PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer.

Autor: Salvi A; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA., Young AN; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA., Huntsman AC; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA., Pergande MR; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, 60607, USA., Korkmaz MA; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, 60607, USA., Rathnayake RA; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, 60607, USA., Mize BK; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA., Kinghorn AD; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA., Zhang X; Department of Biomedical Informatics, The Ohio State University, Columbus, OH, 43210, USA., Ratia K; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA., Schirle M; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Thomas JR; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Brittain SM; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Shelton C; Novartis Institutes for BioMedical Research, 181 Massachusetts Avenue, Cambridge, MA, 02139, USA., Aldrich LN; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, 60607, USA., Cologna SM; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, 60607, USA., Fuchs JR; Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH, 43210, USA., Burdette JE; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, 60607, USA. joannab@uic.edu.

Publikováno v: Cell death & disease [Cell Death Dis] 2022 Jan 10; Vol. 13 (1), pp. 45. Date of Electronic Publication: 2022 Jan 10.