Deficiency of T-type voltage-gated calcium channels results in attenuated weight gain and improved endothelium-dependent dilatation of resistance vessels induced by a high-fat diet in mice

Autor: Kate Lykke Lambertsen, Kristoffer Rosenstand, Ditte Gry Ellman, Peter Gennemark, Per Svenningsen, Anna Reznichenko, Kenneth Andersen, Pernille B. Lærkegaard Hansen, Paul M. Vanhoutte, Rasmus Terp

Publikováno v: Rosenstand, K, Andersen, K, Terp, R, Gennemark, P, Ellman, D G, Reznichenko, A, Lambertsen, K L, Vanhoutte, P M, Hansen, P B L & Svenningsen, P 2020, ' Deficiency of T-type voltage-gated calcium channels results in attenuated weight gain and improved endothelium-dependent dilatation of resistance vessels induced by a high-fat diet in mice ', Journal of Physiology and Biochemistry, vol. 76, no. 1, pp. 135-145 . https://doi.org/10.1007/s13105-020-00728-2

The deletion of T-type Ca v3.1 channels may reduce high-fat diet (HFD)-induced weight gain, which correlates positively with obesity and endothelial dysfunction. Therefore, experiments were designed to study the involvement of T-type Ca v3.1 channels

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https://pubmed.ncbi.nlm.nih.gov/32016773