Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rati Tripathi"'
Publikováno v:
Folia Medica, Vol 63, Iss 1, Pp 7-14 (2021)
Cancer refers to the group of diseases characterized by uncontrolled growth of abnormal cells. It spreads throughout the body which makes this disease one of the huge global threats to mankind. Intensive research over the years has established deregu
Externí odkaz:
https://doaj.org/article/d1e1410bb793460e84e4097a0c625e48
Autor:
Stephen Smith, Rati Tripathi, Charnise Goodings, Susan Cleveland, Elizabeth Mathias, J Andrew Hardaway, Natalina Elliott, Yajun Yi, Xi Chen, James Downing, Charles Mullighan, Deborah A Swing, Lino Tessarollo, Liqi Li, Paul Love, Nancy A Jenkins, Neal G Copeland, Mary Ann Thompson, Yang Du, Utpal P Davé
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85883 (2014)
The LMO2 oncogene is deregulated in the majority of human T-cell leukemia cases and in most gene therapy-induced T-cell leukemias. We made transgenic mice with enforced expression of Lmo2 in T-cells by the CD2 promoter/enhancer. These transgenic mice
Externí odkaz:
https://doaj.org/article/21c934cd035a404580d328b1c317cbed
Autor:
Utpal P Davé, Keiko Akagi, Rati Tripathi, Susan M Cleveland, Mary A Thompson, Ming Yi, Robert Stephens, James R Downing, Nancy A Jenkins, Neal G Copeland
Publikováno v:
PLoS Genetics, Vol 5, Iss 5, p e1000491 (2009)
Five X-linked severe combined immunodeficiency patients (SCID-X1) successfully treated with autologous bone marrow stem cells infected ex vivo with an IL2RG-containing retrovirus subsequently developed T-cell leukemia and four contained insertional m
Externí odkaz:
https://doaj.org/article/a5b7392dd5524f7c8d5a9bf7304d5f68
Autor:
Vincent A. Miller, Kai Wang, Phil Stephens, Jonathan M. Irish, Derya Unutmaz, Allison R. Greenplate, Norma Alonzo Palma, Siraj M. Ali, Rati Tripathi, Yu Shyr, Yan Guo, Utpal P. Davé, Xueyan Chen, Lina Kozhaya, Nishitha Reddy
Publikováno v:
JCO Precision Oncology. :1-16
Purpose The promise of precision oncology is that identification of genomic alterations will direct the rational use of molecularly targeted therapy. This approach is particularly applicable to neoplasms that are resistant to standard cytotoxic chemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05af9a5cba7f13206f95d8851536081d
https://doi.org/10.1200/po.17.00019
https://doi.org/10.1200/po.17.00019
Autor:
Xi Chen, Justin H. Layer, Susan M. Cleveland, Yan Guo, Rizwan Hamid, Rati Tripathi, Natalina Elliott, Elizabeth Mathias, Utpal P. Davé, Yu Shyr, Charnise Goodings, Elizabeth Smith, Yang Du
Publikováno v:
Stem Cells. 33:2628-2641
Hhex encodes a homeodomain transcription factor that is widely expressed in hematopoietic stem and progenitor cell populations. Its enforced expression induces T-cell leukemia and we have implicated it as an important oncogene in early T-cell precurs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc2964b51e5be0d42aea441581030bc
https://doi.org/10.1002/stem.2049
https://doi.org/10.1002/stem.2049
Autor:
Natalina Elliott, Utpal P. Davé, Yu Shyr, Rati Tripathi, Yan Guo, Charnise Goodings, Susan M. Cleveland
Publikováno v:
Leukemia Research. 39:100-109
LIM domain Only-2 (LMO2) overexpression in T cells induces leukemia but the molecular mechanism remains to be elucidated. In hematopoietic stem and progenitor cells, Lmo2 is part of a protein complex comprised of class II basic helix loop helix prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0fe3272e3f1d48854f6b519d4c71e1
https://doi.org/10.1016/j.leukres.2014.11.016
https://doi.org/10.1016/j.leukres.2014.11.016
Autor:
Xi Chen, Charles G. Mullighan, Elizabeth Mathias, Charnise Goodings, Natalina Elliott, Susan M. Cleveland, Paul E. Love, James R. Downing, LiQi Li, Utpal P. Davé, Dunfa Peng, Wael El-Rifai, Dajun Yi, Rati Tripathi, Stephen B. Smith
Publikováno v:
Stem Cells. 31:882-894
LIM domain only 2 (Lmo2) is frequently deregulated in sporadic and gene therapy-induced acute T-cell lymphoblastic leukemia (T-ALL) where its overexpression is an important initiating mutational event. In transgenic and retroviral mouse models, Lmo2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b54e0af121a27864084742dee4163f
https://doi.org/10.1002/stem.1345
https://doi.org/10.1002/stem.1345
Autor:
LiQi Li, Nancy A. Jenkins, Rati Tripathi, Susan M. Cleveland, Deborah A. Swing, Utpal P. Davé, Elizabeth Mathias, Lino Tessarollo, Natalina Elliott, Yajun Yi, Stephen B. Smith, Neal G. Copeland, Mary Ann Thompson, Charles G. Mullighan, Paul E. Love, J. Andrew Hardaway, Charnise Goodings, Xi Chen, James R. Downing, Yang Du
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85883 (2014)
PLoS ONE
PLoS ONE
The LMO2 oncogene is deregulated in the majority of human T-cell leukemia cases and in most gene therapy-induced T-cell leukemias. We made transgenic mice with enforced expression of Lmo2 in T-cells by the CD2 promoter/enhancer. These transgenic mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0c591193e989654379d46add9c59cc
http://europepmc.org/articles/PMC3897537?pdf=render
http://europepmc.org/articles/PMC3897537?pdf=render
Autor:
Robert L. Stephens, Utpal P. Davé, Susan M. Cleveland, Nancy A. Jenkins, Keiko Akagi, Ming Yi, Neal G. Copeland, Rati Tripathi, James R. Downing, Mary Ann Thompson
Publikováno v:
PLoS Genetics, Vol 5, Iss 5, p e1000491 (2009)
PLoS Genetics
PLoS Genetics
Five X-linked severe combined immunodeficiency patients (SCID-X1) successfully treated with autologous bone marrow stem cells infected ex vivo with an IL2RG-containing retrovirus subsequently developed T-cell leukemia and four contained insertional m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189cec1eb9e802e93f490e53a84521a0
http://europepmc.org/articles/PMC2679194?pdf=render
http://europepmc.org/articles/PMC2679194?pdf=render
Autor:
Nishitha Reddy, Kai Wang, Siraj M. Ali, Norma Alonzo Palma, Utpal P. Davé, Derya Unutmaz, Jonathan M. Irish, Phil Stephens, Vincent A. Miller, Rati Tripathi, Allison R. Greenplate
Publikováno v:
Blood. 124:1672-1672
Background: T-cell leukemias and lymphomas (TL&Ls) are rare when compared with other hematologic malignancies, and pose a challenge for clinical management. TL&Ls are characteristically resistant to chemotherapeutic regimens used to treat other hemat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0154e7024475348cf537462da507ee68
https://doi.org/10.1182/blood.v124.21.1672.1672
https://doi.org/10.1182/blood.v124.21.1672.1672