Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rasem Mustafa"'
Autor:
Aynur Sönmez, Rasem Mustafa, Salome T. Ryll, Francesca Tuorto, Ludivine Wacheul, Donatella Ponti, Christian Litke, Tanja Hering, Kerstin Kojer, Jenniver Koch, Claudia Pitzer, Joachim Kirsch, Andreas Neueder, Grzegorz Kreiner, Denis L. J. Lafontaine, Michael Orth, Birgit Liss, Rosanna Parlato
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Abstract Transcriptional and cellular-stress surveillance deficits are hallmarks of Huntington’s disease (HD), a fatal autosomal-dominant neurodegenerative disorder caused by a pathological expansion of CAG repeats in the Huntingtin (HTT) gene. The
Externí odkaz:
https://doaj.org/article/ef5389a9059145348fc5353ee8922ca1
Autor:
Rasem Mustafa, Grzegorz Kreiner, Katarzyna Kamińska, Amelia-Elise J. Wood, Joachim Kirsch, Kerry L. Tucker, Rosanna Parlato
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Multiple pathomechanisms triggered by mutant Huntingtin (mHTT) underlie progressive degeneration of dopaminoceptive striatal neurons in Huntington’s disease (HD). The primary cilium is a membrane compartment that functions as a hub for various path
Externí odkaz:
https://doaj.org/article/3395b7c3450444e69c5d4d9c577c1e55
Autor:
Rasem Mustafa, Chahinaz Rawas, Nadja Mannal, Grzegorz Kreiner, Björn Spittau, Katarzyna Kamińska, Rüstem Yilmaz, Christina Pötschke, Joachim Kirsch, Birgit Liss, Kerry L. Tucker, Rosanna Parlato
Publikováno v:
Antioxidants, Vol 10, Iss 8, p 1284 (2021)
Primary cilia (PC) are microtubule-based protrusions of the cell membrane transducing molecular signals during brain development. Here, we report that PC are required for maintenance of Substantia nigra (SN) dopaminergic (DA) neurons highly vulnerabl
Externí odkaz:
https://doaj.org/article/d98629c1c86f4fd5804825c4701b9a09
Autor:
Valentin Evsyukov, Andrii Domanskyi, Holger Bierhoff, Suzana Gispert, Rasem Mustafa, Falk Schlaudraff, Birgit Liss, Rosanna Parlato
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 5, Pp 633-643 (2017)
Genetic mutations underlying neurodegenerative disorders impair ribosomal DNA (rDNA) transcription suggesting that nucleolar dysfunction could be a novel pathomechanism in polyglutamine diseases and in certain forms of amyotrophic lateral sclerosis/f
Externí odkaz:
https://doaj.org/article/54dc73aef5084b65a8c262fd83a1a2f4
Autor:
Soenmez A, Francesca Tuorto, Andreas Neueder, Ludivine Wacheul, Grzegorz Kreiner, Tanja Hering, Rasem Mustafa, Ryll St, Birgit Liss, Michael Orth, Ponti D, Christian Litke, Rosanna Parlato, Joachim Kirsch, Koch J, Claudia Pitzer, Kerstin Kojer, Denis L. J. Lafontaine
Transcriptional and cellular stress surveillance deficits are hallmarks of Huntington’s disease (HD), a fatal autosomal dominant neurodegenerative disorder, caused by a pathological expansion of CAG repeats in the Huntingtin (HTT) gene. The nucleol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7267a27c2fdbe60d311554532f71f85
https://doi.org/10.1101/2021.07.09.451766
https://doi.org/10.1101/2021.07.09.451766
Autor:
Grzegorz Kreiner, Nadja Mannal, Rasem Mustafa, Björn Spittau, Joachim Kirsch, Kerry L. Tucker, Rosanna Parlato, Rüstem Yilmaz, Christina Pötschke, Chahinaz Rawas, Katarzyna Kamińska, Birgit Liss
Publikováno v:
Antioxidants, Vol 10, Iss 1284, p 1284 (2021)
Antioxidants
Volume 10
Issue 8
Antioxidants
Volume 10
Issue 8
Primary cilia (PC) are microtubule-based protrusions of the cell membrane transducing molecular signals during brain development. Here, we report that PC are required for maintenance of Substantia nigra (SN) dopaminergic (DA) neurons highly vulnerabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5863d36a074bf945b46f46648ac28c89
https://pub.uni-bielefeld.de/record/2957243
https://pub.uni-bielefeld.de/record/2957243
Autor:
Aynur Sönmez, Tanja Hering, Salome Tabea Spieth, Kerstin Kojer, Christian Litke, Birgit Liss, Jenniver Koch, Rosanna Parlato, Michael Orth, Rasem Mustafa
Publikováno v:
Pathogenic mechanisms.
Background Transcriptional and metabolic dysregulation are known to occur in Huntington’s disease (HD). Mutant huntingtin (mHTT) protein affects several cellular functions hindering the identification of the primary pathogenic event. Impaired trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5e1297b95b321ba01f009910ca0a4ac
https://doi.org/10.1136/jnnp-2018-ehdn.9
https://doi.org/10.1136/jnnp-2018-ehdn.9
Autor:
Birgit Liss, Andrii Domanskyi, Rasem Mustafa, Falk Schlaudraff, Valentin Evsyukov, Holger Bierhoff, Rosanna Parlato, Suzana Gispert
Publikováno v:
Disease models & mechanisms, 10(5):633-643
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 10, Iss 5, Pp 633-643 (2017)
Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 10, Iss 5, Pp 633-643 (2017)
Genetic mutations underlying neurodegenerative disorders impair ribosomal DNA (rDNA) transcription suggesting that nucleolar dysfunction could be a novel pathomechanism in polyglutamine diseases and in certain forms of amyotrophic lateral sclerosis/f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72525e4129953ce897b8c4e9a73e5f3d
https://repository.publisso.de/resource/frl:6408376
https://repository.publisso.de/resource/frl:6408376
Autor:
Aynur Soenmez, Holger Bierhoff, Rasem Mustafa, Jose E. Naranjo, Rosanna Parlato, Salome Tabea Spieth, Grzegorz Kreiner, Francesca Tuorto, Birgit Liss, Christian Litke
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 87:A16.1-A16
Background The expansion of CAG repeats in the mutant huntingtin (mHtt) protein impairs, among other fundamental cellular functions, the transcription of rRNA genes causing inhibition of rRNA synthesis and consequent disruption of nucleolar integrity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::481865e8f86441234eab5e82c97b5c91
https://doi.org/10.1136/jnnp-2016-314597.51
https://doi.org/10.1136/jnnp-2016-314597.51