Proliferation and Self-Renewal Are Differentially Sensitive to NRASG12V Oncogene Levels in an Acute Myeloid Leukemia Cell Line.

Autor: Kurata M; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Antony ML; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota., Noble-Orcutt KE; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota., Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Lee Y; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota.; Bioinformatics and Computational Biology Graduate Program, University of Minnesota, Minneapolis, Minnesota., Furuno H; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Ishibashi S; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Ikeda M; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Yamamoto K; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Kitagawa M; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan., Largaespada DA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Pediatrics, Division of Hematology and Oncology, University of Minnesota, Minneapolis, Minnesota.; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota., Sachs Z; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, Minnesota.; Bioinformatics and Computational Biology Graduate Program, University of Minnesota, Minneapolis, Minnesota.

Publikováno v: Molecular cancer research : MCR [Mol Cancer Res] 2022 Nov 03; Vol. 20 (11), pp. 1646-1658.

R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers.

Autor: Conboy CB; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Vélez-Reyes GL; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Abrahante JE; University of Minnesota Informatics Institute, Minneapolis, Minnesota, USA., Temiz NA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA., Burns MB; Biochemistry, Molecular Biology and Biophysics Department, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA., Harris RS; Biochemistry, Molecular Biology and Biophysics Department, University of Minnesota, Minneapolis, Minnesota, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA.; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota, USA., Starr TK; Department of Obstetrics, Gynecology and Women's Health and University of Minnesota, Minneapolis, Minnesota, USA., Largaespada DA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.

Publikováno v: DNA and cell biology [DNA Cell Biol] 2021 Jan; Vol. 40 (1), pp. 70-79. Date of Electronic Publication: 2020 Dec 15.

PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma.

Autor: Smeester BA; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America., Slipek NJ; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America., Pomeroy EJ; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America., Laoharawee K; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America., Osum SH; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America., Larsson AT; Masonic Cancer Center, University of Minnesota, United States of America., Williams KB; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America., Stratton N; Department of Pediatrics, University of Minnesota, United States of America., Yamamoto K; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America., Peterson JJ; Department of Pediatrics, University of Minnesota, United States of America., Rathe SK; Department of Pediatrics, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America., Mills LJ; Department of Pediatrics, University of Minnesota, United States of America; Childhood Cancer Genomics Group, University of Minnesota, United States of America., Hudson WA; Department of Pediatrics, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America., Crosby MR; Department of Pediatrics, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America., Wang M; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America., Rahrmann EP; Cancer Research UK Cambridge Institute, University of Cambridge, United Kingdom of Great Britain and Northern Ireland., Moriarity BS; Department of Pediatrics, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America. Electronic address: mori0164@umn.edu., Largaespada DA; Department of Pediatrics, University of Minnesota, United States of America; Department of Genetics, Cell Biology and Development, University of Minnesota, United States of America; Center for Genome Engineering, University of Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, United States of America. Electronic address: larga002@umn.edu.

Publikováno v: Bone [Bone] 2020 Jul; Vol. 136, pp. 115353. Date of Electronic Publication: 2020 Apr 03.

Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma.

Autor: Rahrmann EP; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota. eric.rahrmann@cruk.cam.ac.uk.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Wolf NK; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota., Otto GM; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Heltemes-Harris L; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Lab Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.; Department of Laboratory Medicine and Pathology, Division of Hematopathology, University of Minnesota, Minneapolis, Minnesota., Ramsey LB; Department of Laboratory Medicine and Pathology, Division of Hematopathology, University of Minnesota, Minneapolis, Minnesota., Shu J; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., LaRue RS; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Linden MA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Center for Immunology, University of Minnesota, Minneapolis, Minnesota., Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Starr TK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Ob-Gyn and Women's Health, University of Minnesota, Minneapolis, Minnesota., Farrar MA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Lab Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.; Department of Laboratory Medicine and Pathology, Division of Hematopathology, University of Minnesota, Minneapolis, Minnesota., Moriarity BS; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota., Largaespada DA; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota.; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.

Publikováno v: Molecular cancer research : MCR [Mol Cancer Res] 2019 Feb; Vol. 17 (2), pp. 567-582. Date of Electronic Publication: 2018 Oct 24.

Comparative Transcriptome Analysis Quantifies Immune Cell Transcript Levels, Metastatic Progression, and Survival in Osteosarcoma.

Autor: Scott MC; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Animal Cancer Care and Research Program, University of Minnesota, St. Paul, Minnesota.; Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota., Temiz NA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota., Sarver AE; Department of Surgery, University of Minnesota School of Medicine, Minneapolis, Minnesota.; Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, Minnesota., LaRue RS; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Medicine, University of Minnesota School of Medicine, Minneapolis, Minnesota., Rathe SK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Varshney J; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Wolf NK; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Genetics, Cell Biology and Development, University of Minnesota School of Medicine, Minneapolis, Minnesota., Moriarity BS; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Brain Tumor Program, University of Minnesota, Minneapolis, Minnesota.; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota.; Department of Veterinary Population Medicine, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota., O'Brien TD; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Animal Cancer Care and Research Program, University of Minnesota, St. Paul, Minnesota.; Department of Veterinary Population Medicine, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota.; Stem Cell Institute University of Minnesota, Minneapolis, Minnesota., Spector LG; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, Minnesota., Largaespada DA; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, Minnesota.; Department of Genetics, Cell Biology and Development, University of Minnesota School of Medicine, Minneapolis, Minnesota.; Brain Tumor Program, University of Minnesota, Minneapolis, Minnesota.; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota., Modiano JF; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Animal Cancer Care and Research Program, University of Minnesota, St. Paul, Minnesota.; Department of Veterinary Clinical Sciences, University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota.; Stem Cell Institute University of Minnesota, Minneapolis, Minnesota.; Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota.; Center for Immunology, University of Minnesota, Minneapolis, Minnesota., Subramanian S; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.; Department of Surgery, University of Minnesota School of Medicine, Minneapolis, Minnesota., Sarver AL; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. sarver@umn.edu.; Institute for Health Informatics, University of Minnesota, Minneapolis, Minnesota.

Publikováno v: Cancer research [Cancer Res] 2018 Jan 15; Vol. 78 (2), pp. 326-337. Date of Electronic Publication: 2017 Oct 24.