Hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance imaging identifies metabolic phenotypes in patients with heart failure

Autor: Steen Hylgaard Joergensen, Esben Soevsoe S. Hansen, Nikolaj Bøgh, Lotte Bonde Bertelsen, Rasmus Stilling Tougaard, Peter Bisgaard Staehr, Christoffer Laustsen, Henrik Wiggers

Publikováno v: Journal of Cardiovascular Magnetic Resonance, Vol 26, Iss 2, Pp 101095- (2024)

ABSTRACT: Background: Hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance imaging (HP [1-13C]pyruvate CMR) visualizes key steps in myocardial metabolism. The present study aimed to examine patients with heart failure (HF) using HP [1-13C

Externí odkaz: https://doaj.org/article/19eb95468e304c4fa3c2f68b8250a95e

Hyperpolarized [1‐ 13 C]pyruvate combined with the hyperinsulinaemic euglycaemic and hypoglycaemic clamp technique in skeletal muscle in a large animal model

Autor: Christian Østergaard Mariager, Niels Jessen, Rasmus Stilling Tougaard, Christoffer Laustsen, Hans Stødkilde-Jørgensen, Mads Dam Lyhne, Nikolaj Rittig, Mads Bengtsen, Esben Søvsø Szocska Hansen, Niels Møller, Julie Støy

Publikováno v: Bengtsen, M B, Hansen, E S S, Tougaard, R S, Lyhne, M D, Rittig, N F, Støy, J, Jessen, N, Mariager, C Ø, Stødkilde-Jørgensen, H, Møller, N & Laustsen, C 2021, ' Hyperpolarized [1-13 C]pyruvate combined with the hyperinsulinaemic euglycaemic and hypoglycaemic clamp technique in skeletal muscle in a large animal model ', Experimental Physiology, vol. 106, no. 12, pp. 2412-2422 . https://doi.org/10.1113/EP089782

New Findings: What is the central question of this study? Is it possible to combine the hyperpolarized magnetic resonance technique and the hyperinsulinaemic clamp method in order to evaluate skeletal muscle metabolism in a large animal model? What i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8535fb1bc8d487f2641f277114fc8498
https://doi.org/10.1113/ep089782

Remodeling after myocardial infarction and effects of heart failure treatment investigated by hyperpolarized [1-C-13]pyruvate magnetic resonance spectroscopy

Autor: Thomas Ravn Lassen, Marie A. Schroeder, Steffen Ringgaard, Hans Stødkilde-Jørgensen, Won Yong Kim, Christoffer Laustsen, Henrik Wiggers, Hans Erik Bøtker, Rasmus Stilling Tougaard, Haiyun Qi, Esben Søvsø Szocska Hansen, Jakob Lindhardt, Nichlas Riise Jespersen

Publikováno v: Tougaard, R S, Laustsen, C, Lassen, T R, Qi, H, Lindhardt, J L, Schroeder, M, Jespersen, N R, Hansen, E S S, Ringgaard, S, Bøtker, H E, Kim, W Y, Stødkilde-Jørgensen, H & Wiggers, H 2022, ' Remodeling after myocardial infarction and effects of heart failure treatment investigated by hyperpolarized [1-C-13]pyruvate magnetic resonance spectroscopy ', Magnetic Resonance in Medicine, vol. 87, no. 1, pp. 57-69 . https://doi.org/10.1002/mrm.28964

Purpose: Hyperpolarized [1- 13C]pyruvate MRS can measure cardiac metabolism in vivo. We investigated whether [1- 13C]pyruvate MRS could predict left ventricular remodeling following myocardial infarction (MI), long-term left ventricular effects of he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61e9a9dc47538a0e1d47e88d0a8ce28
https://pure.au.dk/portal/da/publications/remodeling-after-myocardial-infarction-and-effects-of-heart-failure-treatment-investigated-by-hyperpolarized-1c13pyruvate-magnetic-resonance-spectroscopy(950c8c89-8770-43ad-9e26-4fbc8729f3d3).html

Radiofrequency ablation lesions in low-, intermediate-, and normal-voltage myocardium: an in vivo study in a porcine heart model

Autor: Rasmus Stilling Tougaard, Jens Cosedis Nielsen, Henrik Jensen, Steen B. Kristiansen, Esben Søvsø Szocska Hansen, Bawer Jalal Tofig, Peter Lukac, Jan Møller Nielsen

Publikováno v: Tofig, B J, Lukac, P, Nielsen, J M, Hansen, E S S, Tougaard, R S, Jensen, H K, Nielsen, J C & Kristiansen, S B 2019, ' Radiofrequency ablation lesions in low-, intermediate-, and normal-voltage myocardium : an in vivo study in a porcine heart model ', Europace, vol. 21, no. 12, pp. 1919-1927 . https://doi.org/10.1093/europace/euz247

Aims Contact force (CF) between radiofrequency (RF) ablation catheter and myocardium and ablation index (AI) correlates with RF lesion depth and width in normal-voltage (>1.5 mV) myocardium (NVM). We investigate the impact of CF on RF lesion depth an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e162cb2a21f26969ac73ffc036122958
https://doi.org/10.1093/europace/euz247

Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances

Autor: Joshua D. Kaggie, Juan D. Sanchez-Heredia, Jan Henrik Ardenkjær-Larsen, Mary A. McLean, Esben Søvsø Szocska Hansen, Christoffer Laustsen, James T. Grist, Ferdia A. Gallagher, Rolf F. Schulte, Rasmus Stilling Tougaard, Frank Riemer

Publikováno v: Magnetic Resonance in Medicine
Grist, J T, Hansen, E S S, Sánchez-Heredia, J D, McLean, M A, Tougaard, R, Riemer, F, Schulte, R F, Kaggie, J D, Ardenkjær-Larsen, J H, Laustsen, C & Gallagher, F A 2020, ' Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances ', Magnetic Resonance in Medicine, vol. 84, no. 4, pp. 1817-1827 . https://doi.org/10.1002/mrm.28238
Grist, J T, Hansen, E S S, Sánchez-Heredia, J D, McLean, M A, Tougaard, R, Riemer, F, Schulte, R F, Kaggie, J D, Ardenkjaer-Larsen, J H, Laustsen, C & Gallagher, F A 2020, ' Creating a clinical platform for carbon-13 studies using the sodium-23 and proton resonances ', Magnetic Resonance in Medicine, vol. 84, no. 4, pp. 1817-1827 . https://doi.org/10.1002/mrm.28238

Purpose: Calibration of hyperpolarized 13C-MRI is limited by the low signal from endogenous carbon-containing molecules and consequently requires 13C-enriched external phantoms. This study investigated the feasibility of using either 23Na-MRI or 1H-M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602174f25c8ac1217cc785078f1b1a86
https://www.repository.cam.ac.uk/handle/1810/304037