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Autor:
Ben Nicholas, Hyun-Hee Lee, Jane Guo, Milenko Cicmil, Cornelia Blume, René De Waal Malefyt, Ratko Djukanović
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Asthmatics are more susceptible to viral infections than healthy individuals and are known to have impaired innate anti-viral defences. Influenza A virus causes significant morbidity and mortality in this population. Immuno-modulatory regulators (IMR
Externí odkaz:
https://doaj.org/article/56be0a81d60549fab7bf0480d2859b0b
Autor:
Ling-Pei Ho, Liam G Heaney, Ran Wang, Chris Brightling, Joanna Porter, Stefan J Marciniak, Tom Wilkinson, Jane C Davies, Laurence Pearmain, Alex R Horsley, Lorcan P McGarvey, Ratko Djukanović, Nick Schindler, Sean Knight, Miriam Bennett, Rebecca C Robey, Tracy Hussell
Publikováno v:
BMJ Open Respiratory Research, Vol 9, Iss 1 (2022)
Background The COVID-19 pandemic has presented substantial new challenges to clinical and research teams. Our objective was to analyse the experience of investigators and research delivery staff regarding the research response to COVID-19 in order to
Externí odkaz:
https://doaj.org/article/752596b5ea4e496192277c545c4c7e49
Autor:
Alen Faiz, Stelios Pavlidis, Chih-Hsi Kuo, Anthony Rowe, Pieter S Hiemstra, Wim Timens, Marijn Berg, Marissa Wisman, Yi-Ke Guo, Ratko Djukanović, Peter Sterk, Kerstin B Meyer, Martijn C Nawijn, Ian Adcock, Kian Fan Chung, Maarten van den Berge
Publikováno v:
Thorax, 78:217736, 335-343. BMJ PUBLISHING GROUP
Thorax. BMJ PUBLISHING GROUP
Thorax
Thorax. BMJ Publishing Group
Thorax. BMJ PUBLISHING GROUP
Thorax
Thorax. BMJ Publishing Group
RationaleSevere asthma and chronic obstructive pulmonary disease (COPD) share common pathophysiological traits such as relative corticosteroid insensitivity. We recently published three transcriptome-associated clusters (TACs) using hierarchical anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9659e5c1de14cf2701639381476a77eb
https://hdl.handle.net/1887/3565018
https://hdl.handle.net/1887/3565018
Autor:
Alex R Horsley, Laurence Pearmain, Sean Knight, Nick Schindler, Ran Wang, Miriam Bennett, Rebecca C Robey, Jane C Davies, Ratko Djukanović, Liam G Heaney, Tracy Hussell, Stefan J Marciniak, Lorcan P McGarvey, Joanna Porter, Tom Wilkinson, Chris Brightling, Ling-Pei Ho
Publikováno v:
Horsley, A R, Pearmain, L, Knight, S, Schindler, N, Wang, R, Bennett, M, Robey, R C, Davies, J C, Djukanović, R, Heaney, L G, Hussell, T, Marciniak, S J, McGarvey, L P, Porter, J, Wilkinson, T, Brightling, C & Ho, L-P 2022, ' Large scale clinical trials: lessons from the COVID-19 pandemic ', BMJ Open Respiratory Research, vol. 9, no. 1, e001226 . https://doi.org/10.1136/bmjresp-2022-001226
Horsley, A, Pearmain, L, Knight, S, Schindler, N, Wang, R, Bennett, M, Robey, R, Davies, J C, Djukanovic, R, Heaney, L G, Hussell, T, Marciniak, S J, McGarvey, L, Porter, J C, Wilkinson, T, Brightling, C & Ho, L-P 2022, ' Large scale clinical trials: lessons from the COVID-19 pandemic ', BMJ Open Respiratory Research, vol. 9, no. 1, e001226 . https://doi.org/10.1136/bmjresp-2022-001226
