Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rastislav Tamaskovic"'
Autor:
Rastislav Tamaskovic, Martin Schwill, Gabriela Nagy-Davidescu, Christian Jost, Dagmar C. Schaefer, Wouter P. R. Verdurmen, Jonas V. Schaefer, Annemarie Honegger, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
Targeted therapy of ErbB2-dependent tumours often provokes an adaptive response leading to reactivation of the PI3K/AKT pathway. Here the authors identify an ErbB3-independent compensatory mechanism comprising Ras/PI3K activation directly by ErbB2, a
Externí odkaz:
https://doaj.org/article/e0be6e1f3bd245178be008000c067b2e
Autor:
Andreas Plückthun, Robert Waibel, H. Kaspar Binz, Roger Schibli, Birgit Dreier, Gabriela Nagy-Davidescu, Rastislav Tamaskovic, Christine de Pasquale, Michael T. Stumpp, Martin Kawe, Christian Zahnd
Supplementary Materials, Table 1-6, Figures 1-10 from Efficient Tumor Targeting with High-Affinity Designed Ankyrin Repeat Proteins: Effects of Affinity and Molecular Size
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285a929f6f45cc62b35a0d4b774e9ce3
https://doi.org/10.1158/0008-5472.22387148.v1
https://doi.org/10.1158/0008-5472.22387148.v1
Autor:
Martin Schwill, Florian Kast, Andreas Plückthun, Forest M. White, Rastislav Tamaskovic, Aaron Gajadhar
Publikováno v:
PMC
Drug-induced compensatory signaling and subsequent rewiring of the signaling pathways that support cell proliferation and survival promote the development of acquired drug resistance in tumors. Here, we sought to analyze the adaptive kinase response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5358d80ba0d647adb0c969228c7b0ccd
https://www.zora.uzh.ch/id/eprint/174010/
https://www.zora.uzh.ch/id/eprint/174010/
Publikováno v:
Journal of Biological Chemistry. 279:35228-35235
NDR (nuclear Dbf2-related) kinase belongs to a family of kinases that is highly conserved throughout the eukaryotic world. We showed previously that NDR is regulated by phosphorylation and by the Ca2+-binding protein, S100B. The budding yeast relativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea7a3c0e77475e1ed272ec39acc9894
https://doi.org/10.1074/jbc.m404542200
https://doi.org/10.1074/jbc.m404542200
Autor:
Jianhua Feng, Derek P. Brazil, Daniel Hess, Zhong-Zhou Yang, Rastislav Tamaskovic, Brian A. Hemmings, Adrian Merlo
Publikováno v:
Journal of Biological Chemistry. 279:35510-35517
The tumor suppressor p53 is commonly inhibited under conditions in which the phosphatidylinositide 3'-OH kinase/protein kinase B (PKB)Akt pathway is activated. Intracellular levels of p53 are controlled by the E3 ubiquitin ligase Mdm2. Here we show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615cf5d8e432ce47029aab2895b94527
https://doi.org/10.1074/jbc.m404936200
https://doi.org/10.1074/jbc.m404936200
Autor:
Brian A. Hemmings, Alexander Hergovich, Rastislav Tamaskovic, Samuel J. Bichsel, Mario R. Stegert
Publikováno v:
Journal of Biological Chemistry. 279:23806-23812
Nuclear Dbf2-related (NDR) protein kinases are a family of AGC group kinases that are involved in the regulation of cell division and cell morphology. We describe the cloning and characterization of the human and mouse NDR2, a second mammalian isofor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d1885d1542c50f7c9b7dbef4c74f7f
https://doi.org/10.1074/jbc.m402472200
https://doi.org/10.1074/jbc.m402472200
Publikováno v:
Methods in enzymology. 503
Designed ankyrin repeat proteins (DARPins) have been developed into a robust and versatile scaffold for binding proteins. High-affinity binders are routinely selected by ribosome display and phage display. DARPins have entered clinical trials and hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b7bb9ada70cb7e89ca7b42c321eba75
https://pubmed.ncbi.nlm.nih.gov/22230567
https://pubmed.ncbi.nlm.nih.gov/22230567
Designed ankyrin repeat proteins (DARPins) have been developed into a robust and versatile scaffold for binding proteins. High-affinity binders are routinely selected by ribosome display and phage display. DARPins have entered clinical trials and hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c568f3ef49a1e0a5212b7716b7f86d7
https://doi.org/10.1016/b978-0-12-396962-0.00005-7
https://doi.org/10.1016/b978-0-12-396962-0.00005-7
Autor:
Robert Waibel, Christian Zahnd, Martin Kawe, H. Kaspar Binz, Christine de Pasquale, Andreas Plückthun, Roger Schibli, Gabriela Nagy-Davidescu, Rastislav Tamaskovic, Michael T. Stumpp, Birgit Dreier
Slow-clearing, tumor-targeting proteins such as monoclonal antibodies typically exhibit high tumor accumulation but low tissue contrast, whereas intermediate-sized proteins such as scFvs show faster clearance but only moderate tumor accumulation. For
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47be495da71e3096094dd63a8719801e
https://www.zora.uzh.ch/id/eprint/39967/
https://www.zora.uzh.ch/id/eprint/39967/
Autor:
Samuel J. Bichsel, Mario R. Stegert, Rastislav Tamaskovic, Brian A. Hemmings, Alexander Hergovich
NDR protein kinases are involved in the regulation of cell cycle progression and morphology. NDR1/NDR2 protein kinase is activated by phosphorylation on the activation loop phosphorylation site Ser281/Ser282 and the hydrophobic motif phosphorylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce45d8e38afb3c76afc2ad91eb7a2f4
https://europepmc.org/articles/PMC1316964/
https://europepmc.org/articles/PMC1316964/