Establishment of a fluorescent reporter of RNA-polymerase II activity to identify dormant cells

Autor: Rasmus Freter, Paola Falletta, Omid Omrani, Mahdi Rasa, Katharine Herbert, Francesco Annunziata, Alberto Minetti, Anna Krepelova, Lisa Adam, Sandra Käppel, Tina Rüdiger, Zhao-Qi Wang, Colin R. Goding, Francesco Neri

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

The identification and characterisation of dormant cells is currently difficult. Here the authors report Optical Stem Cell Activity Reporter (OSCAR) to assess RNA polymerase II activity and identify dormant cell populations in intestinal epithelial c

Externí odkaz: https://doaj.org/article/fe29dc36efb94fd6a94dead8d21a2d0f

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma

Autor: Christopher J. Kershaw, Michael Hölzel, Richard Lisle, Ze'ev Ronai, Thomas Tüting, Paola Falletta, Tatjana Sauka-Spengler, Amy Kenyon, Colin R. Goding, Maike Effern, Rasmus Freter, Anne E. Willis, Mark R. Middleton, Robert Siddaway, Xin Lu, Luis Sánchez-del-Campo, Graham D. Pavitt, Jagat Chauhan, Matthew J. Daniels, Francesca M. Buffa

Publikováno v: Falletta, P, Sanchez-del-Campo, L, Chauhan, J, Effern, M, Kenyon, A, Kershaw, C J, Siddaway, R, Lisle, R J, Freter, R, Daniels, M J, Lu, X, Tüting, T, Middleton, M, Buffa, F M, Willis, A E, Pavitt, G D, Ronai, Z A, Sauka-Spengler, T, Hölzel, M & Goding, C R 2017, ' Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma. ', Genes and development, vol. 31, no. 1, pp. 18-33 . https://doi.org/10.1101/gad.290940.116

The intratumor microenvironment generates phenotypically distinct but interconvertible malignant cell subpopulations that fuel metastatic spread and therapeutic resistance. Whether different microenvironmental cues impose invasive or therapy-resistan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65856e223778261b0e8b4d266238c47d
https://doi.org/10.1101/gad.290940.116

Directed phenotype switching as an effective antimelanoma strategy

Autor: Soledad Chazarra, María Piedad Fernández-Pérez, Rasmus Freter, Luis Sánchez-del-Campo, Colin R. Goding, Juan Cabezas-Herrera, Magalí Sáez-Ayala, Antonio Piñero-Madrona, Mark R. Middleton, María F. Montenegro, José Neptuno Rodríguez-López

Publikováno v: Cancer cell. 24(1)

SummaryTherapeutic resistance in melanoma and other cancers arises via irreversible genetic, and dynamic phenotypic, heterogeneity. Here, we use directed phenotype switching in melanoma to sensitize melanoma cells to lineage-specific therapy. We show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e544b0f83d805e0ee53c92082ce930d
http://ora.ox.ac.uk/objects/uuid:161ac995-067a-4915-916a-56ec423c0522

Transcriptional Quiescence of Hematopoietic Stem Cells

Autor: Rasmus Freter

Publikováno v: Advances in Hematopoietic Stem Cell Research

Haematopoietic stem cells (HSC) have the exceptional capacity to undergo continuous selfrenewal and differentiation into multiple lineages, which is essential for haematopoietic homeostasis and response to injury. To achieve this life long function,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94acee7e8a9fefb5e753261aff06b441
http://www.intechopen.com/articles/show/title/transcriptional-quiescence-of-haematopoietic-stem-cells

09-P086 Down-regulation of mRNA transcription in melanocyte stem cells

Autor: Masatake Osawa, Rasmus Freter, Shin-Ichi Nishikawa

Publikováno v: Mechanisms of Development. 126

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45d89dbecbe43818dc964177398504b