Zobrazeno 1 - 10
of 2 660
pro vyhledávání: '"Rat liver microsomes"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1053 (2024)
Kokusaginine is a bioactive ingredient extracted from Ruta graveolens L., which has a range of biological activities. Its pharmacokinetic (PK) properties are particularly important for clinical applications; however, they have not been fully elucidat
Externí odkaz:
https://doaj.org/article/cbf9a69f33f8470d9e73f8f3bc9a01e5
Akademický článek
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Autor:
Hong Y, Dai DP, Cai JP, Wang SH, Wang YR, Zhao FL, Zhou S, Zhou Q, Geng PW, Zhou YF, Xu X, Shi JH, Luo QF
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 16, Pp 1779-1789 (2022)
Yun Hong,1,* Da-Peng Dai,2,* Jian-Ping Cai,2 Shuang-Hu Wang,3 Yi-Ran Wang,1,4 Fang-Ling Zhao,2,4 Shan Zhou,2 Quan Zhou,3 Pei-Wu Geng,3 Yun-Fang Zhou,3 Xue Xu,1 Ji-Hua Shi,1 Qing-Feng Luo1 1Department of Gastroenterology, Beijing Hospital, Nat
Externí odkaz:
https://doaj.org/article/e8e3edf720264c26999b6d60ba36260c
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The cytochrome P450 (CYP) enzymes play a pivotal role in drug metabolism. LC-MS/MS-based targeting technology has been applied to the analysis of CYP enzymes, promoting drug development and drug-drug interaction studies. Rat is one of the most common
Externí odkaz:
https://doaj.org/article/847849778d5c49848973092fff1a3f17
Autor:
L. M. Polyakov, R. A. Knyazev, N. V. Trifonova, M. V. Kotova, E. I. Solovyova, A. V. Ryabchenko
Publikováno v:
Атеросклероз, Vol 16, Iss 4, Pp 13-17 (2020)
This work presents the characteristics of the catalytic activity of hydroxylation of benzo[a] pyrene (B[a]P) in rat liver microsomes using plasma lipoproteins (LP) (VLDL, LDL, HDL) as transport forms of B[a]P. The aim of the study was: to study the e
Externí odkaz:
https://doaj.org/article/f6f12d58f58d4af985ac868145b2ba49
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 14, Pp 1909-1919 (2020)
Yunfang Zhou,1,* Ailian Hua,2,* Quan Zhou,1 Peiwu Geng,1 Feifei Chen,1 Lianhe Yan,1 Shuanghu Wang,1 Congcong Wen3 1The Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People’s Hospital of Lishui, Li
Externí odkaz:
https://doaj.org/article/b030ee7882354b5e8940ef309d8b6c8f
Autor:
Jia Chong, Hao Chen, Dapeng Dai, Shuanghu Wang, Quan Zhou, Junpeng Liu, You Lü, Hualan Wu, Minghui Du, Feifei Chen, Hui Jiang, Yunfang Zhou, Jiefu Yang
Publikováno v:
Pharmaceutical Biology, Vol 58, Iss 1, Pp 630-635 (2020)
Context Rivaroxaban and ticagrelor are two common drugs for the treatment of atrial fibrillation and acute coronary syndrome. However, the drug–drug interaction between them is still unknown. Objective To investigate the effects of ticagrelor on th
Externí odkaz:
https://doaj.org/article/6e8c3613c83c425c847cb050c63cc770
Publikováno v:
Molecules, Vol 27, Iss 7, p 2238 (2022)
The role of individual cytochrome P450 (CYPs) responsible for the drug metabolism can be determined through their chemical inhibition. During the pandemic, dexamethasone and remdesivir with omeprazole were used for the treatment of COVID-19, while Ib
Externí odkaz:
https://doaj.org/article/aed59946d5ba4b38ae4fea6672d031b2