A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart

Autor: Iyer, Lavanya M, Nagarajan, Sankari, Woelfer, Monique, Schoger, Eric, Khadjeh, Sara, Zafiriou, Maria Patapia, Kari, Vijayalakshmi, Herting, Jonas, Pang, Sze Ting, Weber, Tobias, Rathjens, Franziska S, Fischer, Thomas H, Toischer, Karl, Hasenfuss, Gerd, Noack, Claudia, Johnsen, Steven A, Zelarayán, Laura C

Publikováno v: Nucleic Acids Research
Iyer, L M, Nagarajan, S, Woelfer, M, Schoger, E, Khadjeh, S, Zafiriou, M P, Kari, V, Herting, J, Pang, S T, Weber, T, Rathjens, F S, Fischer, T H, Toischer, K, Hasenfuss, G, Noack, C, Johnsen, S A & Zelarayán, L C 2018, ' A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart ', Nucleic acids research, vol. 46, no. 6, pp. 2850-2867 . https://doi.org/10.1093/nar/gky049

Chromatin remodelling precedes transcriptional and structural changes in heart failure. A body of work suggests roles for the developmental Wnt signalling pathway in cardiac remodelling. Hitherto, there is no evidence supporting a direct role of Wnt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::60753350bf19cebbb1ba015ae696e51b
http://europepmc.org/articles/PMC5887416