Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization

Autor: Mats Bemark, Helena Hazanov, Anneli Strömberg, Rathan Komban, Joel Holmqvist, Sofia Köster, Johan Mattsson, Per Sikora, Ramit Mehr, Nils Y. Lycke

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)

The presence of long-lived memory IgA-producing B cells in the intestine has been difficult to document. Here the authors show that these cells can be induced by oral but not systemic immunization in mice, and characterize unique features that distin

Externí odkaz: https://doaj.org/article/3f378a82abe14213ae3c6b066e47eba1

Activated Peyer′s patch B cells sample antigen directly from M cells in the subepithelial dome

Autor: Neil A. Mabbott, Rathan Komban, Ulf Yrlid, Anneli Strömberg, Ziv Shulman, Mats Bemark, Jakob Cervin, Nils Lycke, Cristina Lebrero-Fernández, Adi Biram

Publikováno v: Komban, R J, Stromberg, A, Biram, A, Cervin, J, Lebrero-Fernandez, C, Mabbott, N, Yrlid, U, Shulman, Z, Bemark, M & Lycke, N 2019, ' Activated Peyer's patch B cells sample antigen directly from M cells in the subepithelial dome ', Nature Communications, vol. 10, 2423 (2019), pp. 1-15 . https://doi.org/10.1038/s41467-019-10144-w
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

The germinal center (GC) reaction in Peyer′s patches (PP) requires continuous access to antigens, but how this is achieved is not known. Here we show that activated antigen-specific CCR6+CCR1+GL7− B cells make close contact with M cells in the su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ffcab7519721c9738d0c0598037d3f