Výsledky vyhledávání - "Rashmi K. Shrestha"

Mutational analysis of a conserved positive charge in the c-ring of E. coli ATP synthase

Autor: Rashmi K. Shrestha, Michael W. Founds, Sam J. Shepard, Mallory M. Rothrock, Amy E. Defnet, P. Ryan Steed

F1Fo ATP synthase is a ubiquitous molecular motor that utilizes a rotary mechanism to synthesize adenosine triphosphate (ATP), the fundamental energy currency of life. The membrane-embedded Fo motor converts the electrochemical gradient of protons in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b22c62976a3c7da5338ad2a83928ad72
https://doi.org/10.1101/2022.07.28.501891

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Crystal structure of the Thr316Ala mutant of a yeast JAMM deubiquitinase: implication of active-site loop dynamics in catalysis

Autor: Chittaranjan Das, Rashmi K. Shrestha

Publikováno v: Acta Crystallogr F Struct Biol Commun

AMSH, an endosome-associated deubiquitinase (DUB) with a high specificity for Lys63-linked polyubiquitin chains, plays an important role in endosomal–lysosomal sorting and down-regulation of cell-surface receptors. AMSH belongs to the JAMM family o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b19fcf9b2cab10cf2fc3718b3b4cedc
https://europepmc.org/articles/PMC8186415/

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Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product

Autor: Rashmi K. Shrestha, Christopher W. Davies, Judith A. Ronau, Chittaranjan Das, Robert G. Guenette, Lake N. Paul, Eric R. Strieter

Publikováno v: Biochemistry

AMSH, a conserved zinc metallo deubiquitinase, controls downregulation and degradation of cell-surface receptors mediated by the endosomal sorting complexes required for transport (ESCRT) machinery. It displays high specificity toward the Lys63-linke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517f07966959c80d60c78d7a43251391
https://doi.org/10.1021/bi5003162

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Dynamics of an Active-Site Flap Contributes to Catalysis in a JAMM Family Metallo Deubiquitinase

Autor: Rashmi K. Shrestha, Amy N. Bueno, Michael J. Sheedlo, Chittaranjan Das, Aditya Babar, Judith A. Ronau, Lake N. Paul, Julian E. Fuchs

Publikováno v: Biochemistry. 54(39)

The endosome-associated deubiquitinase (DUB) AMSH is a member of the JAMM family of zinc-dependent metallo isopeptidases with high selectivity for Lys63-linked polyubiquitin chains, which play a key role in endosomal-lysosomal sorting of activated ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621dc0a281d2380cb7cd61594f1b69b6
https://pubmed.ncbi.nlm.nih.gov/26368668

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Intercalating dyes for enhanced contrast in second-harmonic generation imaging of protein crystals

Autor: Nicholas Roman Pogranichniy, Garth J. Simpson, Chittaranjan Das, Richard G. Closser, Justin A. Newman, Nicole M. Scarborough, Rashmi K. Shrestha

Publikováno v: Acta crystallographica. Section D, Biological crystallography. 71(Pt 7)

The second-harmonic generation (SHG) activity of protein crystals was found to be enhanced by up to ∼1000-fold by the intercalation of SHG phores within the crystal lattice. Unlike the intercalation of fluorophores, the SHG phores produced no signi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7abc73f67139debc7f57dd602b308cb8
https://pubmed.ncbi.nlm.nih.gov/26143918

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