Intake of St John's wort improves the glucose tolerance in healthy subjects who ingest metformin compared with metformin alone

Autor: Kim Brøsen, Tore Bjerregaard Stage, Søren Feddersen, Per Damkier, Rasmus Steen Pedersen, Kurt Højlund, John Teilmann Larsen, Mette Marie Hougaard Christensen

Publikováno v: British Journal of Clinical Pharmacology. 79:298-306

Aims Our objective was to investigate the steady-state pharmacokinetic and pharmacodynamic interaction between the antidepressive herbal medicine St John's wort and the antidiabetic drug metformin.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::690a3e4aaef2723f946892ff99af81e6
https://doi.org/10.1111/bcp.12510

The Hypoalgesic Effect of Oxycodone in Human Experimental Pain Models in Relation to the CYP2D6 Oxidation Polymorphism

Autor: Rasmus Steen Pedersen, Thomas P. Enggaard, Lene Noehr-Jensen, Soeren Mikkelsen, Flemming Nielsen, Soeren H. Sindrup, Stine Thorhauge Zwisler, Kim Brøsen

Publikováno v: Zwisler, S T, Enggaard, T P, Noehr-Jensen, L, Pedersen, R S, Mikkelsen, S, Nielsen, F, Brøsen, K, Sindrup, S H & Brøsen, K 2009, ' The hypoalgesic effect of oxycodone in human experimental pain models in relation to the CYP2D6 oxidation polymorphism ', Basic & Clinical Pharmacology & Toxicology, vol. 104, no. 4, pp. 335-344 . https://doi.org/10.1111/j.1742-7843.2009.00378.x

Udgivelsesdato: 2009-Apr Oxycodone is O-demethylated by CYP2D6 to oxymorphone which is a potent micro-receptor agonist. The CYP2D6 oxidation polymorphism divides the Caucasian population in two phenotypes: approximately 8% with no enzyme activity, po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90d04f369a9437049c2f310dda79baa
https://doi.org/10.1111/j.1742-7843.2009.00378.x

Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers

Autor: Kim Brøsen, Rasmus Steen Pedersen, Per Damkier

Publikováno v: University of Southern Denmark
Pedersen, R S, Damkier, P & Brøsen, K 2006, ' Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers ', European Journal of Clinical Pharmacology, vol. 62, pp. 513-521 .

To describe in detail the intravenous, single oral and multiple oral dose enantioselective pharmacokinetics of tramadol in CYP2D6 extensive metabolizers (EMs) and poor metabolizers (PMs).Eight EMs and eight PMs conducted three phases as an open-label

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76205d9a5ce6da4ce32b0465b93402f5
https://doi.org/10.1007/s00228-006-0135-x

CYP2C19*17 increases clopidogrel-mediated platelet inhibition but does not alter the pharmacokinetics of the active metabolite of clopidogrel

Autor: Tore Bjerregaard Stage, Rasmus Steen Pedersen, Pernille Just Vinholt, Alaa Bilal el Achwah, Per Damkier, Flemming Nielsen, Kim Brøsen

Publikováno v: Pedersen, R S, Nielsen, F, Stage, T B, Vinholt, P J, Achwah, A B E, Damkier, P & Brøsen, K 2014, ' CYP2C19*17 increases clopidogrel-mediated platelet inhibition but does not alter the pharmacokinetics of the active metabolite of clopidogrel ', Clinical and Experimental Pharmacology and Physiology, vol. 41, no. 11, pp. 870-878 . https://doi.org/10.1111/1440-1681.12297

The aim of the present study was to determine the impact of CYP2C19*17 on the pharmacokinetics and pharmacodynamics of the active metabolite of clopidogrel and the pharmacokinetics of proguanil. Thus, we conducted an open-label two-phase cross-over s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee568f7916d137fa31b1b4c9ae953bd
https://portal.findresearcher.sdu.dk/da/publications/613b1db8-da98-4fdd-9f06-ba0e39c7514d

A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin

Autor: Kim Brøsen, Flemming Nielsen, Henning Beck-Nielsen, Mette Marie Hougaard Christensen, Rasmus Steen Pedersen, Charlotte Brasch-Andersen, Tore Bjerregaard Stage, Per Damkier

Publikováno v: Hougaard Christensen, M M, Pedersen, R S, Stage, T B, Brasch-Andersen, C, Nielsen, F, Damkier, P, Beck-Nielsen, H & Brøsen, K 2013, ' A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin ', Pharmacogenetics and Genomics, vol. 23, no. 10, pp. 526-534 . https://doi.org/10.1097/FPC.0b013e328364a57d

OBJECTIVE: The aim of this study was to determine the association between the renal clearance (CLrenal) of metformin in healthy Caucasian volunteers and the single-nucleotide polymorphism (SNP) c.808G>T (rs316019) in OCT2 as well as the relevance of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05eb6280be25dc95b2b380eac171bf4
https://portal.findresearcher.sdu.dk/da/publications/9fea3319-3344-49d1-9f57-69ed6cdf3e41