Výsledky vyhledávání - "Rasmus, Kjøbsted"

Akademický článek

In-depth phosphoproteomic profiling of the insulin signaling response in heart tissue and cardiomyocytes unveils canonical and specialized regulation

Autor: Jonathan Samuel Achter, Estefania Torres Vega, Andrea Sorrentino, Konstantin Kahnert, Katrine Douglas Galsgaard, Pablo Hernandez-Varas, Michael Wierer, Jens Juul Holst, Jørgen Frank Pind Wojtaszewski, Robert William Mills, Rasmus Kjøbsted, Alicia Lundby

Publikováno v: Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-16 (2024)

Abstract Background Insulin signaling regulates cardiac substrate utilization and is implicated in physiological adaptations of the heart. Alterations in the signaling response within the heart are believed to contribute to pathological conditions su

Externí odkaz: https://doaj.org/article/7f7d63dc57134c099c235fc73a14ffc2

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Akademický článek

Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution

Autor: Ana Martinez-Val, Dorte B. Bekker-Jensen, Sophia Steigerwald, Claire Koenig, Ole Østergaard, Adi Mehta, Trung Tran, Krzysztof Sikorski, Estefanía Torres-Vega, Ewa Kwasniewicz, Sólveig Hlín Brynjólfsdóttir, Lisa B. Frankel, Rasmus Kjøbsted, Nicolai Krogh, Alicia Lundby, Simon Bekker-Jensen, Fridtjof Lund-Johansen, Jesper V. Olsen

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Protein activity regulated by phosphorylation can result in subcellular relocation. Here, the authors present a high throughput spatial phosphoproteomics approach to profile six subcellular compartments, providing insights into EGFR and stress signal

Externí odkaz: https://doaj.org/article/e78dc7fb75d141e6a226079bfaa02397

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Akademický článek

Direct small molecule ADaM-site AMPK activators reveal an AMPKγ3-independent mechanism for blood glucose lowering

Autor: Nicolas O. Jørgensen, Rasmus Kjøbsted, Magnus R. Larsen, Jesper B. Birk, Nicoline R. Andersen, Bina Albuquerque, Peter Schjerling, Russell Miller, David Carling, Christian K. Pehmøller, Jørgen F.P. Wojtaszewski

Publikováno v: Molecular Metabolism, Vol 51, Iss , Pp 101259- (2021)

Objective: Skeletal muscle is an attractive target for blood glucose-lowering pharmacological interventions. Oral dosing of small molecule direct pan-activators of AMPK that bind to the allosteric drug and metabolite (ADaM) site, lowers blood glucose

Externí odkaz: https://doaj.org/article/0a8b7047e7614903a18b72c2dad7b2fd

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Akademický článek

Effect of exercise training on skeletal muscle protein expression in relation to insulin sensitivity: Per‐protocol analysis of a randomized controlled trial (GO‐ACTIWE)

Autor: Lea Bruhn, Rasmus Kjøbsted, Jonas Salling Quist, Anne Sofie Gram, Mads Rosenkilde, Kristine Færch, Jørgen F.P. Wojtaszewski, Bente Stallknecht, Martin Bæk Blond

Publikováno v: Physiological Reports, Vol 9, Iss 10, Pp n/a-n/a (2021)

Abstract Exercise training improves peripheral insulin sensitivity and leads to molecular adaptations in the skeletal muscle. We investigated changes in the expression of key muscle proteins in the glucose metabolic pathway following active commuting

Externí odkaz: https://doaj.org/article/250c0d0a092144cea4b1d19563103300

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Akademický článek

Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

Publikováno v: Molecular Metabolism, Vol 40, Iss , Pp 101028- (2020)

Objective: Evidence for AMP-activated protein kinase (AMPK)-mediated regulation of skeletal muscle metabolism during exercise is mainly based on transgenic mouse models with chronic (lifelong) disruption of AMPK function. Findings based on such model

Externí odkaz: https://doaj.org/article/7b639b94cb3449f3af4191459a29d7c6

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Akademický článek

ApoA-1 improves glucose tolerance by increasing glucose uptake into heart and skeletal muscle independently of AMPKα2

Autor: Andreas Mæchel Fritzen, Joan Domingo-Espín, Anne-Marie Lundsgaard, Maximilian Kleinert, Ida Israelsen, Christian S. Carl, Trine S. Nicolaisen, Rasmus Kjøbsted, Jacob F. Jeppesen, Jørgen F.P. Wojtaszewski, Jens O. Lagerstedt, Bente Kiens

Publikováno v: Molecular Metabolism, Vol 35, Iss , Pp - (2020)

Objective: Acute administration of the main protein component of high-density lipoprotein, apolipoprotein A-I (ApoA-1), improves glucose uptake in skeletal muscle. The molecular mechanisms mediating this are not known, but in muscle cell cultures, Ap

Externí odkaz: https://doaj.org/article/e7375ff2f5d843a68500a32a5a557945

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Akademický článek

Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

Publikováno v: Molecular Metabolism, Vol 11, Iss , Pp 160-177 (2018)

Objective: Given that cellular O-GlcNAcylation levels are thought to be real-time measures of cellular nutrient status and dysregulated O-GlcNAc signaling is associated with insulin resistance, we evaluated the role of O-GlcNAc transferase (OGT), the

Externí odkaz: https://doaj.org/article/261b3cbf836f43468337bc9950698585

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Akademický článek

Metformin does not compromise energy status in human skeletal muscle at rest or during acute exercise: A randomised, crossover trial

Autor: Jonas M. Kristensen, Christian Lillelund, Rasmus Kjøbsted, Jesper B. Birk, Nicoline R. Andersen, Lars Nybo, Karin Mellberg, Anudharan Balendran, Erik A. Richter, Jørgen F. P. Wojtaszewski

Publikováno v: Physiological Reports, Vol 7, Iss 23, Pp n/a-n/a (2019)

Abstract 5´AMP–activated protein kinase (AMPK) is a mediator of a healthy metabolic phenotype in skeletal muscle. Metformin may exacerbate the energy disturbances observed during exercise leading to enhanced AMPK activation, and these disturbances

Externí odkaz: https://doaj.org/article/be2109d25b604c91b5ee695c4d03de8e

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TBC1D4-S711 controls skeletal muscle insulin sensitization after exercise and contraction

Autor: Rasmus Kjøbsted, Jonas M. Kristensen, Nicolas O. Eskesen, Kohei Kido, Klara Fjorder, Ditte F. Damgaard, Jeppe K. Larsen, Nicoline R. Andersen, Jesper B. Birk, Anders Gudiksen, Jonas T. Treebak, Peter Schjerling, Henriette Pilegaard, Jørgen F. P. Wojtaszewski

Publikováno v: Kjøbsted, R, Kristensen, J M, Eskesen, N O, Kido, K, Fjorder, K, Damgaard, D F, Larsen, J K, Andersen, N R, Birk, J B, Gudiksen, A, Treebak, J T, Schjerling, P, Pilegaard, H & Wojtaszewski, J 2023, ' TBC1D4-S711 controls skeletal muscle insulin sensitization after exercise and contraction ', Diabetes, vol. 72, no. 7, pp. 857-871 . https://doi.org/10.2337/db22-0666

The ability of insulin to stimulate glucose uptake in skeletal muscle is important for whole-body glycemic control. Insulin-stimulated skeletal muscle glucose uptake is improved in the period after a single bout of exercise and accumulating evidence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89498ca981548113ae9d2d065d9355c
https://curis.ku.dk/ws/files/344709125/Kjobsted_et_al_Diabetes_2023_TBC1D4_S711A_manuscript_Submitted_version_.pdf

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