Zobrazeno 1 - 10
of 1 331
pro vyhledávání: '"Rational drug design"'
Autor:
Pengyun Li, Xiaotong Hu, Zhiya Fan, Shiyang Sun, Qijie Ran, Ting Wei, Pengli Wei, Qiyu Jiang, Jian Yan, Ning Yang, Changkai Jia, Tingting Yang, Yaqiu Mao, Xu Cai, Tingting Xu, Zhiyuan Zhao, Xiaohong Qian, Weijie Qin, Xiaomei Zhuang, Feng Fan, Junhai Xiao, Zhibing Zheng, Song Li
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-30 (2024)
Abstract Background Targeted protein degradation of neosubstrates plays a crucial role in hematological cancer treatment involving immunomodulatory imide drugs (IMiDs) therapy. Nevertheless, the persistence of inevitable drug resistance and hematolog
Externí odkaz:
https://doaj.org/article/53485170677d439b9bf56471960e9a2e
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3155-3162 (2024)
Cyclic peptides have emerged as versatile scaffolds in drug discovery due to their stability and specificity. Here, we present the cPEPmatch webserver (accessible at https://t38webservices.nat.tum.de/cpepmatch/), an easy-to-use interface for the rati
Externí odkaz:
https://doaj.org/article/1d878addc9ad430ab039684cfd68d57c
Autor:
Jessica Lombino, Rosario Vallone, Maura Cimino, Maria Rita Gulotta, Giada De Simone, Maria Agnese Morando, Raffaele Sabbatella, Simona Di Martino, Mario Fogazza, Federica Sarno, Claudia Coronnello, Maria De Rosa, Chiara Cipollina, Lucia Altucci, Ugo Perricone, Caterina Alfano
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Lysine demethylase enzymes (KDMs) are an emerging class of therapeutic targets, that catalyse the removal of methyl marks from histone lysine residues regulating chromatin structure and gene expression. KDM4A isoform plays an impo
Externí odkaz:
https://doaj.org/article/b96d859348f0461a9deca1a52950e217
Autor:
Milan Beljkas, Milos Petkovic, Ana Vuletic, Ana Djuric, Juan Francisco Santibanez, Tatjana Srdic-Rajic, Katarina Nikolic, Slavica Oljacic
Publikováno v:
Pharmaceutics, Vol 16, Iss 10, p 1250 (2024)
Background/Objectives: Alterations in the actin cytoskeleton correlates to tumor progression and affect critical cellular processes such as adhesion, migration and invasion. Rho-associated coiled-coil-containing protein kinases (ROCK1 and ROCK2), imp
Externí odkaz:
https://doaj.org/article/bd8868677c294249b17ff5df1ce6bb25
Autor:
P. A. Galenko-Yaroshevsky, I. Yu. Torshin, A. N. Gromov, O. A. Gromova, K. F. Suzdalev, R. A. Murashko, A. V. Zelenskaya, A. V. Zadorozhniy, T. R. Glechyan, G. V. Simavonyan, E. M.I. Muhammad
Publikováno v:
Фармакоэкономика, Vol 0, Iss 0 (2023)
Background. To plan effective and safe pharmacotherapy for inflammation and pain, it is important to evaluate the mechanisms and spectrum of action of nonsteroidal anti-inflammatory drugs (NSAIDs), including their effects on human proteome.Objective:
Externí odkaz:
https://doaj.org/article/45ff552e151d4f83b266b771527deff8
Publikováno v:
Arhiv za farmaciju, Vol 73, Iss 3, Pp 205-215 (2023)
Whereas nonselective nonsteroidal anti-inflammatory drugs, such as aspirin, ibuprofen and diclofenac, inhibit both cyclooxygenase-1 and cyclooxigenase-2 enzymes, selective inhibitors target cyclooxygenase-2, which is overexpressed in inflammation, bu
Externí odkaz:
https://doaj.org/article/2a8c6fc644604cddb9767a88fd31547b
Autor:
Yue Zhou, Todd B. Reynolds
Publikováno v:
Journal of Fungi, Vol 10, Iss 3, p 171 (2024)
Life-threatening systemic fungal infections occur in immunocompromised patients at an alarming rate. Current antifungal therapies face challenges like drug resistance and patient toxicity, emphasizing the need for new treatments. Membrane-bound enzym
Externí odkaz:
https://doaj.org/article/b263f084704e471dae03798a2f7f8c49
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