Linear viscoelastic properties of the vertex model for epithelial tissues.

Autor: Sijie Tong, Navreeta K Singh, Rastko Sknepnek, Andrej Košmrlj

Publikováno v: PLoS Computational Biology, Vol 18, Iss 5, p e1010135 (2022)

Epithelial tissues act as barriers and, therefore, must repair themselves, respond to environmental changes and grow without compromising their integrity. Consequently, they exhibit complex viscoelastic rheological behavior where constituent cells ac

Externí odkaz: https://doaj.org/article/97aac8108d0a4c58aa692fbc0207a9ac

Linear viscoelastic response of the vertex model with internal and external dissipation: Normal modes analysis

Autor: Sijie Tong, Rastko Sknepnek, Andrej Košmrlj

Publikováno v: Physical Review Research, Vol 5, Iss 1, p 013143 (2023)

We use the normal mode formalism to study the shear rheology of the vertex model for epithelial tissue mechanics in the overdamped linear response regime. We consider systems with external (e.g., cell-substrate) and internal (e.g., cell-cell) dissipa

Externí odkaz: https://doaj.org/article/64317462a3884fea8e25b31b4c3e5227

Active Vertex Model for cell-resolution description of epithelial tissue mechanics.

Autor: Daniel L Barton, Silke Henkes, Cornelis J Weijer, Rastko Sknepnek

Publikováno v: PLoS Computational Biology, Vol 13, Iss 6, p e1005569 (2017)

We introduce an Active Vertex Model (AVM) for cell-resolution studies of the mechanics of confluent epithelial tissues consisting of tens of thousands of cells, with a level of detail inaccessible to similar methods. The AVM combines the Vertex Model

Externí odkaz: https://doaj.org/article/2707680d8eaa434b9b84a5ff8842d2ea

Dense active matter model of motion patterns in confluent cell monolayers

Autor: Eric Bertin, Kaja Kostanjevec, Silke Henkes, Rastko Sknepnek, J. Martin Collinson

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-15164-5⟩
Henkes, S, Kostanjevec, K, Collinson, J M, Sknepnek, R & Bertin, E 2020, ' Dense active matter model of motion patterns in confluent cell monolayers ', Nature Communications, vol. 11, 1405 (2020) . https://doi.org/10.1038/s41467-020-15164-5
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)

Epithelial cell monolayers show remarkable displacement and velocity correlations over distances of ten or more cell sizes that are reminiscent of supercooled liquids and active nematics. We show that many observed features can be described within th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad06511d5eeceb8d78de92a8812a571
https://hal.archives-ouvertes.fr/hal-03043253/document

Stratification relieves constraints from steric hindrance in the generation of compact acto-myosin asters at the membrane cortex

Autor: Rastko Sknepnek, Amit Das, Satyajit Mayor, Darius Vasco Köster, Madan Rao, Abrar Bhat

Publikováno v: Science Advances

Stratified assembly of active components drives a tight huddle of proteins on the membrane.
Recent in vivo studies reveal that several membrane proteins are driven to form nanoclusters by active contractile flows arising from localized dynamic p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9c28794004d57015f29ca161350112
http://wrap.warwick.ac.uk/132301/13/WRAP-stratification-relieves-constraints-steric-hindrance-compact-asters-Das-2020.pdf