Horsley, A, Pearmain, L, Knight, S, Schindler, N, Wang, R, Bennett, M, Robey, R, Davies, J C, Djukanovic, R, Heaney, L G, Hussell, T, Marciniak, S J, McGarvey, L, Porter, J C, Wilkinson, T, Brightling, C & Ho, L-P 2022, ' Large scale clinical trials: lessons from the COVID-19 pandemic ', BMJ Open Respiratory Research, vol. 9, no. 1, e001226 . https://doi.org/10.1136/bmjresp-2022-001226
BackgroundThe COVID-19 pandemic has presented substantial new challenges to clinical and research teams. Our objective was to analyse the experience of investigators and research delivery staff regarding the research response to COVID-19 in order to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3220f60c56cd8fbb4561e26704bdb50
https://pure.qub.ac.uk/en/publications/097e4008-86d0-4dd3-835d-9879066e70e1
https://pure.qub.ac.uk/en/publications/097e4008-86d0-4dd3-835d-9879066e70e1
Autor:
Karl J Staples, Ben Nicholas, Richard T McKendry, C Mirella Spalluto, Joshua C Wallington, Craig W Bragg, Emily C Robinson, Kirstin Martin, Ratko Djukanović, Tom M A Wilkinson
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121527 (2015)
Lung macrophages are an important defence against respiratory viral infection and recent work has demonstrated that influenza-induced macrophage PDL1 expression in the murine lung leads to rapid modulation of CD8+ T cell responses via the PD1 recepto
Externí odkaz:
https://doaj.org/article/7d746146d0234b05942328a759da58d1
Autor:
Mohib Uddin, Laurie C Lau, Grégory Seumois, Pandurangan Vijayanand, Karl J Staples, Dinesh Bagmane, Victoria Cornelius, Paul Dorinsky, Donna E Davies, Ratko Djukanović
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72502 (2013)
Chronic damage and repair of the bronchial epithelium are features of asthma. We have previously reported that ex vivo stimulation of normal bronchial epithelial cells with epidermal growth factor (EGF), a key factor of epithelial repair, enhances th
Externí odkaz:
https://doaj.org/article/68474176abe143ec8bf927d5d769a0ca
Autor:
Jörgen Östling, Marleen van Geest, James P.R. Schofield, Zala Jevnikar, Susan Wilson, Jonathan Ward, Rene Lutter, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Sven-Erik Dahlen, Stephen J. Fowler, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Kai Sun, Ioannis Pandis, Charles Auffray, Ana R. Sousa, Yike Guo, Ian M. Adcock, Peter Howarth, Kian Fan Chung, Jeanette Bigler, Peter J. Sterk, Paul J. Skipp, Ratko Djukanović, Outi Vaarala, I.M. Adcock, H. Ahmed, C. Auffray, P. Bakke, A.T. Bansal, F. Baribaud, S. Bates, E.H. Bel, J. Bigler, H. Bisgaard, M.J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, M. Caruso, A. Chaiboonchoe, P. Chanez, K.F. Chung, C.H. Compton, J. Corfield, A. D'Amico, S.E. Dahlen, B. De