Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ratcliffe, Giles S."'
Autor:
Bryans, Justin S. a, *, Horwell, David C. a, Ratcliffe, Giles S. a, Receveur, Jean-Marie a, Rubin, J.Ronald b
Publikováno v:
In Bioorganic & Medicinal Chemistry 1999 7(5):715-721
Autor:
J. Ronald Rubin, Russell A. Lewthwaite, David C. Horwell, Martyn Clive Pritchard, Ratcliffe Giles S
Publikováno v:
Tetrahedron. 54:4591-4606
A series of piperazinone ring systems have been synthesised as a means of evaluating the effect of conformational restriction on high affinity non-peptide NK1, NK3 and CCK-B receptor ligands. The synthesis of the targeted heterocycles is described al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b2910063300992b6317effe0283658c
https://doi.org/10.1016/s0040-4020(98)00092-1
https://doi.org/10.1016/s0040-4020(98)00092-1
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:33-42
The design and synthesis of conformationally constrained, nonpeptide templates (1,1,6-trisubstituted indanes) which allow the incorporation of two adjacent amino acid side chains, plus a third binding group in an orientation similar to that found in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3901e1d032a6de2b591aa9dfb2f445ad
https://doi.org/10.1016/0968-0896(95)00169-7
https://doi.org/10.1016/0968-0896(95)00169-7
Autor:
Ratcliffe Giles S, David C. Horwell, William Howson, Sophie Williams, Michael Higginbottom, Dorica Naylor
Publikováno v:
Journal of Medicinal Chemistry. 38:4454-4462
The ability of three-dimensional quantitative structure-activity relationships (QSARs) derived from classical QSAR descriptors and similarity indices to rationalize the activity of 28 N-terminus fragments of tachykinin NK1 receptor antagonists was ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d030cd4920773315fe8fd9f7bbd6c24
https://doi.org/10.1021/jm00022a010
https://doi.org/10.1021/jm00022a010
Autor:
David C. Rees, William Howson, Ratcliffe Giles S, Henriëtte M. G. Willems, David Christopher Horwell, William P. Nolan
Publikováno v:
Tetrahedron. 51:203-216
The design and synthesis of conformationally restrained, non-peptide templates (1,6-disubstituted indanes) which allow the incorporation of two adjacent amino acid side-chains in an orientation similar to that found in alpha-helices is reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ae49f6963cd898e69d10157b13256af
https://doi.org/10.1016/0040-4020(94)00887-z
https://doi.org/10.1016/0040-4020(94)00887-z
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2825-2830
The design and synthesis of conformationally constrained, non-peptide templates (trisubstituted indanes) which allow the incorporation of two adjacent amino acid side-chains plus a third binding group in an orientation similar to that found in alpha-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::817714b5836a81829827a66347f6b56c
https://doi.org/10.1016/s0960-894x(01)80821-0
https://doi.org/10.1016/s0960-894x(01)80821-0
Publikováno v:
The Journal of Organic Chemistry. 59:4418-4423
Methyl 1,3,4,5-tetrahydro-4-[[(phenylmethoxy)carbonyl]amino]-1H-cyclo- oct[cd]indole-4-carboxylate, methyl 3,4,5,6-tetrahydro-6-methylene-4- [[(phenylmethoxy)carbonyl]amino]-1H-cyclohept[cd]indole4-carboxylate, and methyl 3,4-dihydro-6-methyl-4-[[(ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::321d15673adcc0ba7588d33bab7dcca9
https://doi.org/10.1021/jo00095a015
https://doi.org/10.1021/jo00095a015
Autor:
J.M. Eden, J. Hodgson, P. Boden, Ratcliffe Giles S, Alexander T. McKnight, David Christopher Horwell, Martyn Clive Pritchard, Jenny Raphy, N. Suman-Chauhan, John Hughes, Kenneth G. Meecham, Geoffrey N. Woodruff, William Howson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1679-1684
Boc(S)Phe(S)PheNH2 (1c) was identified from the biological screening of an in-house dipeptide chemical library as a micromolar NK3 receptor selective ligand (IC50=1150nM). This lead structure has subsequently been developed into a series of potent an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6e6c10a1dbc147fae4d032f7efc0b4b
https://doi.org/10.1016/s0960-894x(00)80360-1
https://doi.org/10.1016/s0960-894x(00)80360-1
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:799-802
A physico-chemical information rich library of 256 N-protected dipeptides is described. This library has been constructed using a factorial design in the principal properties of the amino acids. These compounds represent a data set of diverse physica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19e50da6aed587824b077c40242f7402
https://doi.org/10.1016/s0960-894x(00)80669-1
https://doi.org/10.1016/s0960-894x(00)80669-1
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a100b1831c6d784896761e974ee2396
https://doi.org/10.1002/chin.199317136
https://doi.org/10.1002/chin.199317136