Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ratika Krishnamurty"'
Autor:
Eric T. Larson, Pratistha Ranjitkar, Stephen E. Leonard, Ethan A. Merritt, Dustin J. Maly, Ratika Krishnamurty, Edward J. Dale, Jennifer L. Brigham
Publikováno v:
Nature chemical biology
Protein kinases, key regulators of intracellular signal transduction, have emerged as an important class of drug targets. Chemical proteomic tools that facilitate the functional interrogation of protein kinase active sites are powerful reagents for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8461710d64350c39597701db7f6c9c6c
https://doi.org/10.1038/nchembio.1118
https://doi.org/10.1038/nchembio.1118
Autor:
Pratistha, Ranjitkar, B Gayani K, Perera, Danielle L, Swaney, Daniel L, Swaney, Sanjay B, Hari, Eric T, Larson, Ratika, Krishnamurty, Ethan A, Merritt, Judit, Villén, Dustin J, Maly
Publikováno v:
Journal of the American Chemical Society. 134:19017-19025
Protein kinases are key components of most mammalian signal transduction networks and are therapeutically relevant drug targets. Efforts to study protein kinase function would benefit from new technologies that are able to profile kinases in complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb94220a39697c94cb5225ae0a8d9c38
https://doi.org/10.1021/ja306035v
https://doi.org/10.1021/ja306035v
Autor:
Dustin J. Maly, Ratika Krishnamurty, Gabriel J. Brighty, Ames C. Register, Stephen E. Leonard
Publikováno v:
ACS Chemical Biology
Multidomain protein kinases, central controllers of signal transduction, use regulatory domains to modulate catalytic activity in a complex cellular environment. Additionally, these domains regulate noncatalytic functions, including cellular localiza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd6d33a973b265092cd36bae0cf3375
https://pubmed.ncbi.nlm.nih.gov/24946274
https://pubmed.ncbi.nlm.nih.gov/24946274
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(1)
Affinity reagents that target protein kinases are powerful tools for signal transduction research. Here, we describe a general set of kinase ligands based on a 5-aminoindazole scaffold. This scaffold can readily be derivatized with diverse binding el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0a2a27d6b9a3915c126a86793f38bc
https://pubmed.ncbi.nlm.nih.gov/21078554
https://pubmed.ncbi.nlm.nih.gov/21078554
Autor:
Dustin J. Maly, Ratika Krishnamurty
Publikováno v:
ACS chemical biology. 5(1)
Protein kinases have emerged as one of the most frequently targeted families of proteins in drug discovery. While the development of small-molecule inhibitors that have the potency and selectivity necessary to be effective cancer drugs is still a for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf09fc1e6cad0c5fb4b2affe3bea00d
https://pubmed.ncbi.nlm.nih.gov/20044834
https://pubmed.ncbi.nlm.nih.gov/20044834
Autor:
Dustin J. Maly, Ratika Krishnamurty
Publikováno v:
Combinatorial chemistryhigh throughput screening. 10(8)
The clinical success of the Bcr-Abl tyrosine kinase inhibitor Gleevec((R)) and the recent clinical approval of a number of small molecule drugs that target protein kinases have intensified the search for novel protein kinase inhibitors. Since most sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a52e2077fe9ff711322eb57f5eac8f7
https://pubmed.ncbi.nlm.nih.gov/18045078
https://pubmed.ncbi.nlm.nih.gov/18045078
Autor:
Danielle L. Swaney, Pratistha Ranjitkar, Judit Villén, Eric T. Larson, Sanjay B. Hari, B. Gayani K. Perera, Dustin J. Maly, Ethan A. Merritt, Ratika Krishnamurty
Publikováno v:
Journal of the American Chemical Society. 135:948-948
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa6965cf43a99a0d8929719335a2e2da
https://doi.org/10.1021/ja3120967
https://doi.org/10.1021/ja3120967