Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Rasmus Siersbæk"'
Autor:
Vignesh Ramesh, Paradesi Naidu Gollavilli, Luisa Pinna, Mohammad Aarif Siddiqui, Adriana Martinez Turtos, Francesca Napoli, Yasmin Antonelli, Aldo Leal‐Egaña, Jesper Foged Havelund, Simon Toftholm Jakobsen, Elisa Le Boiteux, Marco Volante, Nils Joakim Færgeman, Ole N Jensen, Rasmus Siersbæk, Kumar Somyajit, Paolo Ceppi
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp n/a-n/a (2023)
Abstract The epithelial‐to‐mesenchymal transition (EMT) plays a central role in the development of cancer metastasis and resistance to chemotherapy. However, its pharmacological treatment remains challenging. Here, we used an EMT‐focused integr
Externí odkaz:
https://doaj.org/article/f6a02b7c4b9e494a97d706c0ba7228b7
Autor:
Rebecca Broome, Igor Chernukhin, Stacey Jamieson, Kamal Kishore, Evangelia K. Papachristou, Shi-Qing Mao, Carmen Gonzalez Tejedo, Areeb Mahtey, Vasiliki Theodorou, Arnoud J. Groen, Clive D’Santos, Shankar Balasubramanian, Anca Madalina Farcas, Rasmus Siersbæk, Jason S. Carroll
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108776- (2021)
Summary: Estrogen receptor-α (ER) drives tumor development in ER-positive (ER+) breast cancer. The transcription factor GATA3 has been closely linked to ER function, but its precise role in this setting remains unclear. Quantitative proteomics was u
Externí odkaz:
https://doaj.org/article/2f967e69b4e24dc196b740e2f994b931
Autor:
Evangelia K. Papachristou, Kamal Kishore, Andrew N. Holding, Kate Harvey, Theodoros I. Roumeliotis, Chandra Sekhar Reddy Chilamakuri, Soleilmane Omarjee, Kee Ming Chia, Alex Swarbrick, Elgene Lim, Florian Markowetz, Matthew Eldridge, Rasmus Siersbaek, Clive S. D’Santos, Jason S. Carroll
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Chromatin-associated protein complexes play a critical role in the regulation of gene expression in health and disease. Here, the authors describe a sensitive mass spectrometry-based method to monitor the dynamic interactions of endogenous chromatin-
Externí odkaz:
https://doaj.org/article/6d77c38577f14fe9922378d351669816
Autor:
Silvia-E Glont, Evangelia K Papachristou, Ashley Sawle, Kelly A Holmes, Jason S Carroll, Rasmus Siersbaek
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215340 (2019)
Estrogen Receptor alpha (ERα) plays a major role in most breast cancers, and it is the target of endocrine therapies used in the clinic as standard of care for women with breast cancer expressing this receptor. The two methods ChIP-seq (chromatin im
Externí odkaz:
https://doaj.org/article/240c6a016e47436084a7142bf756f9cb
Autor:
Rasmus Siersbæk, Atefeh Rabiee, Ronni Nielsen, Simone Sidoli, Sofie Traynor, Anne Loft, Lars La Cour Poulsen, Adelina Rogowska-Wrzesinska, Ole N. Jensen, Susanne Mandrup
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1443-1455 (2014)
It is becoming increasingly clear that transcription factors operate in complex networks through thousands of genomic binding sites, many of which bind several transcription factors. However, the extent and mechanisms of crosstalk between transcripti
Externí odkaz:
https://doaj.org/article/b6ff40225eff480984ded561723aad8f
Autor:
Rasmus Siersbæk, Songjoon Baek, Atefeh Rabiee, Ronni Nielsen, Sofie Traynor, Nicholas Clark, Albin Sandelin, Ole N. Jensen, Myong-Hee Sung, Gordon L. Hager, Susanne Mandrup
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1434-1442 (2014)
