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SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells.

Autor: Obara EAA; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark., Aguilar-Morante D; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark., Rasmussen RD; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark., Frias A; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark., Vitting-Serup K; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark.; Biotech Research and Innovation Centre, Faculty of Health and Medical Sciences, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, DK-2200, Denmark.; Department of Computational and RNA Biology, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, Copenhagen, DK-2200, Denmark., Lim YC; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark., Elbæk KJ; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark., Pedersen H; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark., Vardouli L; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark., Jensen KE; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark., Skjoth-Rasmussen J; Department of Neurosurgery, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, DK-2100, Denmark., Brennum J; Department of Neurosurgery, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, DK-2100, Denmark., Tuckova L; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, Olomouc, 77515, Czech Republic.; University Hospital Olomouc, Hnevotinska 3, Olomouc, 77515, Czech Republic., Strauss R; Genome Integrity Unit, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark., Dinant C; Genome Integrity Unit, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark., Bartek J; Genome Integrity Unit, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark.; Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institute, Scheeles vag 2, Stockholm, 17177, Sweden., Hamerlik P; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen, DK-2100, Denmark. pkn@cancer.dk.; Department of Drug Design and Pharmacology, Copenhagen University, Jagtvej 160, Copenhagen, DK-2100, Denmark. pkn@cancer.dk.

Publikováno v: Nature communications [Nat Commun] 2020 Sep 18; Vol. 11 (1), pp. 4709. Date of Electronic Publication: 2020 Sep 18.

Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B.

Autor: Staberg M; Department of Radiation Biology, The Finsen Center, Copenhagen University Hospital, Denmark.; Brain Tumor Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark., Rasmussen RD; Brain Tumor Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark., Michaelsen SR; Department of Radiation Biology, The Finsen Center, Copenhagen University Hospital, Denmark.; Brain Tumor Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark., Pedersen H; Brain Tumor Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark., Jensen KE; Brain Tumor Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark., Villingshøj M; Department of Radiation Biology, The Finsen Center, Copenhagen University Hospital, Denmark., Skjoth-Rasmussen J; Department of Neurosurgery, Copenhagen University Hospital, Denmark., Brennum J; Department of Neurosurgery, Copenhagen University Hospital, Denmark., Vitting-Seerup K; Brain Tumor Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark., Poulsen HS; Department of Radiation Biology, The Finsen Center, Copenhagen University Hospital, Denmark., Hamerlik P; Brain Tumor Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark.

Publikováno v: Molecular oncology [Mol Oncol] 2018 Mar; Vol. 12 (3), pp. 406-420. Date of Electronic Publication: 2018 Feb 12.

BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity.

Autor: Rasmussen RD; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen DK-2100, Denmark., Gajjar MK; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen DK-2100, Denmark., Tuckova L; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic., Jensen KE; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen DK-2100, Denmark., Maya-Mendoza A; Genome Integrity Unit, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen DK-2100, Denmark., Holst CB; Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200-DK, Denmark., Møllgaard K; Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200-DK, Denmark., Rasmussen JS; Department of Neurosurgery, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen DK-2100, Denmark., Brennum J; Department of Neurosurgery, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen DK-2100, Denmark., Bartek J Jr; Department of Neurosurgery, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen DK-2100, Denmark.; Department of Medicine, Unit of Microbial Pathogenesis, Karolinska Institutet and Department of Neurosurgery, Karolinska University Hospital, Solna 171 76, Stockholm, Sweden., Syrucek M; Department of Pathology, Hospital Na Homolce, Roentgenova 2, 150 30 Praha 5, Czech Republic., Sedlakova E; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University and University Hospital Olomouc, Hnevotinska 3, Olomouc 77515, Czech Republic., Andersen KK; Statistics, Bioinformatics and Registry Unit, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen DK-2100, Denmark., Frederiksen MH; Statistics, Bioinformatics and Registry Unit, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen DK-2100, Denmark., Bartek J; Genome Integrity Unit, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen DK-2100, Denmark.; Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institute, Scheeles vag 2, Stockholm 17177, Sweden., Hamerlik P; Brain Tumor Biology, Danish Cancer Society Research Center, Strandboulevarden 49, Copenhagen DK-2100, Denmark.; Department of Radiation Biology, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen 2100-DK, Denmark.

Publikováno v: Nature communications [Nat Commun] 2016 Nov 15; Vol. 7, pp. 13398. Date of Electronic Publication: 2016 Nov 15.

Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis.

Autor: Feng X; Department of Neurosciences at Cleveland Clinic, Cleveland, Ohio, USA., Szulzewsky F; Cellular Neurosciences, Max Delbrück Center for Molecular Medicine, Berlin, Germany., Yerevanian A; Department of Neurosciences at Cleveland Clinic, Cleveland, Ohio, USA.; Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Chen Z; Department of Neurosciences at Cleveland Clinic, Cleveland, Ohio, USA., Heinzmann D; Department of Neurosciences at Cleveland Clinic, Cleveland, Ohio, USA.; Department of Cardiology at Tübingen University School of Medicine, Tübingen, Germany., Rasmussen RD; Department of Neurosciences at Cleveland Clinic, Cleveland, Ohio, USA., Alvarez-Garcia V; Department of Neurosciences at Cleveland Clinic, Cleveland, Ohio, USA., Kim Y; Department of Stem Cell Biology and Regenerative Medicine, Cleveland, Ohio, USA., Wang B; Rammelkamp Center for Research, MetroHealth Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Tamagno I; Department of Neurosciences at Cleveland Clinic, Cleveland, Ohio, USA., Zhou H; Department of Immunology at Cleveland Clinic, Cleveland, Ohio, USA., Li X; Department of Immunology at Cleveland Clinic, Cleveland, Ohio, USA., Kettenmann H; Cellular Neurosciences, Max Delbrück Center for Molecular Medicine, Berlin, Germany., Ransohoff RM; Department of Neurosciences at Cleveland Clinic, Cleveland, Ohio, USA.; Neuroinflammation Research Center, Cleveland Clinic, Cleveland, Ohio, USA., Hambardzumyan D; Department of Neurosciences at Cleveland Clinic, Cleveland, Ohio, USA.

Publikováno v: Oncotarget [Oncotarget] 2015 Jun 20; Vol. 6 (17), pp. 15077-94.