Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rasmus W. Mortensen"'
Autor:
Anders Just Pedersen, Christian Janfelt, Kim Troensegaard Nielsen, Rasmus W. Mortensen, André Huss Eriksson, Isabella S. Sørensen, Mette M. Nielsen, Nina Østergaard Knudsen
Publikováno v:
Analytical and Bioanalytical Chemistry. 409:4993-5005
Study of skin penetration and distribution of the drug compounds in the skin is a major challenge in the development of topical drug products for treatment of skin diseases. It is crucial to have fast and efficacious screening methods which can provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60f400ac1b464df4c95185edca7d199
https://doi.org/10.1007/s00216-017-0443-2
https://doi.org/10.1007/s00216-017-0443-2
Autor:
Jonathan Stauber, Kim Troensegaard Nielsen, Rasmus W. Mortensen, David Bonnel, André Huss Eriksson, Raphael Legouffe, Fabien Pamelard
Publikováno v:
Analytical and bioanalytical chemistry. 410(11)
Generation of skin distribution profiles and reliable determination of drug molecule concentration in the target region are crucial during the development process of topical products for treatment of skin diseases like psoriasis and atopic dermatitis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec922e1a8955f042febe8a1fea77c78a
https://pubmed.ncbi.nlm.nih.gov/29546543
https://pubmed.ncbi.nlm.nih.gov/29546543
Publikováno v:
Chirality. 14:305-312
The hydrolysis and acyl migration of biosynthetic S-naproxen-beta-l-O-acyl glucuronide (I) and R-naproxen-beta-l-O-acyl glucuronide (II) was followed by HPLC. Nine first-order kinetic rate constants for the hydrolysis and acyl migration between the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eebeb5d9476c9cd412c43f559f34bd33
https://doi.org/10.1002/chir.10047
https://doi.org/10.1002/chir.10047
Publikováno v:
Chemical Research in Toxicology. 14:1363-1370
A widely held view in drug metabolism and pharmacokinetic studies is that the initial 1-isomer to 2-isomer step in the intramolecular acyl migration of drug ester glucuronides is irreversible, and that alpha-1-O-acyl isomers do not occur under physio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa609106999814966db2fc5737b23629
https://doi.org/10.1021/tx010015q
https://doi.org/10.1021/tx010015q
Publikováno v:
Analytical and bioanalytical chemistry. 406(15)
Desorption electrospray ionization (DESI) mass spectrometry imaging is demonstrated as a detection technique for penetration experiments of drugs in skin. Lidocaine ointment was used as the model compound in ex vivo experiments with whole pig ears as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3dda471da2d3bd47859dde6937ed046
https://pubmed.ncbi.nlm.nih.gov/24722877
https://pubmed.ncbi.nlm.nih.gov/24722877
Autor:
J. Troke, Olivia Corcoran, John C. Lindon, Steen Honoré Hansen, Ulla G. Sidelmann, Claus Cornett, Jeremy K. Nicholson, Rasmus W. Mortensen
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 24(3)
The reactive metabolite S-naproxen-beta-1-O-acyl glucuronide was purified from human urine using solid phase extraction (SPE) and preparative HPLC. The structure was confirmed by 600 MHz 1H NMR. Directly coupled 600 MHz HPLC-1H NMR was used to assign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e703b73208a1f1507068260b8b5caefd
https://pubmed.ncbi.nlm.nih.gov/11199227
https://pubmed.ncbi.nlm.nih.gov/11199227
Autor:
Bonnel, David1, Legouffe, Raphaël1, Eriksson, André H.2, Mortensen, Rasmus W.2, Pamelard, Fabien1, Stauber, Jonathan1,3, Nielsen, Kim T.2 ktidk@leo-pharma.com
Publikováno v:
Analytical & Bioanalytical Chemistry. Apr2018, Vol. 410 Issue 11, p2815-2828. 14p.
This book uniquely summarizes approaches to developing dermatological drugs in a regulated environment from the perspective of the pharmaceutical industry. It brings together the insights of skilled and experienced industry experts to reveal the comp
