Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rasmus J O Sjögren"'
Autor:
Luca A Lotta, Robert A Scott, Stephen J Sharp, Stephen Burgess, Jian'an Luan, Therese Tillin, Amand F Schmidt, Fumiaki Imamura, Isobel D Stewart, John R B Perry, Luke Marney, Albert Koulman, Edward D Karoly, Nita G Forouhi, Rasmus J O Sjögren, Erik Näslund, Juleen R Zierath, Anna Krook, David B Savage, Julian L Griffin, Nishi Chaturvedi, Aroon D Hingorani, Kay-Tee Khaw, Inês Barroso, Mark I McCarthy, Stephen O'Rahilly, Nicholas J Wareham, Claudia Langenberg
Publikováno v:
PLoS Medicine, Vol 13, Iss 11, p e1002179 (2016)
BackgroundHigher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but it is not known whether this association is causal. We undertook large-
Externí odkaz:
https://doaj.org/article/83944e1595d0460791be9b9ab3a376df
Autor:
Julie Massart, Rasmus J. O. Sjögren, Brendan Egan, Christian Garde, Magnus Lindgren, Weifeng Gu, Duarte M. S. Ferreira, Mutsumi Katayama, Jorge L. Ruas, Romain Barrès, Donal J. O’Gorman, Juleen R. Zierath, Anna Krook
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Exercise induces structural and functional adaptations in skeletal muscle that involve transcriptomic remodeling, including of miRNA expression. Here the authors examine the expression of miRNAs in human muscle following exercise training and investi
Externí odkaz:
https://doaj.org/article/16278dcd90674810b94f7f82429c7317
Autor:
Christoph Handschin, Alexander V. Chibalin, Jun Harada, Rasmus J. O. Sjögren, Thomas Moritz, Erik Näslund, Håkan Karlsson, Juleen R. Zierath, Elin Chorell, Shintaro Katayama, Regula Furrer, David Rizo-Roca, Anna Krook
Publikováno v:
Diabetologia
Aims/hypothesisIncreased levels of branched-chain amino acids (BCAAs) are associated with type 2 diabetes pathogenesis. However, most metabolomic studies are limited to an analysis of plasma metabolites under fasting conditions, rather than the dynam
Autor:
Jorge L. Ruas, Juleen R. Zierath, Magnus Lindgren, Rasmus J. O. Sjögren, Christian Garde, Brendan Egan, Donal J. O’Gorman, Anna Krook, Mutsumi Katayama, Duarte M. S. Ferreira, Julie Massart, Romain Barrès, Weifeng Gu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Massart, J, Sjögren, R J O, Egan, B, Garde, C, Lindgren, M, Gu, W, Ferreira, D M S, Katayama, M, Ruas, J L, Barrès, R, O'Gorman, D J, Zierath, J R & Krook, A 2021, ' Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism ', Nature Communications, vol. 12, no. 1, 5948 . https://doi.org/10.1038/s41467-021-26095-0
Nature Communications
Massart, J, Sjögren, R J O, Egan, B, Garde, C, Lindgren, M, Gu, W, Ferreira, D M S, Katayama, M, Ruas, J L, Barrès, R, O'Gorman, D J, Zierath, J R & Krook, A 2021, ' Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism ', Nature Communications, vol. 12, no. 1, 5948 . https://doi.org/10.1038/s41467-021-26095-0
Nature Communications
Skeletal muscle is a highly adaptable tissue and remodels in response to exercise training. Using short RNA sequencing, we determine the miRNA profile of skeletal muscle from healthy male volunteers before and after a 14-day aerobic exercise training
Autor:
Jonathan M. Mudry, Morten Arendt Rasmussen, Petter S. Alm, Shashank Gupta, Juleen R. Zierath, Romain Barrès, Julie Massart, Rasmus J. O. Sjögren, Lars R. Ingerslev, Thais de Castro Barbosa, Laurène Vetterli, Ida Donkin, Soetkin Versteyhe, Anna Krook
Publikováno v:
Molecular Metabolism, Vol 5, Iss 3, Pp 184-197 (2016)
Molecular Metabolism
Molecular Metabolism
Objectives Chronic and high consumption of fat constitutes an environmental stress that leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally remodels the epigenome of spermatozoa and metabolism of the offspring. M
Autor:
David G. Lassiter, Juleen R. Zierath, Erik Näslund, Carolina Nylén, Anna Krook, Harriet Wallberg-Henriksson, Alexander V. Chibalin, Rasmus J. O. Sjögren
Publikováno v:
Diabetologia
Lassiter, D G, Nylén, C, Sjögren, R J O, Chibalin, A V, Wallberg-Henriksson, H, Näslund, E, Krook, A & Zierath, J R 2018, ' FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle ', Diabetologia, vol. 61, no. 2, pp. 424-432 . https://doi.org/10.1007/s00125-017-4451-8
Lassiter, D G, Nylén, C, Sjögren, R J O, Chibalin, A V, Wallberg-Henriksson, H, Näslund, E, Krook, A & Zierath, J R 2018, ' FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle ', Diabetologia, vol. 61, no. 2, pp. 424-432 . https://doi.org/10.1007/s00125-017-4451-8
Aims/hypothesis Insulin-mediated signals and AMP-activated protein kinase (AMPK)-mediated signals are activated in response to physiological conditions that represent energy abundance and shortage, respectively. Focal adhesion kinase (FAK) is implica
Autor:
Niclas Franck, Leonidas S. Lundell, Julie Massart, Juleen R. Zierath, Jonathan M. Mudry, Rasmus J. O. Sjögren, Donal J. O’Gorman, Anna Krook, Brendan Egan
Publikováno v:
Diabetes. 66(7)
MicroRNAs have emerged as important regulators of glucose and lipid metabolism in several tissues; however, their role in skeletal muscle remains poorly characterized. We determined the effects of the miR-29 family on glucose metabolism, lipid metabo
Publikováno v:
Research and Perspectives in Endocrine Interactions ISBN: 9783319727899
MicroRNAs (miRNA) are a noncoding RNA species that play important roles in the regulation of gene expression. Since miRNAs are able to target multiple genes simultaneously, miRNAs provide a mechanism for efficiently modulating a whole pathway to chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12ee359ab39885641fbeb08c06d46bdf
https://doi.org/10.1007/978-3-319-72790-5_6
https://doi.org/10.1007/978-3-319-72790-5_6
Autor:
Juleen R. Zierath, Hanneke Boon, Ulrika Widegren, Rasmus J. O. Sjögren, Julie Massart, Emil Kostovski, Nils Hjeltnes, Brendan Egan, Per Ole Iversen, Alexander V. Chibalin
Publikováno v:
Physiological Reports
The effects of long-term physical inactivity on the expression of microRNAs involved in the regulation of skeletal muscle mass in humans are largely unknown. MicroRNAs are short, noncoding RNAs that fine-tune target expression through mRNA degradatio
Publikováno v:
The Biochemical journal. 472(2)
miRNAs regulate protein abundance and control diverse aspects of cellular processes and biological functions in metabolic diseases, such as obesity and type 2 diabetes (T2D). Let (lethal)-7 miRNAs specifically targets genes associated with T2D and ha