Kindlin Is Mechanosensitive: Force-Induced Conformational Switch Mediates Cross-Talk among Integrins

Autor: Jahed, Zeinab, Haydari, Zainab, Rathish, Akshay, Mofrad, Mohammad RK

Publikováno v: Biophysical journal, vol 116, iss 6

Mechanical stresses directly regulate the function of several proteins of the integrin-mediated focal adhesion complex as they experience intra- and extracellular forces. Kindlin is a largely overlooked member of the focal adhesion complex whose role

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https://escholarship.org/uc/item/1p33689g

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Role of KASH domain lengths in the regulation of LINC complexes.

Autor: Jahed Z; Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720., Hao H; Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616., Thakkar V; Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720., Vu UT; Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720., Valdez VA; Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616., Rathish A; Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720., Tolentino C; Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720., Kim SCJ; Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720., Fadavi D; Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720., Starr DA; Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616., Mofrad MRK; Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, Berkeley, CA 94720.; Molecular Biophysics and Integrative Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.

Publikováno v: Molecular biology of the cell [Mol Biol Cell] 2019 Jul 22; Vol. 30 (16), pp. 2076-2086. Date of Electronic Publication: 2019 Apr 17.