Increased prevalence of potential right-to-left shunting in children with sickle cell anaemia and stroke

Autor: Claudio Ramaciotti, Rathi V. Iyer, Julie Kanter, Michael M. Dowling, Fenella J. Kirkham, William Owen, Melissa Rhodes, Charles T. Quinn, Ifeyinwa Osunkwo, Sharada A. Sarnaik, C. Johnson, Linda S. Hynan, Nomazulu Dlamini, Julie A. Panepinto, Janet L. Kwiatkowski, Lynne Neumayr, Patricia Plumb, John J. Strouse, Baba Inusa

Publikováno v: British Journal of Haematology. 176:300-308

Paradoxical' embolization via intracardiac or intrapulmonary right-to-left shunts (RLS) is an established cause of stroke. Hypercoagulable states and increased right heart pressure, which both occur in sickle cell anaemia (SCA), predispose to paradox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbef938003ab7eb86b0f6486698753bc
https://doi.org/10.1111/bjh.14391

Protein-Losing Enteropathy due to Intestinal and Colonic Involvement With Langerhans Cell Histiocytosis and Review of the Literature

Autor: Michael J. Nowicki, Rathi V. Iyer, Matthew A Miller, Phyllis R. Bishop

Publikováno v: Clinical Pediatrics. 53:89-94

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25bacd950e3a740c8fa6700c07f8d55f
https://doi.org/10.1177/0009922813492884

A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A

Autor: Brigit Brand, Alessandro Gringeri, Paul Giangrande, James J. Goedert, Michael Recht, Olga Katsarou, Ana Rosa Cid-Haro, Patrick F. Fogarty, Steven M. Wolinsky, Evelien P. Mauser-Bunschoten, Judith Lin, Kate Talks, Javier Martinez-Picado, Amy D. Shapiro, Amalio Telenti, Christine L. Kempton, Lucy Dorrell, David Goldstein, Jérôme Lane, Jerry S. Powell, Sara Colombo, Judith Dalmau, Jeremy J. Martinson, Johannes Oldenburg, Shehnaz K. Hussain, Barton F. Haynes, Michael Makris, Dimitrios A. Tsakiris, Amanda Stemke, Anne T. Neff, Stephen Moore, Shinichi Oka, Philip Kuriakose, Rathi V. Iyer, Jonathan T. Wilde, Peter William Collins, Maria Teresa Alvarez-Roman, Andrew J. McMichael, Rafael Parra, Françoise Boehlen, Paul J. McLaren, Deborah L Brown, Marilyn J. Manco-Johnson, Thynn Thynn Yee, Kimo C. Stine, Bonaventura Clotet, Kimberly Pelak, Jay H. Bream, Kristiina Peter-Salonen, Paula H B Bolton-Maggs, Elaine Y. Chiang, Lisa P. Jacobson, Mary Carrington, Lara Oyesiku, Anne Angelillo-Scherrer, Jacques Fellay, Kevin V. Shianna

Publikováno v: Lane, Jérôme; McLaren, Paul J.; Dorrell, Lucy; Shianna, Kevin V.; Stemke, Amanda; Pelak, Kimberly; Moore, Stephen; Oldenburg, Johannes; Boehlen, Francoise; Alvarez-Roman, Maria Teresa; Angelillo-Scherrer, Anne; Bolton-Maggs, Paula H. B.; Brand, Brigit; Brown, Deborah; Chiang, Elaine; Cid-Haro, Ana Rosa; Clotet, Bonaventura; Collins, Peter; Colombo, Sara; Dalmau, Judith; ... (2013). A genome-wide association study of resistance to HIV infection in highly exposed uninfected individuals with hemophilia A. Human molecular genetics, 22(9), pp. 1903-1910. Oxford University Press 10.1093/hmg/ddt033
Human Molecular Genetics, Vol. 22, No 9 (2013) pp. 1903-1910
Human molecular genetics
Human Molecular Genetics, vol. 22, no. 9, pp. 1903-1910

Human genetic variation contributes to differences in susceptibility to HIV-1 infection. To search for novel host resistance factors, we performed a genome-wide association study (GWAS) in hemophilia patients highly exposed to potentially contaminate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1c24750bfdac52d92b3d5e567a3f03
https://doi.org/10.1093/hmg/ddt033

Associated risk factors for silent cerebral infarcts in sickle cell anemia: low baseline hemoglobin, sex, and relative high systolic blood pressure

Autor: Corina E. Gonzalez, Gerald M. Woods, Karen Kalinyak, Julie A. Panepinto, Hernan Sabio, Melissa Rhodes, Sharada A. Sarnaik, Allison A. King, Françoise Bernaudin, Gladstone Airewele, Michael J. Noetzel, James F. Casella, Rupa Redding-Lallinger, Janet K. Kwiatkowski, Beng Fuh, Mae O. Gordon, Charles T. Quinn, J. Phillip Miller, Mark Rodeghier, Mark E. Heiny, Fenella J. Kirkham, Suzanne Saccente, Baba Inusa, Jason Fixler, Caterina P. Minniti, Rebecca Ichord, Alexis A. Thompson, Paul Telfer, Thomas H. Howard, John J. Strouse, Michael R. DeBaun, Melanie Kirby-Allen, Rathi V. Iyer

Publikováno v: Blood. 119:3684-3690

The most common form of neurologic injury in sickle cell anemia (SCA) is silent cerebral infarction (SCI). In the Silent Cerebral Infarct Multi-Center Clinical Trial, we sought to identify risk factors associated with SCI. In this cross-sectional stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f52c8e472191985e41daafacbc681f
https://doi.org/10.1182/blood-2011-05-349621

Stroke with transfusions changing to hydroxyurea (SWiTCH): A phase III randomized clinical trial for treatment of children with sickle cell anemia, stroke, and iron overload

Autor: Ronald W. Helms, Rathi V. Iyer, Zora R. Rogers, Scott T. Miller, Russell E. Ware, Nicole A. Mortier, Myron A. Waclawiw, Lee Hilliard, William H. Schultz, Nancy A. Yovetich, J. Paul Scott, Ofelia A. Alvarez

Publikováno v: Pediatric Blood & Cancer. 57:1011-1017

Background Stroke occurs in 5–10% of children with sickle cell anemia (SCA) and has a high (>50%) risk of recurrence without therapy. Chronic monthly erythrocyte transfusions effectively prevent recurrent stroke, but their long term use is limited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::182278130d86d1c77d2dadc715e12687
https://doi.org/10.1002/pbc.23145