Zobrazeno 1 - 10
of 383
pro vyhledávání: '"Ratko, Djukanovic"'
Autor:
Phillip D. Monk, Jody L. Brookes, Victoria J. Tear, Toby N. Batten, Clare Newall, Marcin Mankowski, Michael G. Crooks, Dave Singh, Rekha Chaudhuri, Brian Leaker, Kerry Lunn, Sophie Reynolds, Sarah Dudley, Felicity J. Gabbay, Stephen T. Holgate, Ratko Djukanovic, Thomas MA Wilkinson
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Respiratory viral infections are major drivers of chronic obstructive pulmonary disease (COPD) exacerbations. Interferon-β is naturally produced in response to viral infection, limiting replication. This exploratory study aimed t
Externí odkaz:
https://doaj.org/article/0e45758b1a514217839b388bd5252764
Autor:
Nazanin Zounemat Kermani, Chuan‐Xing Li, Ali Versi, Yusef Badi, Kai Sun, Mahmoud I Abdel‐Aziz, Martina Bonatti, Anke‐Hilse Maitland‐van der Zee, Ratko Djukanovic, Åsa Wheelock, Sven‐Erik Dahlen, Peter Howarth, Yike Guo, Kian Fan Chung, Ian M. Adcock, U‐BIOPRED Project Team
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 7, Pp n/a-n/a (2024)
Abstract Background Clustering approaches using single omics platforms are increasingly used to characterise molecular phenotypes of eosinophilic and neutrophilic asthma. Effective integration of multi‐omics platforms should lead towards greater re
Externí odkaz:
https://doaj.org/article/4594abc44bb74697a360cdab74ef0794
Autor:
Ahilanandan Dushianthan, Howard W. Clark, David Brealey, Danny Pratt, James B. Fink, Jens Madsen, Helen Moyses, Lewis Matthews, Tracy Hussell, Ratko Djukanovic, Martin Feelisch, Anthony D. Postle, Michael P. W. Grocott
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract SARS-CoV-2 directly targets alveolar epithelial cells and can lead to surfactant deficiency. Early reports suggested surfactant replacement may be effective in improving outcomes. The aim of the study to assess the feasibility and efficacy o
Externí odkaz:
https://doaj.org/article/a77d36c23f7d4e1287d0bc5878c169f2
Autor:
Khezia Asamoah, Kian Fan Chung, Nazanin Zounemat Kermani, Barbara Bodinier, Sven-Erik Dahlen, Ratko Djukanovic, Pankaj K. Bhavsar, Ian M. Adcock, Dragana Vuckovic, Marc Chadeau-Hyam
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104936- (2024)
Summary: Background: Eosinophilic and neutrophilic asthma defined by high levels of blood and sputum eosinophils and neutrophils exemplifies the inflammatory heterogeneity of asthma, particularly severe asthma. We analysed the serum and sputum proteo
Externí odkaz:
https://doaj.org/article/9d60fe4ea80c4d5ebe54f572eafa9d2e
Autor:
Apostolos Bossios, Alison M. Bacon, Katrien Eger, Dóra Paróczai, Florence Schleich, Shane Hanon, Svetlana Sergejeva, Eleftherios Zervas, Konstantinos Katsoulis, Christina Aggelopoulou, Konstantinos Kostikas, Eleni Gaki, Nikoletta Rovina, Zsuzsanna Csoma, Ineta Grisle, Kristina Bieksiené, Jolita Palacionyte, Anneke ten Brinke, Simone Hashimoto, Florin Mihălţan, Natalia Nenasheva, Biljana Zvezdin, Ivan Čekerevac, Sanja Hromiš, Vojislav Ćupurdija, Zorica Lazic, Rekha Chaudhuri, Steven James Smith, Hitasha Rupani, Hans Michael Haitchi, Ramesh Kurukulaaratchy, Olivia Fulton, Betty Frankemölle, Peter Howarth, Celeste Porsbjerg, Elisabeth H. Bel, Ratko Djukanovic, Michael E. Hyland
Publikováno v:
ERJ Open Research, Vol 9, Iss 6 (2023)
Background Vaccination is vital for achieving population immunity to severe acute respiratory syndrome coronavirus 2, but vaccination hesitancy presents a threat to achieving widespread immunity. Vaccine acceptance in chronic potentially immunosuppre
Externí odkaz:
https://doaj.org/article/ad4e9a83a4964481ba5e0939f42fb841
Autor:
