Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rasmus N. Klitgaard"'
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Ciprofloxacin is a potent antibacterial drug that is widely used in human clinical applications. As a consequence of its extensive use, resistance has emerged in almost all clinically relevant bacterial species. A mean to combat the observed ciproflo
Externí odkaz:
https://doaj.org/article/4f71cc9a1e2c45ffb323ab7a2aea140c
Publikováno v:
Current Drug Discovery Technologies. 16:272-277
Background:One of many strategies to overcome antibiotic resistance is the discovery of compounds targeting cellular processes, which have not yet been exploited.Materials and Methods:Using various genetic tools, we constructed a novel high throughpu
Autor:
Zbigniew Rozynek, Elisabeth Lindbo Hansen, E. C. dos Santos, Leander Michels, Alexander Mikkelsen, Tomás S. Plivelic, Rasmus N. Klitgaard, Jon Otto Fossum, Heloisa N. Bordallo, Anders Løbner-Olesen, Rasmus Hartmann-Petersen
Publikováno v:
dos Santos, E C, Rozynek, Z, Hansen, E L, Hartmann-Petersen, R, Klitgaard, R N, Løbner-Olesen, A, Michels, L, Mikkelsen, A, Plivelic,, Nunes Bordallo, H & Fossum, J O 2017, ' Ciprofloxacin intercalated in fluorohectorite clay : identical pure drug activity and toxicity with higher adsorption and controlled release rate ', R S C Advances, vol. 7, no. 43, pp. 26537-26545 . https://doi.org/10.1039/c7ra01384a
26537-26545
RSC Advances
26537-26545
RSC Advances
Different natural clay minerals, including halloysite, montmorillonite and kaolinite, have been proven to be efficient drug carriers providing for high and long lasting drug concentrations owing to their adsorption capacity and ion exchange property.
Autor:
Paul R. Hansen, Rasmus N. Klitgaard, Håvard Jenssen, Reidar Lund, Peter W. Thulstrup, Thomas T. Thomsen, Abdullah Lone, Josefine Eilsø Nielsen, Anders Løbner-Olesen
Publikováno v:
Lone, A, Thomsen, T T, Nielsen, J E, Thulstrup, P W, Klitgaard, R N, Løbner-Olesen, A, Lund, R, Jenssen, H & Hansen, P R 2019, ' Structure-Activity Study of an All-D Antimicrobial Octapeptide D2D ', Molecules, vol. 24, no. 24, 4571 . https://doi.org/10.3390/molecules24244571
Molecules
Volume 24
Issue 24
'Molecules ', vol: 24, pages: 4571-1-4571-17 (2019)
Molecules
Volume 24
Issue 24
'Molecules ', vol: 24, pages: 4571-1-4571-17 (2019)
The increasing emergence of multi-drug resistant bacteria is a serious threat to public health worldwide. Antimicrobial peptides have attracted attention as potential antibiotics since they are present in all multicellular organisms and act as a firs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948999407bd7fe7633a6bb429e040bea
https://curis.ku.dk/portal/da/publications/structureactivity-study-of-an-alld-antimicrobial-octapeptide-d2d(ebba6ef3-d469-44b8-b89e-d9cf371d1e70).html
https://curis.ku.dk/portal/da/publications/structureactivity-study-of-an-alld-antimicrobial-octapeptide-d2d(ebba6ef3-d469-44b8-b89e-d9cf371d1e70).html
Autor:
Charlotte Dahlmann Liboriussen, Peter W. Thulstrup, Rasmus N. Klitgaard, Godefroid Charbon, Sonia I. Maffioli, Stefano Donadio, Anders Løbner-Olesen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Charbon, G, Klitgaard, R N, Liboriussen, C D, Thulstrup, P W, Maffioli, S I, Donadio, S & Løbner-Olesen, A 2018, ' Iron chelation increases the tolerance of Escherichia coli to hyper-replication stress ', Scientific Reports, vol. 8, no. 1, 10550 . https://doi.org/10.1038/s41598-018-28841-9
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Charbon, G, Klitgaard, R N, Liboriussen, C D, Thulstrup, P W, Maffioli, S I, Donadio, S & Løbner-Olesen, A 2018, ' Iron chelation increases the tolerance of Escherichia coli to hyper-replication stress ', Scientific Reports, vol. 8, no. 1, 10550 . https://doi.org/10.1038/s41598-018-28841-9
In Escherichia coli, an increase in the frequency of chromosome replication is lethal. In order to identify compounds that affect chromosome replication, we screened for molecules capable of restoring the viability of hyper-replicating cells. We made
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 9 (2018)
Klitgaard, R N, Jana, B, Guardabassi, L, Nielsen, K L & Løbner-Olesen, A 2018, ' DNA Damage Repair and Drug Efflux as Potential Targets for Reversing Low or Intermediate Ciprofloxacin Resistance in E. coli K-12 ', Frontiers in Microbiology, vol. 9, 1438 . https://doi.org/10.3389/fmicb.2018.01438
Frontiers in Microbiology, Vol 9 (2018)
Klitgaard, R N, Jana, B, Guardabassi, L, Nielsen, K L & Løbner-Olesen, A 2018, ' DNA Damage Repair and Drug Efflux as Potential Targets for Reversing Low or Intermediate Ciprofloxacin Resistance in E. coli K-12 ', Frontiers in Microbiology, vol. 9, 1438 . https://doi.org/10.3389/fmicb.2018.01438
Ciprofloxacin is a potent antibacterial drug that is widely used in human clinical applications. As a consequence of its extensive use, resistance has emerged in almost all clinically relevant bacterial species. A mean to combat the observed ciproflo
Autor:
Lykke Haastrup Hansen, Eleni Ntokou, Rasmus N. Klitgaard, Jacob Kongsted, Nicolai Mathias Trædholm, Birte Vester, Daniel Biltoft, Katrine Nørgaard
Publikováno v:
Klitgaard, R N, Ntokou, E, Nørgaard, K, Biltoft, D, Hansen, L H, Trædholm, N M, Kongsted, J & Vester, B 2015, ' Mutations in the bacterial ribosomal protein l3 and their association with antibiotic resistance ', Antimicrobial Agents and Chemotherapy, vol. 59, no. 6, pp. 3518-28 . https://doi.org/10.1128/AAC.00179-15
Different groups of antibiotics bind to the peptidyl transferase center (PTC) in the large subunit of the bacterial ribosome. Resistance to these groups of antibiotics has often been linked with mutations or methylations of the 23S rRNA. In recent ye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09798421bf6732109feea9e1182d80f8
https://findresearcher.sdu.dk:8443/ws/files/129083452/Mutations_in_the_bacterial_ribosomal_protein_l3_and_their_association_with_antibiotic_resistance.pdf
https://findresearcher.sdu.dk:8443/ws/files/129083452/Mutations_in_the_bacterial_ribosomal_protein_l3_and_their_association_with_antibiotic_resistance.pdf