Synthetic and natural protease inhibitors provide insights into parasite development, virulence and pathogenesis

Autor: Rascón Aa, McKerrow Jh

Publikováno v: Current medicinal chemistry. 20(25)

Protease function is essential to many biological systems and processes. In parasites, proteases are essential for host tissue degradation, immune evasion, and nutrition acquisition. Helminths (worms) depend on several classes of proteases for develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211e5f6758aca530b323b35686176c92
https://pubmed.ncbi.nlm.nih.gov/23514418

Characterization of essential eggshell proteins from Aedes aegypti mosquitoes.

Autor: Isoe J; Department of Entomology, The University of Arizona, Tucson, AZ, 85721, USA. jisoe@ag.arizona.edu., Simington CJ; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ, 85721, USA.; Present address: Department of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA94720, USA., Oscherwitz ME; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ, 85721, USA.; Present address: Heersink School of Medicine, University of Alabama, Birmingham, AL, 35233, USA., Peterson AJ; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ, 85721, USA., Rascón AA Jr; Department of Chemistry, San José State University, San José, CA, 95192, USA.; Present address: School of Molecular Sciences, Arizona State University, Tempe, AZ, 85281, USA., Massani BB; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ, 85721, USA., Miesfeld RL; Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ, 85721, USA., Riehle MA; Department of Entomology, The University of Arizona, Tucson, AZ, 85721, USA. mriehle@ag.arizona.edu.

Publikováno v: BMC biology [BMC Biol] 2023 Oct 13; Vol. 21 (1), pp. 214. Date of Electronic Publication: 2023 Oct 13.

Soluble expression of recombinant midgut zymogen (native propeptide) proteases from the Aedes aegypti Mosquito Utilizing E. coli as a host.

Autor: Nguyen JT; Department of Chemistry, Duncan Hall 612, One Washington Square, San José State University, San José, CA, 95192, USA., Fong J; Department of Chemistry, Duncan Hall 612, One Washington Square, San José State University, San José, CA, 95192, USA., Fong D; Department of Chemistry, Duncan Hall 612, One Washington Square, San José State University, San José, CA, 95192, USA., Fong T; Department of Chemistry, Duncan Hall 612, One Washington Square, San José State University, San José, CA, 95192, USA., Lucero RM; Department of Chemistry, Duncan Hall 612, One Washington Square, San José State University, San José, CA, 95192, USA., Gallimore JM; Department of Chemistry, Duncan Hall 612, One Washington Square, San José State University, San José, CA, 95192, USA., Burata OE; Department of Chemistry, Duncan Hall 612, One Washington Square, San José State University, San José, CA, 95192, USA., Parungao K; Department of Chemistry, Duncan Hall 612, One Washington Square, San José State University, San José, CA, 95192, USA., Rascón AA Jr; Department of Chemistry, Duncan Hall 612, One Washington Square, San José State University, San José, CA, 95192, USA. alberto.rascon@sjsu.edu.

Publikováno v: BMC biochemistry [BMC Biochem] 2018 Dec 18; Vol. 19 (1), pp. 12. Date of Electronic Publication: 2018 Dec 18.

Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis.

Autor: Bulman CA; Center for Discovery and Innovation in Parasitic Diseases, University of California San Francisco, San Francisco, California, United States of America., Bidlow CM; Center for Discovery and Innovation in Parasitic Diseases, University of California San Francisco, San Francisco, California, United States of America., Lustigman S; Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America., Cho-Ngwa F; Department of Biochemistry and Molecular Biology, University of Buea, Buea, SW Region, Cameroon., Williams D; Department of Immunology and Microbiology, Rush University Medical Center, Chicago, Illinois, United States of America., Rascón AA Jr; Center for Discovery and Innovation in Parasitic Diseases, University of California San Francisco, San Francisco, California, United States of America; Department of Chemistry, San Jose State University, San Jose, California, United States of America., Tricoche N; Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America., Samje M; Department of Biochemistry and Molecular Biology, University of Buea, Buea, SW Region, Cameroon., Bell A; Lindsley F. Kimball Research Institute, New York Blood Center, New York, New York, United States of America., Suzuki B; Center for Discovery and Innovation in Parasitic Diseases, University of California San Francisco, San Francisco, California, United States of America., Lim KC; Center for Discovery and Innovation in Parasitic Diseases, University of California San Francisco, San Francisco, California, United States of America., Supakorndej N; FilariaTech, Athens, Georgia, United States of America., Supakorndej P; Department of Infectious Diseases, University of Georgia, Athens, Georgia, United States of America., Wolfe AR; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America., Knudsen GM; UCSF Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America., Chen S; Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America., Wilson C; Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America., Ang KH; Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America., Arkin M; Small Molecule Discovery Center, University of California San Francisco, San Francisco, California, United States of America., Gut J; Center for Discovery and Innovation in Parasitic Diseases, University of California San Francisco, San Francisco, California, United States of America., Franklin C; Center for Discovery and Innovation in Parasitic Diseases, University of California San Francisco, San Francisco, California, United States of America., Marcellino C; Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America., McKerrow JH; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America., Debnath A; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, California, United States of America., Sakanari JA; Center for Discovery and Innovation in Parasitic Diseases, University of California San Francisco, San Francisco, California, United States of America.

Publikováno v: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2015 Feb 20; Vol. 9 (2), pp. e0003534. Date of Electronic Publication: 2015 Feb 20 (Print Publication: 2015).

In vitro activation and enzyme kinetic analysis of recombinant midgut serine proteases from the Dengue vector mosquito Aedes aegypti.

Autor: Rascón AA Jr; Department of Chemistry & Biochemistry, and Center for Insect Science West Room 518, 1041 E, Lowell St., University of Arizona, Tucson, AZ, 85721, USA., Gearin J, Isoe J, Miesfeld RL

Publikováno v: BMC biochemistry [BMC Biochem] 2011 Aug 09; Vol. 12, pp. 43. Date of Electronic Publication: 2011 Aug 09.