is important for the rational design of highly potent and beta3-AR-selective analogs. 1-Benzyl ring-substituted TMQ analogs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2112ad7d30cef217088c03bd9df929a
https://pubmed.ncbi.nlm.nih.gov/10660118

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