Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system

Autor: Jie Liu, Zehua Zuo, Rasem Fattah, Toren Finkel, Stephen H. Leppla, Shihui Liu

Publikováno v: mBio, Vol 15, Iss 12 (2024)

ABSTRACT Bacillus anthracis causes anthrax through a combination of bacterial infection and toxemia. As a major virulence factor of B. anthracis, anthrax lethal toxin (LT) is a zinc-dependent metalloproteinase, exerting its cytotoxicity through prote

Externí odkaz: https://doaj.org/article/705cd8d2d47949748c4c4684ef5f2571

The Bacillus cereus Hbl and Nhe tripartite enterotoxin components assemble sequentially on the surface of target cells and are not interchangeable.

Autor: Inka Sastalla, Rasem Fattah, Nicole Coppage, Poulomi Nandy, Devorah Crown, Andrei P Pomerantsev, Stephen H Leppla

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e76955 (2013)

Bacillus cereus is a spore-forming, Gram-positive bacterium commonly associated with outbreaks of food poisoning. It is also known as an opportunistic pathogen causing clinical infections such as bacteremia, meningitis, pneumonia, and gas gangrene-li

Externí odkaz: https://doaj.org/article/37e4c17b5ed24b6581afd786879cc243

Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages.

Autor: Kristina A Hellmich, Jonathan L Levinsohn, Rasem Fattah, Zachary L Newman, Nolan Maier, Inka Sastalla, Shihui Liu, Stephen H Leppla, Mahtab Moayeri

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49741 (2012)

Anthrax lethal factor (LF) is the protease component of anthrax lethal toxin (LT). LT induces pyroptosis in macrophages of certain inbred mouse and rat strains, while macrophages from other inbred strains are resistant to the toxin. In rats, the sens

Externí odkaz: https://doaj.org/article/7769dd7468d341399e76a5d594b64fd8

Bacillus anthracis Virulence Regulator AtxA Binds Specifically to the

Autor: Rita M, McCall, Mary E, Sievers, Rasem, Fattah, Rodolfo, Ghirlando, Andrei P, Pomerantsev, Stephen H, Leppla

Publikováno v: J Bacteriol

Anthrax toxin activator (AtxA) is the master virulence gene regulator of Bacillus anthracis. It regulates genes on the chromosome as well as the pXO1 and pXO2 plasmids. It is not clear how AtxA regulates these genes, and direct binding of AtxA to its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a58cd898f437e4b0b148b343a8bc7c02
https://pubmed.ncbi.nlm.nih.gov/31570528

Interactions of High-Affinity Cationic Blockers with the Translocation Pores of B. anthracis, C. botulinum, and C. perfringens Binary Toxins

Autor: Vladimir A. Karginov, Holger Barth, Sergey M. Bezrukov, Xian Liu, Stephen H. Leppla, Alexander N. Wein, Michel R. Popoff, Ekaterina M. Nestorovich

Publikováno v: Biophysical Journal
Biophysical Journal, Biophysical Society, 2012, 103 (6), pp.1208-1217. ⟨10.1016/j.bpj.2012.07.050⟩
Biophysical Journal, 2012, 103 (6), pp.1208-1217. ⟨10.1016/j.bpj.2012.07.050⟩

International audience; Cationic β-cyclodextrin derivatives were recently introduced as highly effective, potentially universal blockers of three binary bacterial toxins: anthrax toxin of Bacillus anthracis, C2 toxin of Clostridium botulinum, and io

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d062d9d7dac38205af69a27af8ea4ee2