Transcription factors have recently been shown to colocalize in hotspot regions of the genome, which are further clustered into super-enhancers. However, the detailed molecular organization of transcription factors at hotspot regions is poorly define
Externí odkaz:
https://doaj.org/article/cb51e836322e4c74a6e064a23a75aebb
Autor:
Sabina C. Cosulich, Jason S. Carroll, Robert McEwen, Igor Chernukhin, Mandy Lawson, Azadeh Cheraghchi-Bashi, Urszula M. Polanska, Anna D. Staniszewska, Larissa S. Carnevalli, Jon O. Curwen, Oona Delpuech, Rasmus Siersbaek, Claire Crafter, Chrysiis Michaloglou
Supplementary Figure S1. Vistusertib (AZD2014) causes a decrease in RB phosphorylation in the absence of cell cycle arrest. Supplementary Figure S2. Different mTOR inhibitors in combination with palbociclib cause a decrease in cell viability. Supplem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2971446864fbedb32439af08aab612
https://doi.org/10.1158/1535-7163.22510243
https://doi.org/10.1158/1535-7163.22510243
Autor:
Sabina C. Cosulich, Jason S. Carroll, Robert McEwen, Igor Chernukhin, Mandy Lawson, Azadeh Cheraghchi-Bashi, Urszula M. Polanska, Anna D. Staniszewska, Larissa S. Carnevalli, Jon O. Curwen, Oona Delpuech, Rasmus Siersbaek, Claire Crafter, Chrysiis Michaloglou
The cyclin dependent kinase (CDK)–retinoblastoma (RB)–E2F pathway plays a critical role in the control of cell cycle in estrogen receptor–positive (ER+) breast cancer. Small-molecule inhibitors of CDK4/6 have shown promise in this tumor type in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a430fac5fb19944258d4dc125065e6b
https://doi.org/10.1158/1535-7163.c.6539551.v1
https://doi.org/10.1158/1535-7163.c.6539551.v1
Autor:
Vignesh Ramesh, Paradesi Naidu Gollavilli, Luisa Pinna, Mohammad Aarif Siddiqui, Simon Toftholm Jakobsen, Elisa Le Boiteux, Karen Ege Olsen, Ole Nørregaard Jensen, Rasmus Siersbæk, Kumar Somyajit, Paolo Ceppi
Epithelial to mesenchymal transition (EMT) is a developmental cellular program driving metastasis and chemo-resistance in cancer, but its pharmacological treatment has been so far challenging. Targeting deregulated metabolic processes in cancer is em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::229a5b93a3c21e71de0a819e454b6871
https://doi.org/10.1101/2023.01.19.524677
https://doi.org/10.1101/2023.01.19.524677
Autor:
Carmen Gonzalez Tejedo, Kamal Kishore, Areeb Mahtey, Shi-Qing Mao, Clive D'Santos, Stacey Jamieson, Arnoud J. Groen, Rebecca Broome, Shankar Balasubramanian, Rasmus Siersbæk, Igor Chernukhin, Evangelia K. Papachristou, Vasiliki Theodorou, Anca M. Farcas, Jason S. Carroll
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108776-(2021)
Broome, R, Chernukhin, I, Jamieson, S, Kishore, K, Papachristou, E K, Mao, S-Q, Tejedo, C G, Mahtey, A, Theodorou, V, Groen, A J, D'Santos, C, Balasubramanian, S, Farcas, A M, Siersbaek, R & Carroll, J S 2021, ' TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions ', Cell Reports, vol. 34, no. 8, 108776 . https://doi.org/10.1016/j.celrep.2021.108776
Cell Reports
Broome, R, Chernukhin, I, Jamieson, S, Kishore, K, Papachristou, E K, Mao, S-Q, Tejedo, C G, Mahtey, A, Theodorou, V, Groen, A J, D'Santos, C, Balasubramanian, S, Farcas, A M, Siersbaek, R & Carroll, J S 2021, ' TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions ', Cell Reports, vol. 34, no. 8, 108776 . https://doi.org/10.1016/j.celrep.2021.108776
Cell Reports
Summary Estrogen receptor-α (ER) drives tumor development in ER-positive (ER+) breast cancer. The transcription factor GATA3 has been closely linked to ER function, but its precise role in this setting remains unclear. Quantitative proteomics was us