Growth control of the eukaryote cell: a systems biology study in yeast

Autor: Castrillo Juan I, Zeef Leo A, Hoyle David C, Zhang Nianshu, Hayes Andrew, Gardner David CJ, Cornell Michael J, Petty June, Hakes Luke, Wardleworth Leanne, Rash Bharat, Brown Marie, Dunn Warwick B, Broadhurst David, O'Donoghue Kerry, Hester Svenja S, Dunkley Tom PJ, Hart Sarah R, Swainston Neil, Li Peter, Gaskell Simon J, Paton Norman W, Lilley Kathryn S, Kell Douglas B, Oliver Stephen G

Publikováno v: Journal of Biology, Vol 6, Iss 2, p 4 (2007)

Abstract Background Cell growth underlies many key cellular and developmental processes, yet a limited number of studies have been carried out on cell-growth regulation. Comprehensive studies at the transcriptional, proteomic and metabolic levels und

Externí odkaz: https://doaj.org/article/f326c94ee88b4bbc87833253044b8a32

Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex

Autor: Gsaller, Fabio, Hortschansky, Peter, Furukawa, Takanori, Carr, Paul D., Rash, Bharat, Capilla, Javier, Müller, Christoph, Bracher, Franz, Bowyer, Paul, Haas, Hubertus, Brakhage, Axel A., Bromley, Michael J.

Publikováno v: PLoS Pathogens, Vol 12, Iss 7, p e1005775 (2016)
Plos Pathogens
PLoS Pathogens
Gsaller, F, Hortschansky, P, Furukawa, T, Carr, P D, Rash, B, Capilla, J, Müller, C, Bracher, F, Bowyer, P, Haas, H, Brakhage, A A & Bromley, M J 2016, ' Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex ', PL o S Pathogens, vol. 12, no. 7, e1005775 . https://doi.org/10.1371/journal.ppat.1005775

Azole drugs selectively target fungal sterol biosynthesis and are critical to our antifungal therapeutic arsenal. However, resistance to this class of drugs, particularly in the major human mould pathogen Aspergillus fumigatus, is emerging and reachi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5df9ca3c55df7081df89a7a7b3203d1a
http://europepmc.org/articles/PMC4954732?pdf=render

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