Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rasha Y. Elbayaa"'
Publikováno v:
Letters in Drug Design & Discovery. 16:200-212
Background: In attempts to discover new antiangiogenic entities, a novel series of thioethers derived from 6-thioxo-6,7-dihydro-1H-pyrazolo[3,4-d]pyrimidine-4(5H)ones was considered and designed. Methods: Virtual screening was carried out through doc
Autor:
Abeer E. Abdel Wahab, Ibrahim A. Abdelwahab, Rasha Y. Elbayaa, Soad A.M. El-Hawash, Maryam A.Z. El-Attar, Omaima G. Shaaban, Nargues S. Habib
Publikováno v:
Bioorganic Chemistry. 76:437-448
Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. From this perspective, new quinoxaline derivatives bearing various bioactive heterocyclic moieties (thiadiazoles, oxadiazoles, pyrazoles and thiazoles) w
Autor:
Soad A.M. El-Hawash, Maryam A.Z. El-Attar, Abeer E. Abdel Wahab, Ibrahim A. Abdelwahab, Nargues S. Habib, Omaima G. Shaaban, Rasha Y. Elbayaa
Publikováno v:
Future medicinal chemistry. 10(18)
Aim: The development of a new class of antimicrobial agents is the optimal lifeline to scrap the escalating jeopardy of drug resistance. Experimental: This study aims to design and synthesize a series of pyrazolo-1,2,4-triazolo[4,3-a]quinoxalines, to
Publikováno v:
Medicinal Chemistry.
The incentive of the present work has been primarily directed towards the design and synthesis of some novel pyrido[1,2-a]benzimidazoles with specific functionalities believed to have alkylation ability. This combination of pharmacological agents may
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 30:786-795
In this study, novel thiosemicarbazides and 1,3,4-oxadiazoles were synthesized and evaluated for their anticancer effects on human MCF-7 breast cancer cell lines. Among the synthesized derivatives studied, compound 2-(3-(4-chlorophenyl)-3-hydroxybuta
Publikováno v:
Bioorganic chemistry. 72
Small molecules that can target human cancers have been highly sought to increase the anticancer efficacy, the present work describes the design and synthesis of novel series of five quinuclidinone derivatives (2a-2e). Their anticancer activities wer
Autor:
Rasha Y. Elbayaa
Publikováno v:
Medicinal Chemistry. 10:66-73
As a part of a research project pertaining to the synthesis of novel candidates as nonsedating, nonclassic H₁ histaminergic (H₁) blockers with low toxicity profiles, some new 5-substituted aminomethylenepyrimidine-2,4,6-triones were designed base
Publikováno v:
Medicinal Chemistry. 8:151-162
Most of cancer chemotherapeutics and chemopreventives exert their effects by triggering apoptotic cell death. In this study, novel benzimidazole and benzothiazole derivatives have been synthesized to investigate their effects on HepG2 liver cancer ce
Autor:
Ahmed Malki, Rasha Y. Elbayaa, Doaa A. E. Issa, Hassan A. Aziz, Hayam M. A. Ashour, Xiaozhuo Chen
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 31(6)
Novel 1,5-diphenyl-6-substituted-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones were synthesized and characterized. All compounds were screened for their anti-proliferative activities in five different cancer cell lines. The results showed that compounds 7a
Autor:
Hanan M. Ragab, Wissam H. Faour, Costatantine F. Daher, Rasha Y. Elbayaa, Mohamed Mroueh, Hayam M. A. Ashour, Ahmed I. Elmallah, Asser I. Ghoneim
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 31(6)
Four series of new bipyrazoles comprising the N-phenylpyrazole scaffold linked to polysubstituted pyrazoles or to antipyrine moiety through different amide linkages were synthesized. The synthesized compounds were evaluated for their anti-inflammator