Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Ratmir Derda"'
Autor:
Jeffrey Y. K. Wong, Arunika I. Ekanayake, Serhii Kharchenko, Steven E. Kirberger, Ryan Qiu, Payam Kelich, Susmita Sarkar, Jiaqian Li, Kleinberg X. Fernandez, Edgar R. Alvizo-Paez, Jiayuan Miao, Shiva Kalhor-Monfared, J. Dwyer John, Hongsuk Kang, Hwanho Choi, John M. Nuss, John C. Vederas, Yu-Shan Lin, Matthew S. Macauley, Lela Vukovic, William C. K. Pomerantz, Ratmir Derda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Peptide-based therapeutics have gained attention as promising therapeutic modalities, however, their prevalent drawback is poor circulation half-life in vivo. In this paper, we report the selection of albumin-binding macrocyclic peptides fro
Externí odkaz:
https://doaj.org/article/70cf58a7e9004f0fbc1e0c30b3084ed6
Autor:
Chih-Lan Lin, Mirat Sojitra, Eric J. Carpenter, Ellen S. Hayhoe, Susmita Sarkar, Elizabeth A. Volker, Chao Wang, Duong T. Bui, Loretta Yang, John S. Klassen, Peng Wu, Matthew S. Macauley, Todd L. Lowary, Ratmir Derda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cellular glycosylation is characterized by chemical complexity and heterogeneity, which is challenging to reproduce synthetically. Here we show chemoenzymatic synthesis on phage to produce a genetically-encoded liquid glycan array (LiGA) of
Externí odkaz:
https://doaj.org/article/da21baab0c17465c9c943d4e2e9add04
Autor:
Edward N. Schmidt, Dimitra Lamprinaki, Kelli A. McCord, Maju Joe, Mirat Sojitra, Ayk Waldow, Jasmine Nguyen, John Monyror, Elena N. Kitova, Fahima Mozaneh, Xue Yan Guo, Jaesoo Jung, Jhon R. Enterina, Gour C. Daskhan, Ling Han, Amanda R. Krysler, Christopher R. Cromwell, Basil P. Hubbard, Lori J. West, Marianne Kulka, Simonetta Sipione, John S. Klassen, Ratmir Derda, Todd L. Lowary, Lara K. Mahal, Meghan R. Riddell, Matthew S. Macauley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Immunomodulatory Siglecs are controlled by their glycoprotein and glycolipid ligands. Siglec-glycolipid interactions are often studied outside the context of a lipid bilayer, missing the complex behaviors of glycolipids in a membrane. Throug
Externí odkaz:
https://doaj.org/article/1b849c2f9a814c4e9507f12b5f5f0d43
Autor:
Jeffrey Y. K. Wong, Arunika I. Ekanayake, Serhii Kharchenko, Steven E. Kirberger, Ryan Qiu, Payam Kelich, Susmita Sarkar, Jiaqian Li, Kleinberg X. Fernandez, Edgar R. Alvizo-Paez, Jiayuan Miao, Shiva Kalhor-Monfared, J. Dwyer John, Hongsuk Kang, Hwanho Choi, John M. Nuss, John C. Vederas, Yu-Shan Lin, Matthew S. Macauley, Lela Vukovic, William C. K. Pomerantz, Ratmir Derda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/71139748923945fe95b7a358e1ee3960
Autor:
Benjamin M Scott, Wadim L Matochko, Richard F Gierczak, Varsha Bhakta, Ratmir Derda, William P Sheffield
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238969 (2020)
[This corrects the article DOI: 10.1371/journal.pone.0084491.].
Externí odkaz:
https://doaj.org/article/4e70cb041e254a179dfb17ba66abac10
Publikováno v:
Molecules, Vol 16, Iss 2, Pp 1776-1803 (2011)
The amplification of phage-displayed libraries is an essential step in the selection of ligands from these libraries. The amplification of libraries, however, decreases their diversity and limits the number of binding clones that a screen can identif
Externí odkaz:
https://doaj.org/article/506e84cef7ff444cb38eb43d4d78e53f
Autor:
Ratmir Derda, Jesse Gitaka, Catherine M Klapperich, Charles R Mace, Ashok A Kumar, Marya Lieberman, Jacqueline C Linnes, Joerg Jores, Johnson Nasimolo, Joseph Ndung'u, Evans Taracha, Abigail Weaver, Douglas B Weibel, Thomas M Kariuki, Paul Yager
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 5, p e0003676 (2015)
Externí odkaz:
https://doaj.org/article/92739970d70b48d59f98385a99dfd87a
Autor:
Benjamin M Scott, Wadim L Matochko, Richard F Gierczak, Varsha Bhakta, Ratmir Derda, William P Sheffield
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84491 (2014)
In spite of the power of phage display technology to identify variant proteins with novel properties in large libraries, it has only been previously applied to one member of the serpin superfamily. Here we describe phage display of human alpha-1 prot
Externí odkaz:
https://doaj.org/article/1317fe9f2b7c41d39d75a8490d84eb83
Autor:
Ratmir Derda, Sindy K Y Tang, Anna Laromaine, Bobak Mosadegh, Estrella Hong, Martin Mwangi, Akiko Mammoto, Donald E Ingber, George M Whitesides
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e18940 (2011)
In vitro 3D culture is an important model for tissues in vivo. Cells in different locations of 3D tissues are physiologically different, because they are exposed to different concentrations of oxygen, nutrients, and signaling molecules, and to other
Externí odkaz:
https://doaj.org/article/3b23e15a6e4644b98b571daaa94ae54e
Autor:
Matthew G. Alteen, Richard W. Meek, Subramania Kolappan, Jil A. Busmann, Jessica Cao, Zoe O’Gara, Ratmir Derda, Gideon J. Davies, David J. Vocadlo
The modification of nucleocytoplasmic proteins by O-linked N-acetylglucosamine (O-GlcNAc) is an important regulator of cell physiology.O-GlcNAc is installed on over a thousand proteins by just one enzyme,O-GlcNAc transferase (OGT). How OGT is therefo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81dd377a6e2733658f09951930ef9984
https://doi.org/10.1101/2023.03.15.532872
https://doi.org/10.1101/2023.03.15.532872
