Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rasha Y. Elbayaa"'
Publikováno v:
Letters in Drug Design & Discovery. 16:200-212
Background: In attempts to discover new antiangiogenic entities, a novel series of thioethers derived from 6-thioxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidine-4(5H)ones was considered and designed. Methods: Virtual screening was carried out through doc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac70ae45625f7a202f3e3addb873f508
https://doi.org/10.2174/1570180815666180518112321
https://doi.org/10.2174/1570180815666180518112321
Autor:
Abeer E. Abdel Wahab, Ibrahim A. Abdelwahab, Rasha Y. Elbayaa, Soad A.M. El-Hawash, Maryam A.Z. El-Attar, Omaima G. Shaaban, Nargues S. Habib
Publikováno v:
Bioorganic Chemistry. 76:437-448
Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. From this perspective, new quinoxaline derivatives bearing various bioactive heterocyclic moieties (thiadiazoles, oxadiazoles, pyrazoles and thiazoles) w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fb8a02ad7b5c8e8eac122e3868821a
https://doi.org/10.1016/j.bioorg.2017.12.017
https://doi.org/10.1016/j.bioorg.2017.12.017
Autor:
Soad A.M. El-Hawash, Maryam A.Z. El-Attar, Abeer E. Abdel Wahab, Ibrahim A. Abdelwahab, Nargues S. Habib, Omaima G. Shaaban, Rasha Y. Elbayaa
Publikováno v:
Future medicinal chemistry. 10(18)
Aim: The development of a new class of antimicrobial agents is the optimal lifeline to scrap the escalating jeopardy of drug resistance. Experimental: This study aims to design and synthesize a series of pyrazolo-1,2,4-triazolo[4,3-a]quinoxalines, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa97c880615d6e65be164d92c1d2148
https://pubmed.ncbi.nlm.nih.gov/30088415
https://pubmed.ncbi.nlm.nih.gov/30088415
Publikováno v:
Medicinal Chemistry.
The incentive of the present work has been primarily directed towards the design and synthesis of some novel pyrido[1,2-a]benzimidazoles with specific functionalities believed to have alkylation ability. This combination of pharmacological agents may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c453a9f862fb5eee71b77c0ed1f7241
https://doi.org/10.4172/2161-0444.1000498
https://doi.org/10.4172/2161-0444.1000498
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 30:786-795
In this study, novel thiosemicarbazides and 1,3,4-oxadiazoles were synthesized and evaluated for their anticancer effects on human MCF-7 breast cancer cell lines. Among the synthesized derivatives studied, compound 2-(3-(4-chlorophenyl)-3-hydroxybuta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f545900ba6eef2e432a49414d98dc54
https://doi.org/10.3109/14756366.2014.971781
https://doi.org/10.3109/14756366.2014.971781
Autor:
Rasha Y. Elbayaa
Publikováno v:
Medicinal Chemistry. 10:66-73
As a part of a research project pertaining to the synthesis of novel candidates as nonsedating, nonclassic H₁ histaminergic (H₁) blockers with low toxicity profiles, some new 5-substituted aminomethylenepyrimidine-2,4,6-triones were designed base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7adde2181bd158463971f31eb11e88ca
https://doi.org/10.2174/15734064113099990032
https://doi.org/10.2174/15734064113099990032
Publikováno v:
Bioorganic chemistry. 72
Small molecules that can target human cancers have been highly sought to increase the anticancer efficacy, the present work describes the design and synthesis of novel series of five quinuclidinone derivatives (2a-2e). Their anticancer activities wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684199270083c2db164b436bc138a248
https://pubmed.ncbi.nlm.nih.gov/28366825
https://pubmed.ncbi.nlm.nih.gov/28366825
Publikováno v:
Medicinal Chemistry. 8:151-162
Most of cancer chemotherapeutics and chemopreventives exert their effects by triggering apoptotic cell death. In this study, novel benzimidazole and benzothiazole derivatives have been synthesized to investigate their effects on HepG2 liver cancer ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70da9789d0706a8acdcf8998d86cd3a
https://doi.org/10.2174/157340612800493719
https://doi.org/10.2174/157340612800493719
Autor:
M. I. Jaeda, Mona M. El-Semary, Rasha Y. Elbayaa, Manal N. S. Saudi, Maha M. Eissa, Nahed M. Baddour, Eglal I. Amer
Publikováno v:
Medicinal Chemistry Research. 21:257-267
Leishmaniases are a group of diseases caused by the protozoan parasites of the genus Leishmania. Despite the tremendous progress made in the understanding of the biochemistry and molecular biology of the parasite, the first choice treatment for leish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::830ad99036d3d3ffc3330af4e5e42a89
https://doi.org/10.1007/s00044-010-9532-x
https://doi.org/10.1007/s00044-010-9532-x
Autor:
Mervat Z. El-Azzouni, Shereen F. Mossallam, Nahed M. Baddour, Rasha Y. Elbayaa, Maha M. Eissa, Mona H. Badr, Manal N. S. Saudi, Amal M. Youssef
Publikováno v:
Letters in Drug Design & Discovery. 6:268-277
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b7250f5a9d13a58c202c0e44e859496
https://doi.org/10.2174/157018009788452546
https://doi.org/10.2174/157018009788452546