Výsledky vyhledávání - "Rasha Z. Batran"

New antileishmanial quinoline linked isatin derivatives targeting DHFR-TS and PTR1: Design, synthesis, and molecular modeling studies

Autor: Ahmed Sabt, Wagdy M. Eldehna, Tamer M. Ibrahim, Adnan A. Bekhit, Rasha Z. Batran

Publikováno v: European Journal of Medicinal Chemistry. 246:114959

In a search for new drug candidates for one of the neglected tropical diseases, leishmaniasis, twenty quinoline-isatin hybrids were synthesized and tested for their in vitro antileishmanial activity against Leishmaniamajor strain. All the synthesized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98463ca9a93f8f980f099fa9d7b63120
https://doi.org/10.1016/j.ejmech.2022.114959

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Synthesis, homology modeling, molecular docking, dynamics, and antifungal screening of new 4-hydroxycoumarin derivatives as potential chitinase inhibitors

Autor: Abeer A. Abd El Aty, Rasha Z. Batran, Nehad A. Abdel Latif, Mohammed A. Khedr, Abeer N. Shehata

Publikováno v: Journal of Molecular Structure. 1180:260-271

The inhibition of chitinase activity is considered of great importance for the development of novel antifungal agents. Here we explore 4-hydroxycoumarins as a novel natural product-derived scaffold for inhibiting chitinases. A new series of 4-hydoxyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c02dfedad83d54219a66960d0048a17
https://doi.org/10.1016/j.molstruc.2018.11.099

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Synthesis, Molecular Docking and Dynamics Simulation Studies of New 7-oxycoumarin Derivatives as Potential Antioxidant Agents

Autor: Hanem M. Awad, Sara A F Al-Shehri, Nehad A. Abdel Latif, Salwa F. Mohamed, Mohamed I. Kobeasy, Mohammed A. Khedr, Rasha Z. Batran

Publikováno v: Mini-Reviews in Medicinal Chemistry. 18:1572-1587

Method Two new series of 4-styryl-7-oxycoumarin derivatives 3a-i and 4-styryl-7- oxycoumarinyl Mannich bases 6a-r were designed and synthesized. Ten compounds were evaluated for their antioxidant activity in vitro against DPPH and in vivo against lip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4221644d0a0571f8d8c7aa09fd5f47
https://doi.org/10.2174/1389557518666180423145246

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Coumarinyl pyranopyrimidines as new neuropeptide S receptor antagonists; design, synthesis, homology and molecular docking

Autor: Kuljeet S. Gugnani, Dina H. Dawood, Alejandro N. Rondon-Ortiz, Timothy J. Maher, Rasha Z. Batran, Samia A. Elseginy

Publikováno v: Bioorganic Chemistry. 75:274-290

In this work, we described the design, synthesis and characterization of a new class of NPSR antagonists bearing the tetracyclic coumarinyl pyranopyrimidine scaffold incorporated with different acyclic and/or heterocyclic moieties. These compounds ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339f17a7df874037ac932c90292fad93
https://doi.org/10.1016/j.bioorg.2017.09.017

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New quinolone derivatives as neuropeptide S receptor antagonists: Design, synthesis, homology modeling, dynamic simulations and modulation of Gq/Gs signaling pathways

Autor: Timothy J. Maher, Kuljeet S. Gugnani, Rasha Z. Batran, Mohammed A. Khedr

Publikováno v: Bioorganic Chemistry. 111:104817

In a search for new neuropeptide S receptor antagonists, we have described a new series of quinolone-pyranopyrimidine hybrid derivatives aiming to modify the inhibitory characters towards NPSR to develop new therapeutic strategies against anxiety, ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e09692b480e4ae88a940a2f315fd52
https://doi.org/10.1016/j.bioorg.2021.104817

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3-Substituted-4-hydroxycoumarin as a new scaffold with potent CDK inhibition and promising anticancer effect: Synthesis, molecular modeling and QSAR studies

Autor: Nehad A. Abdel Latif, Mohamed M. Abdalla, Mohammed A. Khedr, Rasha Z. Batran

Publikováno v: Bioorganic Chemistry. 67:116-129

A new series of 3-substituted-4-hydroxycoumarin derivatives was designed, synthesized, and evaluated for CDK inhibiting and anticancer activities. All the synthesized target compounds showed remarkably high affinity and selectivity towards CDK1B, com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905de49eee89f7374d427c793ee21e4b
https://doi.org/10.1016/j.bioorg.2016.06.005

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New 4-phenylcoumarin derivatives as potent 3C protease inhibitors: Design, synthesis, anti-HAV effect and molecular modeling

Autor: Asmaa F. Kassem, Samia A. Elseginy, Mohamed N. F. Shaheen, Eman M. H. Abbas, Elmahdy M. Elmahdy, Rasha Z. Batran

Publikováno v: European journal of medicinal chemistry. 168

A new series of 4-phenylcoumarin derivatives was synthesized starting from (2-oxo-4-phenyl-2H-chromen-7-yloxy) acetic acid hydrazide 3. Evaluation of the target compounds for their antiviral activity against hepatitis A virus revealed that the ethylt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52979856d0007d3795bf7b8a02df4fc2
https://pubmed.ncbi.nlm.nih.gov/30844608

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Synthesis, anticancer effect and molecular modeling of new thiazolylpyrazolyl coumarin derivatives targeting VEGFR-2 kinase and inducing cell cycle arrest and apoptosis

Autor: Abeer E. Mahmoud, Rasha Z. Batran, Samia A. Elseginy, Tahia K. Mohamed, Mamdouh M. Ali

Publikováno v: Bioorganic chemistry. 85

New thiazolylpyrazolyl coumarin derivatives were synthesized and tested for their anticancer potential in vitro against five different human cell lines, including breast MCF-7, lung A549, prostate PC3, liver HepG2 and normal melanocyte HFB4. Breast c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce3ceb20519145aaf2f6f9ffc1ecf3b
https://pubmed.ncbi.nlm.nih.gov/30641320

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