Valentyna Yasinska, Cristina Gómez, Johan Kolmert, Magnus Ericsson, Anton Pohanka, Anna James, Lars I. Andersson, Maria Sparreman-Mikus, Ana R. Sousa, John H. Riley, Stewart Bates, Per S. Bakke, Nazanin Zounemat Kermani, Massimo Caruso, Pascal Chanez, Stephen J. Fowler, Thomas Geiser, Peter H. Howarth, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Annelie Behndig, Dominick E. Shaw, Richard G. Knowles, Barbro Dahlén, Anke-Hilse Maitland-van der Zee, Peter J. Sterk, Ratko Djukanovic, Ian M. Adcock, Kian Fan Chung, Craig E. Wheelock, Sven-Erik Dahlén, Eva Wikström Jonsson, H. Ahmed
Publikováno v:
ERJ Open Research, Vol 9, Iss 5 (2023)
Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthma has not p
Externí odkaz:
https://doaj.org/article/a7fc69aad4384962865d87d94aff46ed
Autor:
Stefania Principe, Levi B. Richards, Simone Hashimoto, Johannes Anthon Kroes, Job J.M.H. Van Bragt, Susanne J. Vijverberg, Jacob K. Sont, Nicola Scichilone, Kristina Bieksiene, Anneke Ten Brinke, Zsuzsanna Csoma, Barbro Dahlén, Bilun Gemicioglu, Ineta Grisle, Piotr Kuna, Zorica Lazic, Florin Mihaltan, Sanja Popović-Grle, Sabina Škrgat, Alessandro Marcon, Marco Caminati, Ratko Djukanovic, Celeste Porsbjerg, Anke-Hilse Maitland Van Der Zee
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2023)
Background The use of anti-interleukin-5 (IL5) for severe asthma is based on criteria from randomised controlled trials (RCTs), but in real-life patients might not fulfil the eligibility criteria but may benefit from biologics. We aimed to characteri
Externí odkaz:
https://doaj.org/article/352cbfdad2894a888d1e292ee4777930
Autor:
Ekaterina Khaleva, Anna Rattu, Chris Brightling, Andrew Bush, Arnaud Bourdin, Apostolos Bossios, Kian Fan Chung, Rekha Chaudhuri, Courtney Coleman, Ratko Djukanovic, Sven-Erik Dahlén, Andrew Exley, Louise Fleming, Stephen J. Fowler, Atul Gupta, Eckard Hamelmann, Gerard H. Koppelman, Erik Melén, Vera Mahler, Paul Seddon, Florian Singer, Celeste Porsbjerg, Valeria Ramiconi, Franca Rusconi, Valentyna Yasinska, Graham Roberts
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2023)
Background Biologics have proven efficacy for patients with severe asthma but there is lack of consensus on defining response. We systematically reviewed and appraised methodologically developed, defined and evaluated definitions of non-response and
Externí odkaz:
https://doaj.org/article/c9344bc69fde4a8d913ebd3dd5f62d8b
Autor:
Benjamin Gaston, Donna D. Gardner, Kenzie Mahan, Praveen Akuthota, Eneida A. Mendonca, Hannah Durrington, Nadzeya Marozkina, Rocio T. Martinez-Nunez, Dawn Newcomb, Benjamin Ainsworth, Arthur H. Owora, Kian Fan Chung, Samantha Walker, Stephen J. Fowler, Salman Siddiqui, Tonya Winders, Joe Zein, Nizar Jarjour, Yvonne J. Huang, Katherine N. Cahill, Ratko Djukanovic
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2023)
Background Many patients have uncontrolled asthma despite available treatments. Most of the new asthma therapies have focused on type 2 (T2) inflammation, leaving an unmet need for innovative research into mechanisms of asthma beyond T2 and immunity.
Externí odkaz:
https://doaj.org/article/8f20c591769241669a5d4467cb34426b
Autor:
Ben Ainsworth, Eleanor Chatburn, Aruna T. Bansal, Olivia Fulton, Dominique Hamerlijnck, Courtney Coleman, Katrien Eger, Michael Hyland, Joshua Holmes, Liam Heaney, Vratislav Sedlák, Sabina Škrgat, Natalija Edelbaher, Anneke ten Brinke, Celeste Porsbjerg, Mina Gaga, Claudia Loureiro, Ratko Djukanovic, Emmanuelle Berret, Namhee Kwon
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2023)
Introduction Severe asthma is a complex, multidimensional disease. Optimal treatment, adherence and outcomes require shared decision-making, rooted in mutual understanding between patient and clinician. This study used a novel, patient-centred approa
Externí odkaz:
https://doaj.org/article/d74f0e8e5d394494b5d21b42499f65d7