Short-range cytokine gradients to mimic paracrine cell interactions in vitro

Autor: Ansorge, Michael, Rastig, Nadine, Steinborn, Ralph, König, Tina, Baumann, Lars, Möller, Stephanie, Schnabelrauch, Matthias, Cross, Michael, Werner, Carsten, Beck-Sickinger, Annette, Pompe, Tilo

Cell fate decisions in many physiological processes, including embryogenesis, stem cell niche homeostasis and wound healing, are regulated by secretion of small signaling proteins, called cytokines, from source cells to their neighbors or into the en

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Short-range cytokine gradients to mimic paracrine cell interactions in vitro.

Autor: Ansorge M; Institute of Biochemistry, Universität Leipzig, Johannisallee 21/23, 04103 Leipzig, Germany., Rastig N; Institute of Biochemistry, Universität Leipzig, Johannisallee 21/23, 04103 Leipzig, Germany., Steinborn R; Institute of Biochemistry, Universität Leipzig, Johannisallee 21/23, 04103 Leipzig, Germany., König T; Institute of Biochemistry, Universität Leipzig, Johannisallee 21/23, 04103 Leipzig, Germany., Baumann L; Institute of Biochemistry, Universität Leipzig, Johannisallee 21/23, 04103 Leipzig, Germany., Möller S; Biomaterials Department, INNOVENT e. V., Prüssingstraße 27B, 07745 Jena, Germany., Schnabelrauch M; Biomaterials Department, INNOVENT e. V., Prüssingstraße 27B, 07745 Jena, Germany., Cross M; Department of Hematology, Oncology and Hemostasiology, Universität Leipzig, Johannisallee 32A, 04103 Leipzig, Germany., Werner C; Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden, Budapester Straße 27, 01069 Dresden, Germany; Center for Regenerative Therapies Dresden, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany., Beck-Sickinger AG; Institute of Biochemistry, Universität Leipzig, Johannisallee 21/23, 04103 Leipzig, Germany., Pompe T; Institute of Biochemistry, Universität Leipzig, Johannisallee 21/23, 04103 Leipzig, Germany; Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden, Budapester Straße 27, 01069 Dresden, Germany. Electronic address: tilo.pompe@uni-leipzig.de.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2016 Feb 28; Vol. 224, pp. 59-68. Date of Electronic Publication: 2016 Jan 05.