Metabolomic, DNA Methylomic, and Transcriptomic Profiling of Suberoylanilide Hydroxamic Acid Effects on LPS-Exposed Lung Epithelial Cells

Autor: Pochung Jordan Chou, Md Shahid Sarwar, Lujing Wang, Renyi Wu, Shanyi Li, Rasika R. Hudlikar, Yujue Wang, Xiaoyang Su, Ah-Ng Kong

Publikováno v: Cancer Prevention Research. 16:321-332

Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase (HDAC) inhibitor with anticancer effects via epigenetic and non-epigenetic mechanisms. The role of SAHA in metabolic rewiring and epigenomic reprogramming to inhibit pro-tumorigenic casc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66338b13c06168235b61f2a67796ff4e
https://doi.org/10.1158/1940-6207.capr-22-0384

Supplementary Fig. S2 from Metabolomic, DNA Methylomic, and Transcriptomic Profiling of Suberoylanilide Hydroxamic Acid Effects on LPS-Exposed Lung Epithelial Cells

Autor: Ah-Ng Kong, Xiaoyang Su, Yujue Wang, Rasika R. Hudlikar, Shanyi Li, Renyi Wu, Lujing Wang, Md Shahid Sarwar, Pochung Jordan Chou

Supplementary Fig. S2 shows the changes in metabolic profile after suberoylanilide hydroxamic acid (SAHA) treatment for 3 and 24 h.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947cbd8a68b5dc51de0a1a8e5b15b83d
https://doi.org/10.1158/1940-6207.22552137.v1

Tobacco carcinogen 4-[methyl(nitroso)amino]-1-(3-pyridinyl)-1-butanone (NNK) drives metabolic rewiring and epigenetic reprograming in A/J mice lung cancer model and prevention with diallyl sulphide (DAS)

Autor: Rasika R Hudlikar, Davit Sargsyan, David Cheng, Hsiao-Chen Dina Kuo, Renyi Wu, Xiaoyang Su, Ah-Ng Kong

Publikováno v: Carcinogenesis

Early detection of biomarkers in lung cancer is one of the best preventive strategies. Although many attempts have been made to understand the early events of lung carcinogenesis including cigarette smoking (CS) induced lung carcinogenesis, the integ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e33285947e17c1375e45dd8520a4db2
https://doi.org/10.1093/carcin/bgab119

Polymeric black tea polyphenols (PBPs) inhibit benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone-induced lung carcinogenesis potentially through down-regulation of p38 and Akt phosphorylation in A/J mice

Autor: Rasika R, Hudlikar, Varadha Balaji, Venkadakrishnan, Rajiv, Kumar, Rahul A, Thorat, Sadhana, Kannan, Arvind D, Ingle, Saral, Desai, Girish B, Maru, Manoj B, Mahimkar

Publikováno v: Molecular carcinogenesis. 56(2)

The aim of our study was to evaluate chemopreventive efficacy and possible mechanism of most abundant polyphenolic fraction in black tea, polymeric black tea polyphenols (PBPs), in experimental lung carcinogenesis model. Effect of 1.5% black tea deri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd3451aa932f95faaa5b393a681f0f5f
https://pubmed.ncbi.nlm.nih.gov/27377358

Redox signaling, mitochondrial metabolism, epigenetics and redox active phytochemicals.

Autor: Wu R; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA., Li S; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA., Hudlikar R; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA., Wang L; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA., Shannar A; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA., Peter R; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA., Chou PJ; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA., Kuo HD; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA., Liu Z; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA., Kong AN; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA. Electronic address: KongT@pharmacy.rutgers.edu.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2022 Feb 01; Vol. 179, pp. 328-336. Date of Electronic Publication: 2020 Dec 24.