Meulder, R. Djukanovic, V.J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L.J. Fleming, E. Formaggio, S.J. Fowler, U. Frey, M. Gahlemann, T. Geiser, Y. Guo, S. Hashimoto, J. Haughney, G. Hedlin, P.W. Hekking, T. Higenbottam, J.M. Hohlfeld, C. Holweg, I. Horváth, P. Howarth, A.J. James, R. Knowles, A.J. Knox, N. Krug, D. Lefaudeux, M.J. Loza, R. Lutter, A. Manta, S. Masefield, A. Mazein, A. Meiser, R.J.M. Middelveld, M. Miralpeix, P. Montuschi, N. Mores, C.S. Murray, J. Musial, D. Myles, L. Pahus, I. Pandis, S. Pavlidis, P. Powell, G. Praticò, M. Puig N. Rao, J. Riley, A. Roberts, G. Roberts, A. Rowe, T. Sandström, W. Seibold, A. Selby, D.E. Shaw, R. Sigmund, F. Singer, P.J. Skipp, A.R. Sousa, P.J. Sterk, K. Sun, B. Thornton, W.M. van Aalderen, M. van Geest, J. Vestbo, N.H. Vissing, A.H. Wagener, S.S. Wagers, Z. Weiszhart, C.E. Wheelock, S.J. Wilson, Antonios Aliprantis, David Allen, Kjell Alving, P. Badorrek, David Balgoma, S. Ballereau, Clair Barber, Manohara Kanangana Batuwitage, A. Bautmans, A. Bedding, A.F. Behndig, Jorge Beleta, A. Berglind, A. Berton, Grazyna Bochenek, Armin Braun, D. Campagna, Leon Carayannopoulos, C. Casaulta, Romanas Chaleckis, B. Dahlén, imothy Davison, Jorge De Alba, Inge De Lepeleire, Tamara Dekker, Ingrid Delin, P. Dennison, Annemiek Dijkhuis, Paul Dodson, Aleksandra Draper, K. Dyson, Jessica Edwards, L. El Hadjam, Rosalia Emma, Magnus Ericsson, C. Faulenbach, Breda Flood, G. Galffy, Hector Gallart, D. Garissi, J. Gent, M. Gerhardsson de Verdier, D. Gibeon, Cristina Gomez, Kerry Gove, Neil Gozzard, E. Guillmant-Farry, E. Henriksson, Lorraine Hewitt, U. Hoda, Richard Hu, Sile Hu, X. Hu, E. Jeyasingham, K. Johnson, N. Jullian, Juliette Kamphuis, Erika J. Kennington, Dyson Kerry, G. Kerry, M. Klüglich, Hugo Knobel, Johan Kolmert, J.R. Konradsen, Maxim Kots, Kosmas Kretsos, L. Krueger, Scott Kuo, Maciej Kupczyk, Bart Lambrecht, A.-S. Lantz, Christopher Larminie, L.X. Larsson, P. Latzin, N. Lazarinis, N. Lemonnier, Saeeda Lone-Latif, L.A. Lowe, Alexander Manta, Lisa Marouzet, Jane Martin, Caroline Mathon, L. McEvoy, Sally Meah, A. Menzies-Gow, Leanne Metcalf, Maria Mikus, Philip Monk, Shama Naz, K. Nething, Ben Nicholas, U. Nihlén, Peter Nilsson, R. Niven, B. Nordlund, S. Nsubuga, Antonio Pacino, Susanna Palkonen, J. Pellet, Giorgio Pennazza, Anne Petrén, Sandy Pink, C. Pison, Anthony Postle, Malayka Rahman-Amin, Lara Ravanetti, Emma Ray, Stacey Reinke, Leanne Reynolds, K. Riemann, Martine Robberechts, J.P. Rocha, C. Rossios, Kirsty Russell, Michael Rutgers, G. Santini, Marco Santoninco, M. Saqi, Corinna Schoelch, S. Scott, N. Sehgal, Marcus Sjödin, Barbara Smids, Caroline Smith, Jessica Smith, Katherine M. Smith, P. Söderman, A. Sogbessan, F. Spycher, Doroteya Staykova, S. Stephan, J. Stokholm, K. Strandberg, M. Sunther, M. Szentkereszty, L. Tamasi, K. Tariq, John-Olof Thörngren, Jonathan Thorsen, S. Valente, Marianne van de Pol, C.M. van Drunen, Jonathan Van Eyll, Jenny Versnel, Anton Vink, C. von Garnier, A. Vyas, Frans Wald, Samantha Walker, Kristiane Wetzel, Coen Wiegman, Siân Williams, Xian Yang, Elizabeth Yeyasingham, W. Yu Amgen, W. Zetterquist, Z. Zolkipli, A.H. Zwinderman
Publikováno v:
Journal of Allergy and Clinical Immunology, 144(5), 1198-1213. Mosby Inc.
