Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Rashna D Balsara"'
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81405 (2013)
Three members of a family of small neurotoxic peptides from the venom of Conus parius, conantokins (Con) Pr1, Pr2, and Pr3, function as antagonists of N-methyl-D-aspartate receptors (NMDAR). We report structural characterizations of these synthetic p
Externí odkaz:
https://doaj.org/article/242d700ab10c4b8fa33b63aa9acd145b
Autor:
Francis J Castellino, Zhong Liang, Patrick K Davis, Rashna D Balsara, Harsha Musunuru, Deborah L Donahue, Denise L Smith, Mayra J Sandoval-Cooper, Victoria A Ploplis, Mark Walsh
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52878 (2012)
To delineate the critical features of platelets required for formation and stability of thrombi, thromboelastography and platelet aggregation measurements were employed on whole blood of normal patients and of those with Bernard-Soulier Syndrome (BSS
Externí odkaz:
https://doaj.org/article/39cdca1cd69d4c199bd8fa80aa341c6d
Autor:
Deborah L. Donahue, William T. Andrews, Rashna D. Balsara, Adam R. Holmes, Amanda B. Hummon, Francis J. Castellino
Publikováno v:
Analytical and Bioanalytical Chemistry. 412:6275-6285
The N-methyl-D-aspartate (NMDA) receptor is a crucial mediator of pathological glutamate-driven excitotoxicity and subsequent neuronal death in acute ischemic stroke. Although the roles of the NMDAR's composite GluN2A-C subunits have been investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d056740996152598052cfb7c56617748
https://doi.org/10.1007/s00216-020-02477-z
https://doi.org/10.1007/s00216-020-02477-z
Autor:
Phoebe Do Carmo Silva, Shaun W. Lee, Victoria A. Ploplis, Mayland Chang, Rashna D. Balsara, Alejandro J. Gonzalez, Jeshina Janardhanan, Francisco R. Fields, Jessica N Ross, Francis J. Castellino, Melanie Clifford, Ilona P. Foik, J. Mark Sutton, Charlotte K. Hind, Henry M. Vu, Veronica R. Kalwajtys, Tam T. T. Bui, A. James Mason, Albert Siryaporn, Giorgia Manzo
Publikováno v:
ACS pharmacology & translational science, vol 3, iss 3
ACS Pharmacol Transl Sci
ACS Pharmacol Transl Sci
[Image: see text] The ribosomally produced antimicrobial peptides of bacteria (bacteriocins) represent an unexplored source of membrane-active antibiotics. We designed a library of linear peptides from a circular bacteriocin and show that pore-format
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518178221ac268bd9e823af0dfc1caa9
https://escholarship.org/uc/item/1840t1c2
https://escholarship.org/uc/item/1840t1c2
Autor:
Shaun W. Lee, Teresa Brito-Robionson, Cunjia Qiu, Zhong Liang, Victoria A. Ploplis, Rashna D. Balsara, Jaroslav Zajicek, Yue Yuan, Francis J. Castellino
Publikováno v:
Journal of Structural Biology. 204:151-164
Group A Streptococcus pyogenes (GAS) is a causative agent of pharyngeal and dermal infections in humans. A major virulence determinant of GAS is its dimeric signature fibrillar M-protein (M-Prt), which is evolutionarily designed in modules, ranging f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f7b77d85b76090e898a563ade17735
https://doi.org/10.1016/j.jsb.2018.07.017
https://doi.org/10.1016/j.jsb.2018.07.017
Publikováno v:
Journal of Cardiology and Cardiovascular Sciences. 2:23-32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c24a321dd1eab14198735191998d8cde
https://doi.org/10.29245/2578-3025/2018/4.1133
https://doi.org/10.29245/2578-3025/2018/4.1133
Publikováno v:
Biochemical and Biophysical Research Communications. 495:136-144
The N-methyl-D-aspartate receptor (NMDAR) ion channel plays a pivotal role in the pathology of ischemic stroke. The functional receptor consists of two GluN1 subunits (a-h) and two GluN2 subunits (A/B/C/D), the expression of which are spatially and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9738af598e931ae59f8b4cacd476b3d
https://doi.org/10.1016/j.bbrc.2017.10.171
https://doi.org/10.1016/j.bbrc.2017.10.171
Autor:
Francisco R. Fields, Katelyn E. Carothers, Victoria A. Ploplis, Rashna D. Balsara, Francis J. Castellino, Shaun W. Lee
Publikováno v:
J Antibiot (Tokyo)
Bacteriocins hold unprecedented promise as a largely untapped source of antibiotic alternatives in the age of multidrug resistance. Here, we describe the first approach to systematically design variants of a novel AS-48 bacteriocin homologue, which w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e091ed9f1e002b3a59da00dbf98796d
https://europepmc.org/articles/PMC8887552/
https://europepmc.org/articles/PMC8887552/
Publikováno v:
Journal of Biological Chemistry. 290:18156-18172
Conantokins are ~20-amino acid peptides present in predatory marine snail venoms that function as allosteric antagonists of ion channels of the N-methyl-d-aspartate receptor (NMDAR). These peptides possess a high percentage of post-/co-translationall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482437aceccd43eef47fd12dcd020168
https://doi.org/10.1074/jbc.m115.650341
https://doi.org/10.1074/jbc.m115.650341
Publikováno v:
Journal of Neuroscience Research. 92:1767-1774
Retinal ganglion cells (RGCs), which are the sole output neurons of the retina, express N-methyl-D-aspartate receptors (NMDARs), rendering these cells susceptible to glutamate excitotoxicity, with implications for loss of normal RGC excitatory respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10058ec4974aae6a7ee31f02e30b959f
https://doi.org/10.1002/jnr.23447
https://doi.org/10.1002/jnr.23447