The mechanistic basis of pH-dependent 5-flucytosine resistance in Aspergillus fumigatus

Autor: Gsaller, Fabio, Furukawa, Takanori, Carr, Paul D., Rash, Bharatkumar, Jöchl, Christoph, Bertuzzi, Margherita, Bignell, Elaine, Bromley, Michael

Publikováno v: Gsaller, F, Furukawa, T, Carr, P D, Rash, B, Jöchl, C, Bertuzzi, M, Bignell, E & Bromley, M 2018, ' The mechanistic basis of pH-dependent 5-flucytosine resistance in Aspergillus fumigatus ', Antimicrobial Agents and Chemotherapy, vol. 62, no. 6, pp. e02593-17 . https://doi.org/10.1128/AAC.02593-17, https://doi.org/10.1128/aac.02593-17

The antifungal drug 5-flucytosine (5FC), a derivative of the nucleobase cytosine, is licensed for the treatment of fungal diseases; however, it is rarely used as a monotherapeutic to treat Aspergillus infection. Despite being potent against other fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::32bdc5b676b967635ecad0e42f3eed15
https://doi.org/10.1128/AAC.02593-17

A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatusand Is Critical for Pathogenicity

Autor: Johns, Anna, Scharf, Daniel H., Gsaller, Fabio, Schmidt, Hella, Heinekamp, Thorsten, Straßburger, Maria, Oliver, Jason D., Birch, Mike, Beckmann, Nicola, Dobb, Katharine S., Gilsenan, Jane, Rash, Bharatkumar, Bignell, Elaine, Brakhage, Axel A., Bromley, Michael J.

Publikováno v: mBio; July 2017, Vol. 8 Issue: 4