Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Ratmir, Derda"'
Autor:
Jeffrey Y. K. Wong, Arunika I. Ekanayake, Serhii Kharchenko, Steven E. Kirberger, Ryan Qiu, Payam Kelich, Susmita Sarkar, Jiaqian Li, Kleinberg X. Fernandez, Edgar R. Alvizo-Paez, Jiayuan Miao, Shiva Kalhor-Monfared, J. Dwyer John, Hongsuk Kang, Hwanho Choi, John M. Nuss, John C. Vederas, Yu-Shan Lin, Matthew S. Macauley, Lela Vukovic, William C. K. Pomerantz, Ratmir Derda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Peptide-based therapeutics have gained attention as promising therapeutic modalities, however, their prevalent drawback is poor circulation half-life in vivo. In this paper, we report the selection of albumin-binding macrocyclic peptides fro
Externí odkaz:
https://doaj.org/article/70cf58a7e9004f0fbc1e0c30b3084ed6
Autor:
Chih-Lan Lin, Mirat Sojitra, Eric J. Carpenter, Ellen S. Hayhoe, Susmita Sarkar, Elizabeth A. Volker, Chao Wang, Duong T. Bui, Loretta Yang, John S. Klassen, Peng Wu, Matthew S. Macauley, Todd L. Lowary, Ratmir Derda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cellular glycosylation is characterized by chemical complexity and heterogeneity, which is challenging to reproduce synthetically. Here we show chemoenzymatic synthesis on phage to produce a genetically-encoded liquid glycan array (LiGA) of
Externí odkaz:
https://doaj.org/article/da21baab0c17465c9c943d4e2e9add04
Autor:
Edward N. Schmidt, Dimitra Lamprinaki, Kelli A. McCord, Maju Joe, Mirat Sojitra, Ayk Waldow, Jasmine Nguyen, John Monyror, Elena N. Kitova, Fahima Mozaneh, Xue Yan Guo, Jaesoo Jung, Jhon R. Enterina, Gour C. Daskhan, Ling Han, Amanda R. Krysler, Christopher R. Cromwell, Basil P. Hubbard, Lori J. West, Marianne Kulka, Simonetta Sipione, John S. Klassen, Ratmir Derda, Todd L. Lowary, Lara K. Mahal, Meghan R. Riddell, Matthew S. Macauley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Immunomodulatory Siglecs are controlled by their glycoprotein and glycolipid ligands. Siglec-glycolipid interactions are often studied outside the context of a lipid bilayer, missing the complex behaviors of glycolipids in a membrane. Throug
Externí odkaz:
https://doaj.org/article/1b849c2f9a814c4e9507f12b5f5f0d43
Autor:
Jeffrey Y. K. Wong, Arunika I. Ekanayake, Serhii Kharchenko, Steven E. Kirberger, Ryan Qiu, Payam Kelich, Susmita Sarkar, Jiaqian Li, Kleinberg X. Fernandez, Edgar R. Alvizo-Paez, Jiayuan Miao, Shiva Kalhor-Monfared, J. Dwyer John, Hongsuk Kang, Hwanho Choi, John M. Nuss, John C. Vederas, Yu-Shan Lin, Matthew S. Macauley, Lela Vukovic, William C. K. Pomerantz, Ratmir Derda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/71139748923945fe95b7a358e1ee3960
Autor:
Benjamin M Scott, Wadim L Matochko, Richard F Gierczak, Varsha Bhakta, Ratmir Derda, William P Sheffield
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238969 (2020)
[This corrects the article DOI: 10.1371/journal.pone.0084491.].
Externí odkaz:
https://doaj.org/article/4e70cb041e254a179dfb17ba66abac10
Autor:
Matthew G. Alteen, Richard W. Meek, Subramania Kolappan, Jil A. Busmann, Jessica Cao, Zoe O’Gara, Ratmir Derda, Gideon J. Davies, David J. Vocadlo
The modification of nucleocytoplasmic proteins by O-linked N-acetylglucosamine (O-GlcNAc) is an important regulator of cell physiology.O-GlcNAc is installed on over a thousand proteins by just one enzyme,O-GlcNAc transferase (OGT). How OGT is therefo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81dd377a6e2733658f09951930ef9984
https://doi.org/10.1101/2023.03.15.532872
https://doi.org/10.1101/2023.03.15.532872
Autor:
Guilherme M. Lima, Alexey Atrazhev, Susmita Sarkar, Mirat Sojitra, Revathi Reddy, Karin Torres-Obreque, Carlota de Oliveira Rangel-Yagui, Matthew S. Macauley, Gisele Monteiro, Ratmir Derda
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::439d02e5765c165947b71a925dc7c685
https://doi.org/10.1021/acschembio.1c00835
https://doi.org/10.1021/acschembio.1c00835
Autor:
Russell Greiner, Vivian Triana, Ratmir Derda, Alex Brown, Sunil V. Kalmady, Sharyar Memon, Kejia Yan, Kwami Aku-Dominguez
Publikováno v:
Chemical Science
The Wittig reaction can be used for late stage functionalization of proteins and peptides to ligate glycans, pharmacophores, and many other functionalities. In this manuscript, we modified 160 000 N-terminal glyoxaldehyde peptides displayed on phage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e651e0578a2100b09b89726a64b55bf0
http://europepmc.org/articles/PMC8565473
http://europepmc.org/articles/PMC8565473
Autor:
Jeffrey Wong, Steven Kirberger, Ryan Qiu, Arunika Ekanayake, Payam Kelich, Susmita Sarkar, Edgar Alvizo-Paez, Jiayuan Miao, Shiva Kalhor-Monfared, John Dwyer, John Nuss, Yu-Shan Lin, Matthew Macauley, Lela Vukovic, William Pomerantz, Ratmir Derda
In this paper, we report selection of albumin-binding macrocyclic peptides from genetically encoded libraries of peptides modified by perfluoroaryl-cysteine SNAr chemistry. Modification of phage-displayed libraries SXCXnC-phage, n = 3–5, where X is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9c83207bcfd9b101d12d915f29dcaca
https://doi.org/10.21203/rs.3.rs-1999287/v1
https://doi.org/10.21203/rs.3.rs-1999287/v1
Autor:
Chih-Lan Lin, Mirat Sojitra, Eric Carpenter, Ellen Hayhoe, Susmita Sarkar, Elizabeth Volker, Alexei Atrazhev, Todd Lowary, Matthew Macauley, Ratmir Derda
A hallmark of cellular glycosylation is its chemical complexity and heterogeneity, which can be challenging to capture synthetically. Using chemoenzymatic synthesis on M13 phage, we produce a genetically-encoded liquid glycan array (LiGA) of biantenn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e864efeb0da093119ad3462bf6fab5e
https://doi.org/10.21203/rs.3.rs-1995604/v1
https://doi.org/10.21203/rs.3.rs-1995604/v1