U-BIOPRED Study Group 2019, ' IL-17-high asthma with features of a psoriasis immunophenotype ', The Journal of allergy and clinical immunology . https://doi.org/10.1016/j.jaci.2019.03.027
Journal of allergy and clinical immunology, 144(5), 1198-1213. Mosby Inc.
Östling, J R, van Geest, M, U-BIOPRED Study Group, Schofield, J P R, Jevnikar, Z, Wilson, S, Ward, J, Lutter, R, Shaw, D E, Bakke, P S, Caruso, M, Dahlen, S-E, Fowler, S J, Horváth, I, Krug, N, Montuschi, P, Sanak, M, Sandström, T, Sun, K, Pandis, I, Auffray, C, Sousa, A R, Guo, Y, Adcock, I M, Howarth, P, Chung, K F, Bigler, J, Sterk, P J, Skipp, P J, Djukanović, R & Vaarala, O 2019, ' IL-17–high asthma with features of a psoriasis immunophenotype ', Journal of Allergy and Clinical Immunology, vol. 144, no. 5, pp. 1198-1213 . https://doi.org/10.1016/j.jaci.2019.03.027
U-BIOPRED Study Group 2019, ' IL-17-high asthma with features of a psoriasis immunophenotype ', The Journal of allergy and clinical immunology . https://doi.org/10.1016/j.jaci.2019.03.027
Journal of allergy and clinical immunology, 144(5), 1198-1213. Mosby Inc.
Östling, J R, van Geest, M, U-BIOPRED Study Group, Schofield, J P R, Jevnikar, Z, Wilson, S, Ward, J, Lutter, R, Shaw, D E, Bakke, P S, Caruso, M, Dahlen, S-E, Fowler, S J, Horváth, I, Krug, N, Montuschi, P, Sanak, M, Sandström, T, Sun, K, Pandis, I, Auffray, C, Sousa, A R, Guo, Y, Adcock, I M, Howarth, P, Chung, K F, Bigler, J, Sterk, P J, Skipp, P J, Djukanović, R & Vaarala, O 2019, ' IL-17–high asthma with features of a psoriasis immunophenotype ', Journal of Allergy and Clinical Immunology, vol. 144, no. 5, pp. 1198-1213 . https://doi.org/10.1016/j.jaci.2019.03.027
Background The role of IL-17 immunity is well established in patients with inflammatory diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in whom further study is required. Objective We sought to undertake a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924ef083d27395d6795993c461f0cec8
https://publica.fraunhofer.de/handle/publica/259279
https://publica.fraunhofer.de/handle/publica/259279
Autor:
Bart Hilvering, Timothy S.C. Hinks, Linda Stöger, Emanuele Marchi, Maryam Salimi, Rahul Shrimanker, Wei Liu, Wentao Chen, Jian Luo, Simei Go, Timothy Powell, Jennifer Cane, Samantha Thulborn, Ayako Kurioka, Tianqi Leng, Jamie Matthews, Clare Connolly, Catherine Borg, Mona Bafadhel, Christian B. Willberg, Adaikalavan Ramasamy, Ratko Djukanović, Graham Ogg, Ian D. Pavord, Paul Klenerman, Luzheng Xue
Publikováno v:
Mucosal Immunology. 12:581
Autor:
Stacey N, Reinke, Héctor, Gallart-Ayala, Cristina, Gómez, Antonio, Checa, Alexander, Fauland, Shama, Naz, Muhammad Anas, Kamleh, Ratko, Djukanović, Timothy S C, Hinks, Craig E, Wheelock
Publikováno v:
The European respiratory journal. 49(3)
In this study, we sought to determine whether asthma has a metabolic profile and whether this profile is related to disease severity.We characterised the serum from 22 healthy individuals and 54 asthmatics (12 mild, 20 moderate, 22 severe) using liqu